ENGINEERING CELLULAR SELF‐ORGANISATION BY CONTROLLING THE IMMUNO-MECHANICAL INTERPLAY

Project Information

Immuno-mechanics

Grant agreement ID: 101054501

DOI 10.3030/101054501

EC signature date 18 August 2022

Start date 1 January 2023

End date 31 December 2027

Funded under

• European Research Council (ERC)

Total cost € 2 490 725,00

EU contribution € 2 490 725,00

Coordinated by

CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (16)

Mechanical heterogeneity in a soft biomaterial niche controls BMP2 signaling

Author(s): Erik Brauer, Aaron Herrera, Raphaela Fritsche-Guenther, Sophie Görlitz, Hans Leemhuis, Petra Knaus, Jennifer A. Kirwan, Georg N. Duda, Ansgar Petersen
Published in: Biomaterials, Issue 309, 2024, ISSN 0142-9612
Publisher: Elsevier BV
DOI: 10.1016/J.BIOMATERIALS.2024.122614

The global evolution and impact of systems biology and artificial intelligence in stem cell research and therapeutics development: a scoping review

Author(s): Thayna Silva-Sousa, Júlia Nakanishi Usuda, Nada Al-Arawe, Francisca Frias, Irene Hinterseher, Rusan Catar, Christian Luecht, Katarina Riesner, Alexander Hackel, Lena F Schimke, Haroldo Dutra Dias, Igor Salerno Filgueiras, Helder I Nakaya, Niels Olsen Saraiva Camara, Stefan Fischer, Gabriela Riemekasten, Olle Ringdén, Olaf Penack, Tobias Winkler, Georg Duda, Dennyson Leandro M Fonseca, Otávio Cabral-Marques, Guido Moll
Published in: Stem Cells, Issue 42, 2024, ISSN 1066-5099
Publisher: Oxford University Press (OUP)
DOI: 10.1093/STMCLS/SXAE054

Pronounced impairment of B cell differentiation during bone regeneration in adult immune experienced mice

Author(s): Mireille Ngokingha Tchouto, Christian H. Bucher, Ann-Kathrin Mess, Simon Haas, Katharina Schmidt-Bleek, Georg N. Duda, Dieter Beule, Miha Milek
Published in: Frontiers in Immunology, Issue 16, 2025, ISSN 1664-3224
Publisher: Frontiers Media SA
DOI: 10.3389/FIMMU.2025.1511902

The enhancer landscape predetermines the skeletal regeneration capacity of stromal cells

Author(s): Sarah Hochmann, Kristy Ou, Rodolphe Poupardin, Michaela Mittermeir, Martin Textor, Salaheddine Ali, Martin Wolf, Agnes Ellinghaus, Dorit Jacobi, Juri A. J. Elmiger, Samantha Donsante, Mara Riminucci, Richard Schäfer, Uwe Kornak, Oliver Klein, Katharina Schallmoser, Katharina Schmidt-Bleek, Georg N. Duda, Julia K. Polansky, Sven Geissler, Dirk Strunk
Published in: Science Translational Medicine, Issue 15, 2023, ISSN 1946-6234
Publisher: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/SCITRANSLMED.ABM7477

Reduced Bone Regeneration in Rats With Type 2 Diabetes Mellitus as a Result of Impaired Stromal Cell and Osteoblast Function—A Computer Modeling Study

Author(s): Mahdi Jaber, Lorenz C Hofbauer, Christine Hofbauer, Georg N Duda, Sara Checa
Published in: JBMR Plus, Issue 7, 2023, ISSN 2473-4039
Publisher: Oxford University Press (OUP)
DOI: 10.1002/JBM4.10809

A comprehensive molecular profiling approach reveals metabolic alterations that steer bone tissue regeneration

Author(s): Julia Löffler, Anne Noom, Agnes Ellinghaus, Anke Dienelt, Stefan Kempa, Georg N. Duda
Published in: Communications Biology, Issue 6, 2023, ISSN 2399-3642
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S42003-023-04652-1

Water and ions binding to extracellular matrix drives stress relaxation, aiding MRI detection of swelling-associated pathology

Author(s): Matthias R. Kollert, Martin Krämer, Nicholas M. Brisson, Victoria Schemenz, Serafeim Tsitsilonis, Taimoor H. Qazi, Peter Fratzl, Viola Vogel, Jürgen R. Reichenbach, Georg N. Duda
Published in: Nature Biomedical Engineering, 2025, ISSN 2157-846X
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41551-025-01369-W

Periprosthetic Joint Infections of the Knee Lastingly Impact the Bone Homeostasis

Author(s): Evgeniya Bandick, Lara Biedermann, Yi Ren, Stefanie Donner, Mario Thiele, Gabriela Korus, Serafeim Tsitsilonis, Michael Müller, Georg Duda, Carsten Perka, Arne Kienzle
Published in: Journal of Bone and Mineral Research, Issue 38, 2023, ISSN 0884-0431
Publisher: Oxford University Press (OUP)
DOI: 10.1002/JBMR.4892

