Circular RNAs to reverse pathological remodelling of the injured heart

Project Information

REVERSE

Grant agreement ID: 101054460

DOI

10.3030/101054460

EC signature date 31 May 2022

Start date 1 October 2022

End date 30 September 2027

Funded under

• European Research Council (ERC)

Total cost

€ 2 499 375,00

EU contribution

€ 2 499 375,00

Coordinated by

MEDIZINISCHE HOCHSCHULE HANNOVER
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (13)

Living myocardial slices: walking the path towards standardization

Author(s): Jort S A van der Geest, Teun P de Boer, Cesare M Terracciano, Thomas Thum, Andreas Dendorfer, Pieter A Doevendans, Linda W van Laake, Joost P G Sluijter, Vasco Sampaio-Pinto
Published in: Cardiovascular Research, 2025, ISSN 0008-6363
Publisher: Oxford University Press (OUP)
DOI: 10.1093/CVR/CVAF079

Circular RNA circZFPM2 regulates cardiomyocyte hypertrophy and survival

Author(s): Dimyana Neufeldt, Arne Schmidt, Elisa Mohr, Dongchao Lu, Shambhabi Chatterjee, Maximilian Fuchs, Ke Xiao, Wen Pan, Sarah Cushman, Christopher Jahn, Malte Juchem, Hannah Jill Hunkler, Giuseppe Cipriano, Bjarne Jürgens, Kevin Schmidt, Sonja Groß, Mira Jung, Jeannine Hoepfner, Natalie Weber, Roger Foo, Andreas Pich, Robert Zweigerdt, Theresia Kraft, Thomas Thum, Christian Bär
Published in: Basic Research in Cardiology, Issue 119, 2024, ISSN 1435-1803
Publisher: Springer Science and Business Media LLC
DOI: 10.1007/s00395-024-01048-y

Prolonged Hypoxia in Rat Living Myocardial Slices Affects Function, Expression, and Structure

Author(s): Florian J. G. Waleczek, Giuseppe Cipriano, Jonas A. Haas, Ankita Garg, Angelika Pfanne, Annette Just, Susanne Neumüller, Jan Hegermann, Andreas Pich, Ante Radocaj, Ke Xiao, Natalie Weber, Thomas Thum
Published in: International Journal of Molecular Sciences, Issue 26, 2024, ISSN 1422-0067
Publisher: MDPI AG
DOI: 10.3390/IJMS26010218

Ex vivo modelling of cardiac injury identifies ferroptosis-related pathways as a potential therapeutic avenue for translational medicine

Author(s): Naisam Abbas, Marco Bentele, Florian J.G. Waleczek, Maximilian Fuchs, Annette Just, Angelika Pfanne, Andreas Pich, Sophie Linke, Susanne Neumüller, Angelika Stucki-Koch, Maria Jordan, Filippo Perbellini, Christopher Werlein, Wilhelm Korte, Fabio Ius, Arjang Ruhparwar, Natalie Weber, Jan Fiedler, Thomas Thum
Published in: Journal of Molecular and Cellular Cardiology, Issue 196, 2024, ISSN 0022-2828
Publisher: Elsevier BV
DOI: 10.1016/j.yjmcc.2024.09.012

Single-nucleus RNA sequencing identifies cell-type–specific effects of sodium-glucose co-transporter 2 inhibitors in human myocardial slices

Author(s): Kevin Schmidt, Maximilian Fuchs, Natalie Weber, Christopher Werlein, Jan D Schmitto, Fabio Ius, Arjang Ruhparwar, Christian Bär, Jan Fiedler, Thomas Thum
Published in: European Heart Journal, Issue 45, 2024, ISSN 0195-668X
Publisher: Oxford University Press (OUP)
DOI: 10.1093/eurheartj/ehae472

Anti-senescence therapies: a new concept to address cardiovascular disease

Author(s): Stevan D Stojanović, Thomas Thum, Johann Bauersachs
Published in: Cardiovascular Research, Issue 121, 2025, ISSN 0008-6363
Publisher: Oxford University Press (OUP)
DOI: 10.1093/CVR/CVAF030

Mechanisms of myocardial reverse remodelling and its clinical significance: A scientific statement of the ESC Working Group on Myocardial Function

Author(s): Inês Falcão‐Pires, Ana Filipa Ferreira, Fábio Trindade, Luc Bertrand, Michele Ciccarelli, Valeria Visco, Dana Dawson, Nazha Hamdani, Linda W. Van Laake, Frank Lezoualc'h, Wolfgang A. Linke, Ida G Lunde, Peter P. Rainer, Mahmoud Abdellatif, Jolanda Van der Velden, Nicola Cosentino, Alessia Paldino, Giulio Pompilio, Serena Zacchigna, Stephane Heymans, Thomas Thum, Carlo Gabriele Tocchetti
Published in: European Journal of Heart Failure, Issue 26, 2024, ISSN 1388-9842
Publisher: Wiley
DOI: 10.1002/ejhf.3264

