Circular RNAs to reverse pathological remodelling of the injured heart

Información del proyecto

REVERSE

Identificador del acuerdo de subvención: 101054460

DOI

10.3030/101054460

Fecha de la firma de la CE 31 Mayo 2022

Fecha de inicio 1 Octubre 2022

Fecha de finalización 30 Septiembre 2027

Financiado con arreglo a

• European Research Council (ERC)

Coste total

€ 2 499 375,00

Aportación de la UE

€ 2 499 375,00

Coordinado por

MEDIZINISCHE HOCHSCHULE HANNOVER
Germany

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (13)

Living myocardial slices: walking the path towards standardization

Autores: Jort S A van der Geest, Teun P de Boer, Cesare M Terracciano, Thomas Thum, Andreas Dendorfer, Pieter A Doevendans, Linda W van Laake, Joost P G Sluijter, Vasco Sampaio-Pinto
Publicado en: Cardiovascular Research, 2025, ISSN 0008-6363
Editor: Oxford University Press (OUP)
DOI: 10.1093/CVR/CVAF079

Circular RNA circZFPM2 regulates cardiomyocyte hypertrophy and survival

Autores: Dimyana Neufeldt, Arne Schmidt, Elisa Mohr, Dongchao Lu, Shambhabi Chatterjee, Maximilian Fuchs, Ke Xiao, Wen Pan, Sarah Cushman, Christopher Jahn, Malte Juchem, Hannah Jill Hunkler, Giuseppe Cipriano, Bjarne Jürgens, Kevin Schmidt, Sonja Groß, Mira Jung, Jeannine Hoepfner, Natalie Weber, Roger Foo, Andreas Pich, Robert Zweigerdt, Theresia Kraft, Thomas Thum, Christian Bär
Publicado en: Basic Research in Cardiology, Edición 119, 2024, ISSN 1435-1803
Editor: Springer Science and Business Media LLC
DOI: 10.1007/s00395-024-01048-y

Prolonged Hypoxia in Rat Living Myocardial Slices Affects Function, Expression, and Structure

Autores: Florian J. G. Waleczek, Giuseppe Cipriano, Jonas A. Haas, Ankita Garg, Angelika Pfanne, Annette Just, Susanne Neumüller, Jan Hegermann, Andreas Pich, Ante Radocaj, Ke Xiao, Natalie Weber, Thomas Thum
Publicado en: International Journal of Molecular Sciences, Edición 26, 2024, ISSN 1422-0067
Editor: MDPI AG
DOI: 10.3390/IJMS26010218

Ex vivo modelling of cardiac injury identifies ferroptosis-related pathways as a potential therapeutic avenue for translational medicine

Autores: Naisam Abbas, Marco Bentele, Florian J.G. Waleczek, Maximilian Fuchs, Annette Just, Angelika Pfanne, Andreas Pich, Sophie Linke, Susanne Neumüller, Angelika Stucki-Koch, Maria Jordan, Filippo Perbellini, Christopher Werlein, Wilhelm Korte, Fabio Ius, Arjang Ruhparwar, Natalie Weber, Jan Fiedler, Thomas Thum
Publicado en: Journal of Molecular and Cellular Cardiology, Edición 196, 2024, ISSN 0022-2828
Editor: Elsevier BV
DOI: 10.1016/j.yjmcc.2024.09.012

Single-nucleus RNA sequencing identifies cell-type–specific effects of sodium-glucose co-transporter 2 inhibitors in human myocardial slices

Autores: Kevin Schmidt, Maximilian Fuchs, Natalie Weber, Christopher Werlein, Jan D Schmitto, Fabio Ius, Arjang Ruhparwar, Christian Bär, Jan Fiedler, Thomas Thum
Publicado en: European Heart Journal, Edición 45, 2024, ISSN 0195-668X
Editor: Oxford University Press (OUP)
DOI: 10.1093/eurheartj/ehae472

Anti-senescence therapies: a new concept to address cardiovascular disease

Autores: Stevan D Stojanović, Thomas Thum, Johann Bauersachs
Publicado en: Cardiovascular Research, Edición 121, 2025, ISSN 0008-6363
Editor: Oxford University Press (OUP)
DOI: 10.1093/CVR/CVAF030

Mechanisms of myocardial reverse remodelling and its clinical significance: A scientific statement of the ESC Working Group on Myocardial Function

Autores: Inês Falcão‐Pires, Ana Filipa Ferreira, Fábio Trindade, Luc Bertrand, Michele Ciccarelli, Valeria Visco, Dana Dawson, Nazha Hamdani, Linda W. Van Laake, Frank Lezoualc'h, Wolfgang A. Linke, Ida G Lunde, Peter P. Rainer, Mahmoud Abdellatif, Jolanda Van der Velden, Nicola Cosentino, Alessia Paldino, Giulio Pompilio, Serena Zacchigna, Stephane Heymans, Thomas Thum, Carlo Gabriele Tocchetti
Publicado en: European Journal of Heart Failure, Edición 26, 2024, ISSN 1388-9842
Editor: Wiley
DOI: 10.1002/ejhf.3264