Increased β ₂ -adrenergic signaling promotes fracture healing through callus neovascularization in mice

Author(s): Denise Jahn, Paul Richard Knapstein, Ellen Otto, Paul Köhli, Jan Sevecke, Frank Graef, Christine Graffmann, Melanie Fuchs, Shan Jiang, Mayla Rickert, Cordula Erdmann, Jessika Appelt, Lawik Revend, Quin Küttner, Jason Witte, Adibeh Rahmani, Georg Duda, Weixin Xie, Antonia Donat, Thorsten Schinke, Andranik Ivanov, Mireille Ngokingha Tchouto, Dieter Beule, Karl-Heinz Frosch, Anke Baranowsky, Serafeim Tsitsilonis, Johannes Keller
Published in: Science Translational Medicine, Issue 16, 2024, ISSN 1946-6234
Publisher: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/SCITRANSLMED.ADK9129

Elastin stabilization prevents impaired biomechanics in human pulmonary arteries and pulmonary hypertension in rats with left heart disease

Author(s): Mariya M. Kucherenko, Pengchao Sang, Juquan Yao, Tara Gransar, Saphala Dhital, Jana Grune, Szandor Simmons, Laura Michalick, Dag Wulsten, Mario Thiele, Orr Shomroni, Felix Hennig, Ruhi Yeter, Natalia Solowjowa, Gabriela Salinas, Georg N. Duda, Volkmar Falk, Naren R. Vyavahare, Wolfgang M. Kuebler, Christoph Knosalla
Published in: Nature Communications, Issue 14, 2023, ISSN 2041-1723
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41467-023-39934-Z

External mechanical loading overrules cell-cell mechanical communication in sprouting angiogenesis during early bone regeneration

Author(s): Chiara Dazzi, Julia Mehl, Mounir Benamar, Holger Gerhardt, Petra Knaus, Georg N. Duda, Sara Checa
Published in: PLOS Computational Biology, Issue 19, 2023, ISSN 1553-7358
Publisher: Public Library of Science (PLoS)
DOI: 10.1371/JOURNAL.PCBI.1011647

Caloric restriction reduces trabecular bone loss during aging and improves bone marrow adipocyte endocrine function in male mice

Author(s): Charlotte Rinne, George A. Soultoukis, Masoome Oveisi, Marina Leer, Oskar Schmidt-Bleek, Lisa-Marie Burkhardt, Christian H. Bucher, Eman Abou Moussa, Melanie Makhlouf, Georg N. Duda, Luis R. Saraiva, Katharina Schmidt-Bleek, Tim J. Schulz
Published in: Frontiers in Endocrinology, Issue 15, 2024, ISSN 1664-2392
Publisher: Frontiers Media SA
DOI: 10.3389/FENDO.2024.1394263

External Mechanical Stability Regulates Hematoma Vascularization in Bone Healing Rather than Endothelial YAP/TAZ Mechanotransduction

Author(s): Julia Mehl, Saeed Khomeijani Farahani, Erik Brauer, Alexandra Klaus‐Bergmann, Tobias Thiele, Agnes Ellinghaus, Eireen Bartels‐Klein, Katharina Koch, Katharina Schmidt‐Bleek, Ansgar Petersen, Holger Gerhardt, Viola Vogel, Georg N. Duda
Published in: Advanced Science, Issue 11, 2024, ISSN 2198-3844
Publisher: Wiley
DOI: 10.1002/ADVS.202307050

Complex Spatio-Temporal Interplay of Distinct Immune and Bone Cell Subsets during Bone Fracture Healing

Author(s): Claudia Schlundt, Radost A. Saß, Christian H. Bucher, Sabine Bartosch, Anja E. Hauser, Hans-Dieter Volk, Georg N. Duda, Katharina Schmidt-Bleek
Published in: Cells, Issue 13, 2023, ISSN 2073-4409
Publisher: MDPI AG
DOI: 10.3390/CELLS13010040

Hydrogels with stiffness-degradation spatial patterns control anisotropic 3D cell response

Author(s): Claudia A. Garrido, Daniela S. Garske, Mario Thiele, Shahrouz Amini, Samik Real, Georg N. Duda, Katharina Schmidt-Bleek, Amaia Cipitria
Published in: Biomaterials Advances, Issue 151, 2023, ISSN 2772-9508
Publisher: Elsevier BV
DOI: 10.1016/J.BIOADV.2023.213423

Pro-Resolving Mediators in Rotator Cuff Disease: How Is the Bursa Involved?

Author(s): Franka Klatte-Schulz, Nicole Bormann, Aysha Bonell, Jasmin Al-Michref, Hoang Le Nguyen, Pascal Klöckner, Kathi Thiele, Philipp Moroder, Martina Seifert, Birgit Sawitzki, Britt Wildemann, Georg N. Duda
Published in: Cells, Issue 13, 2023, ISSN 2073-4409
Publisher: MDPI AG
DOI: 10.3390/CELLS13010017