Update on preclinical models of cancer therapy‐related cardiac dysfunction: Challenges and perspectives. A scientific statement of the Heart Failure Association (<scp>HFA</scp>) of the <scp>ESC</scp>, the <scp>ESC</scp> Council of Cardio‐Oncology, and the <scp>ESC</scp> Working Group on Cellular Biology of the Heart

Author(s): Alessandra Ghigo, Pietro Ameri, Aarti Asnani, Edoardo Bertero, Rudolf A. de Boer, Dimitrios Farmakis, Arantxa González, Stephane Heymans, Borja Ibáñez, Teresa López‐Fernández, Alexander R. Lyon, Piero Pollesello, Amina Rakisheva, Konstantinos Stellos, Katrin Streckfuss‐Bömeke, Carlo Gabriele Tocchetti, Thomas Thum, Peter van der Meer, Eva Van Rooij, Piotr Ponikowski, Marco Metra, Giuseppe Rosano, Sophie Van Linthout
Published in: European Journal of Heart Failure, 2025, ISSN 1388-9842
Publisher: Wiley
DOI: 10.1002/EJHF.3636

Ex vivo modelling of cardiac injury identifies ferroptosis-related pathways as a potential therapeutic avenue for translational medicine

Author(s): Naisam Abbas, Marco Bentele, Florian J.G. Waleczek, Maximilian Fuchs, Annette Just, Angelika Pfanne, Andreas Pich, Sophie Linke, Susanne Neumüller, Angelika Stucki-Koch, Maria Jordan, Filippo Perbellini, Christopher Werlein, Wilhelm Korte, Fabio Ius, Arjang Ruhparwar, Natalie Weber, Jan Fiedler, Thomas Thum
Published in: Journal of Molecular and Cellular Cardiology, Issue 196, 2024, ISSN 0022-2828
Publisher: Elsevier BV
DOI: 10.1016/J.YJMCC.2024.09.012

Inhibition of miR-21: cardioprotective effects in human failing myocardium <i>ex vivo</i>

Author(s): Naisam Abbas, Jonas A Haas, Ke Xiao, Maximilian Fuchs, Annette Just, Andreas Pich, Filippo Perbellini, Christopher Werlein, Fabio Ius, Arjang Ruhparwar, Jan Fiedler, Natalie Weber, Thomas Thum
Published in: European Heart Journal, Issue 45, 2024, ISSN 0195-668X
Publisher: Oxford University Press (OUP)
DOI: 10.1093/eurheartj/ehae102

Activation of the integrated stress response rewires cardiac metabolism in Barth syndrome

Author(s): Ilona Kutschka, Edoardo Bertero, Christina Wasmus, Ke Xiao, Lifeng Yang, Xinyu Chen, Yasuhiro Oshima, Marcus Fischer, Manuela Erk, Berkan Arslan, Lin Alhasan, Daria Grosser, Katharina J. Ermer, Alexander Nickel, Michael Kohlhaas, Hanna Eberl, Sabine Rebs, Katrin Streckfuss-Bömeke, Werner Schmitz, Peter Rehling, Thomas Thum, Takahiro Higuchi, Joshua Rabinowitz, Christoph Maack, Jan Dudek
Published in: Basic Research in Cardiology, Issue 118, 2023, ISSN 1435-1803
Publisher: Springer Science and Business Media LLC
DOI: 10.1007/s00395-023-01017-x

State of the art and perspectives of gene therapy in heart failure. A scientific statement of the Heart Failure Association of the <scp>ESC</scp>, the <scp>ESC</scp> Council on Cardiovascular Genomics and the <scp>ESC</scp> Working Group on Myocardial &amp; Pericardial Diseases

Author(s): Sophie Van Linthout, Konstantinos Stellos, Mauro Giacca, Edoardo Bertero, Antonio Cannata, Lucie Carrier, Pablo Garcia‐Pavia, Alessandra Ghigo, Arantxa González, Kristina H. Haugaa, Massimo Imazio, Luis R. Lopes, Patrick Most, Piero Pollesello, Heribert Schunkert, Katrin Streckfuss‐Bömeke, Thomas Thum, Carlo Gabriele Tocchetti, Carsten Tschöpe, Peter van der Meer, Eva van Rooij, Marco Metra, Giuseppe M.C. Rosano, Stephane Heymans
Published in: European Journal of Heart Failure, Issue 27, 2025, ISSN 1388-9842
Publisher: Wiley
DOI: 10.1002/EJHF.3516

Cardiovascular complications of diabetes: role of non-coding RNAs in the crosstalk between immune and cardiovascular systems

Author(s): Gaia Spinetti, Martina Mutoli, Simona Greco, Federica Riccio, Soumaya Ben-Aicha, Franziska Kenneweg, Amela Jusic, David de Gonzalo-Calvo, Anne Yaël Nossent, Susana Novella, Georgios Kararigas, Thomas Thum, Costanza Emanueli, Yvan Devaux, Fabio Martelli
Published in: Cardiovascular Diabetology, Issue 22, 2023, ISSN 1475-2840
Publisher: Springer Science and Business Media LLC
DOI: 10.1186/s12933-023-01842-3