Update on preclinical models of cancer therapy‐related cardiac dysfunction: Challenges and perspectives. A scientific statement of the Heart Failure Association (<scp>HFA</scp>) of the <scp>ESC</scp>, the <scp>ESC</scp> Council of Cardio‐Oncology, and the <scp>ESC</scp> Working Group on Cellular Biology of the Heart

Autores: Alessandra Ghigo, Pietro Ameri, Aarti Asnani, Edoardo Bertero, Rudolf A. de Boer, Dimitrios Farmakis, Arantxa González, Stephane Heymans, Borja Ibáñez, Teresa López‐Fernández, Alexander R. Lyon, Piero Pollesello, Amina Rakisheva, Konstantinos Stellos, Katrin Streckfuss‐Bömeke, Carlo Gabriele Tocchetti, Thomas Thum, Peter van der Meer, Eva Van Rooij, Piotr Ponikowski, Marco Metra, Giuseppe Rosano, Sophie Van Linthout
Publicado en: European Journal of Heart Failure, 2025, ISSN 1388-9842
Editor: Wiley
DOI: 10.1002/EJHF.3636

Ex vivo modelling of cardiac injury identifies ferroptosis-related pathways as a potential therapeutic avenue for translational medicine

Autores: Naisam Abbas, Marco Bentele, Florian J.G. Waleczek, Maximilian Fuchs, Annette Just, Angelika Pfanne, Andreas Pich, Sophie Linke, Susanne Neumüller, Angelika Stucki-Koch, Maria Jordan, Filippo Perbellini, Christopher Werlein, Wilhelm Korte, Fabio Ius, Arjang Ruhparwar, Natalie Weber, Jan Fiedler, Thomas Thum
Publicado en: Journal of Molecular and Cellular Cardiology, Edición 196, 2024, ISSN 0022-2828
Editor: Elsevier BV
DOI: 10.1016/J.YJMCC.2024.09.012

Inhibition of miR-21: cardioprotective effects in human failing myocardium <i>ex vivo</i>

Autores: Naisam Abbas, Jonas A Haas, Ke Xiao, Maximilian Fuchs, Annette Just, Andreas Pich, Filippo Perbellini, Christopher Werlein, Fabio Ius, Arjang Ruhparwar, Jan Fiedler, Natalie Weber, Thomas Thum
Publicado en: European Heart Journal, Edición 45, 2024, ISSN 0195-668X
Editor: Oxford University Press (OUP)
DOI: 10.1093/eurheartj/ehae102

Activation of the integrated stress response rewires cardiac metabolism in Barth syndrome

Autores: Ilona Kutschka, Edoardo Bertero, Christina Wasmus, Ke Xiao, Lifeng Yang, Xinyu Chen, Yasuhiro Oshima, Marcus Fischer, Manuela Erk, Berkan Arslan, Lin Alhasan, Daria Grosser, Katharina J. Ermer, Alexander Nickel, Michael Kohlhaas, Hanna Eberl, Sabine Rebs, Katrin Streckfuss-Bömeke, Werner Schmitz, Peter Rehling, Thomas Thum, Takahiro Higuchi, Joshua Rabinowitz, Christoph Maack, Jan Dudek
Publicado en: Basic Research in Cardiology, Edición 118, 2023, ISSN 1435-1803
Editor: Springer Science and Business Media LLC
DOI: 10.1007/s00395-023-01017-x

State of the art and perspectives of gene therapy in heart failure. A scientific statement of the Heart Failure Association of the <scp>ESC</scp>, the <scp>ESC</scp> Council on Cardiovascular Genomics and the <scp>ESC</scp> Working Group on Myocardial &amp; Pericardial Diseases

Autores: Sophie Van Linthout, Konstantinos Stellos, Mauro Giacca, Edoardo Bertero, Antonio Cannata, Lucie Carrier, Pablo Garcia‐Pavia, Alessandra Ghigo, Arantxa González, Kristina H. Haugaa, Massimo Imazio, Luis R. Lopes, Patrick Most, Piero Pollesello, Heribert Schunkert, Katrin Streckfuss‐Bömeke, Thomas Thum, Carlo Gabriele Tocchetti, Carsten Tschöpe, Peter van der Meer, Eva van Rooij, Marco Metra, Giuseppe M.C. Rosano, Stephane Heymans
Publicado en: European Journal of Heart Failure, Edición 27, 2025, ISSN 1388-9842
Editor: Wiley
DOI: 10.1002/EJHF.3516

Cardiovascular complications of diabetes: role of non-coding RNAs in the crosstalk between immune and cardiovascular systems

Autores: Gaia Spinetti, Martina Mutoli, Simona Greco, Federica Riccio, Soumaya Ben-Aicha, Franziska Kenneweg, Amela Jusic, David de Gonzalo-Calvo, Anne Yaël Nossent, Susana Novella, Georgios Kararigas, Thomas Thum, Costanza Emanueli, Yvan Devaux, Fabio Martelli
Publicado en: Cardiovascular Diabetology, Edición 22, 2023, ISSN 1475-2840
Editor: Springer Science and Business Media LLC
DOI: 10.1186/s12933-023-01842-3