Traitor-virus-guided discovery of antiviral factors

Project Information

Traitor-Viruses

Grant agreement ID: 101054456

DOI

10.3030/101054456

EC signature date 29 June 2022

Start date 1 July 2022

End date 30 June 2027

Funded under

• European Research Council (ERC)

Total cost

€ 2 339 875,00

EU contribution

€ 2 339 875,00

Coordinated by

UNIVERSITAET ULM
Germany

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Data Management Plan (1)

Data Management Plan

Drafting of Data Management Plan

Publications

Peer reviewed articles (7)

RPLP1 restricts HIV-1 transcription by disrupting C/EBPβ binding to the LTR.

Author(s): Weijing Yang, Hong Wang, Zhaolong Li, Lihua Zhang, Jianhui Liu, Frank Kirchhoff, Chen Huan and Wenyan Zhang
Published in: Nat Commun, 2024, ISSN 2041-1723
Publisher: Nature
DOI: 10.1038/s41467-024-49622-1

Replication competent HIV-guided CRISPR screen identifies antiviral factors including targets of the accessory protein Nef.

Author(s): Caterina Prelli Bozzo, Alexandre Laliberté, Aurora De Luna, Chiara Pastorio, Kerstin Regensburger, Stefan Krebs, Alexander Graf , Helmut Blum, Meta Volcic, Konstantin M. J. Sparrer & Frank Kirchhoff
Published in: Nat Commun, 2024, ISSN 2041-1723
Publisher: Naute
DOI: 10.1038/s41467-024-48228-x

Phosphatidylserine-exposing extracellular vesicles in body fluids are an innate defence against apoptotic mimicry viral pathogens

Author(s): Rüdiger Groß, Hanna Reßin,Pascal von Maltitz,Dan Albers,Laura Schneider,Hanna Bley,Markus Hoffmann,Mirko Cortese,Dhanu Gupta,Miriam Deniz,Jae-Yeon Choi,Jenny Jansen,Christian Preußer,Kai Seehafer,Stefan Pöhlmann,Dennis R. Voelker,Christine Goffinet et al.
Published in: Nat Microbiol, 2024, ISSN 2058-5276
Publisher: Nature
DOI: 10.1038/s41564-024-01637-6

Impact of HIV-1 Vpu-mediated downregulation of CD48 on NK-cell-mediated antibody-dependent cellular cytotoxicity

Author(s): Lorie Marchitto,Mehdi Benlarbi,Jérémie Prévost,Annemarie Laumaea,Jade Descôteaux-Dinelle,Halima Medjahed,Catherine Bourassa,Gabrielle Gendron-Lepage,Frank Kirchhoff,Daniel Sauter,Beatrice H. Hahn,Andrés Finzi and Jonathan Richard
Published in: mBio, 2023, ISSN 2150-7511
Publisher: ASM
DOI: 10.1128/mbio.00789-23

Impact of HIV-1 Vpu-mediated downregulation of CD48 on NK-cell-mediated antibody-dependent cellular cytotoxicity

Author(s): Marchitto, Lorie; Benlarbi, Mehdi; Prévost, Jérémie; Laumaea, Annemarie; Descôteaux-Dinelle, Jade; Medjahed, Halima; Bourassa, Catherine; Gendron-Lepage, Gabrielle; Kirchhoff, Frank; Sauter, Daniel; Hahn, Beatrice H.; Finzi, Andrés; Richard, Jonathan
Published in: mBio, 2023, ISSN 2150-7511
Publisher: ASM
DOI: 10.1128/MBIO.00789-23

Antiviral mechanisms of guanylate-binding protein 5: versatile inhibition of multiple viral glycoproteins

Author(s): Daniel Sauter; Frank Kirchhoff
Published in: mBio, 2024, ISSN 2150-7511
Publisher: ASM
DOI: 10.1128/MBIO.02374-24

Inhibition of placental trophoblast fusion by guanylate-binding protein 5

Author(s): Veronika Krchlikova, Elisabeth Braun, Johanna Weiss, Krystof Stafl, Lukas Jech, Smitha Srinivasachar Badarinarayan, Rishikesh Lotke, Martin Travnicek, Charlotte Baur, Paul Stark, Isabell Haussmann, Yueshuang Lu, Moritz Petersen, Wen Cui, Wei Wang, Bianca M. Fäger, Hannah Reisinger, Kenzo Tokunaga, Oya Cingöz, Konstantin M. J. Sparrer, Madhuri S. Salker, Jiri Hejnar, Frank Kirchhoff, Katerina Trejbalova, Daniel Sauter
Published in: Science Advances, Issue 11, 2025, ISSN 2375-2548
Publisher: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/SCIADV.ADT5388