ENGINEERING CELLULAR SELF‐ORGANISATION BY CONTROLLING THE IMMUNO-MECHANICAL INTERPLAY

Información del proyecto

Immuno-mechanics

Identificador del acuerdo de subvención: 101054501

DOI

10.3030/101054501

Fecha de la firma de la CE 18 Agosto 2022

Fecha de inicio 1 Enero 2023

Fecha de finalización 31 Diciembre 2027

Financiado con arreglo a

• European Research Council (ERC)

Coste total

€ 2 490 725,00

Aportación de la UE

€ 2 490 725,00

Coordinado por

CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Germany

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (16)

Mechanical heterogeneity in a soft biomaterial niche controls BMP2 signaling

Autores: Erik Brauer, Aaron Herrera, Raphaela Fritsche-Guenther, Sophie Görlitz, Hans Leemhuis, Petra Knaus, Jennifer A. Kirwan, Georg N. Duda, Ansgar Petersen
Publicado en: Biomaterials, Edición 309, 2024, ISSN 0142-9612
Editor: Elsevier BV
DOI: 10.1016/J.BIOMATERIALS.2024.122614

The global evolution and impact of systems biology and artificial intelligence in stem cell research and therapeutics development: a scoping review

Autores: Thayna Silva-Sousa, Júlia Nakanishi Usuda, Nada Al-Arawe, Francisca Frias, Irene Hinterseher, Rusan Catar, Christian Luecht, Katarina Riesner, Alexander Hackel, Lena F Schimke, Haroldo Dutra Dias, Igor Salerno Filgueiras, Helder I Nakaya, Niels Olsen Saraiva Camara, Stefan Fischer, Gabriela Riemekasten, Olle Ringdén, Olaf Penack, Tobias Winkler, Georg Duda, Dennyson Leandro M Fonseca, Otávio Cabral-Marques, Guido Moll
Publicado en: Stem Cells, Edición 42, 2024, ISSN 1066-5099
Editor: Oxford University Press (OUP)
DOI: 10.1093/STMCLS/SXAE054

Pronounced impairment of B cell differentiation during bone regeneration in adult immune experienced mice

Autores: Mireille Ngokingha Tchouto, Christian H. Bucher, Ann-Kathrin Mess, Simon Haas, Katharina Schmidt-Bleek, Georg N. Duda, Dieter Beule, Miha Milek
Publicado en: Frontiers in Immunology, Edición 16, 2025, ISSN 1664-3224
Editor: Frontiers Media SA
DOI: 10.3389/FIMMU.2025.1511902

The enhancer landscape predetermines the skeletal regeneration capacity of stromal cells

Autores: Sarah Hochmann, Kristy Ou, Rodolphe Poupardin, Michaela Mittermeir, Martin Textor, Salaheddine Ali, Martin Wolf, Agnes Ellinghaus, Dorit Jacobi, Juri A. J. Elmiger, Samantha Donsante, Mara Riminucci, Richard Schäfer, Uwe Kornak, Oliver Klein, Katharina Schallmoser, Katharina Schmidt-Bleek, Georg N. Duda, Julia K. Polansky, Sven Geissler, Dirk Strunk
Publicado en: Science Translational Medicine, Edición 15, 2023, ISSN 1946-6234
Editor: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/SCITRANSLMED.ABM7477

Reduced Bone Regeneration in Rats With Type 2 Diabetes Mellitus as a Result of Impaired Stromal Cell and Osteoblast Function—A Computer Modeling Study

Autores: Mahdi Jaber, Lorenz C Hofbauer, Christine Hofbauer, Georg N Duda, Sara Checa
Publicado en: JBMR Plus, Edición 7, 2023, ISSN 2473-4039
Editor: Oxford University Press (OUP)
DOI: 10.1002/JBM4.10809

A comprehensive molecular profiling approach reveals metabolic alterations that steer bone tissue regeneration

Autores: Julia Löffler, Anne Noom, Agnes Ellinghaus, Anke Dienelt, Stefan Kempa, Georg N. Duda
Publicado en: Communications Biology, Edición 6, 2023, ISSN 2399-3642
Editor: Springer Science and Business Media LLC
DOI: 10.1038/S42003-023-04652-1

Water and ions binding to extracellular matrix drives stress relaxation, aiding MRI detection of swelling-associated pathology

Autores: Matthias R. Kollert, Martin Krämer, Nicholas M. Brisson, Victoria Schemenz, Serafeim Tsitsilonis, Taimoor H. Qazi, Peter Fratzl, Viola Vogel, Jürgen R. Reichenbach, Georg N. Duda
Publicado en: Nature Biomedical Engineering, 2025, ISSN 2157-846X
Editor: Springer Science and Business Media LLC
DOI: 10.1038/S41551-025-01369-W

Periprosthetic Joint Infections of the Knee Lastingly Impact the Bone Homeostasis

Autores: Evgeniya Bandick, Lara Biedermann, Yi Ren, Stefanie Donner, Mario Thiele, Gabriela Korus, Serafeim Tsitsilonis, Michael Müller, Georg Duda, Carsten Perka, Arne Kienzle
Publicado en: Journal of Bone and Mineral Research, Edición 38, 2023, ISSN 0884-0431
Editor: Oxford University Press (OUP)
DOI: 10.1002/JBMR.4892

Increased β ₂ -adrenergic signaling promotes fracture healing through callus neovascularization in mice

Autores: Denise Jahn, Paul Richard Knapstein, Ellen Otto, Paul Köhli, Jan Sevecke, Frank Graef, Christine Graffmann, Melanie Fuchs, Shan Jiang, Mayla Rickert, Cordula Erdmann, Jessika Appelt, Lawik Revend, Quin Küttner, Jason Witte, Adibeh Rahmani, Georg Duda, Weixin Xie, Antonia Donat, Thorsten Schinke, Andranik Ivanov, Mireille Ngokingha Tchouto, Dieter Beule, Karl-Heinz Frosch, Anke Baranowsky, Serafeim Tsitsilonis, Johannes Keller
Publicado en: Science Translational Medicine, Edición 16, 2024, ISSN 1946-6234
Editor: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/SCITRANSLMED.ADK9129

Elastin stabilization prevents impaired biomechanics in human pulmonary arteries and pulmonary hypertension in rats with left heart disease

Autores: Mariya M. Kucherenko, Pengchao Sang, Juquan Yao, Tara Gransar, Saphala Dhital, Jana Grune, Szandor Simmons, Laura Michalick, Dag Wulsten, Mario Thiele, Orr Shomroni, Felix Hennig, Ruhi Yeter, Natalia Solowjowa, Gabriela Salinas, Georg N. Duda, Volkmar Falk, Naren R. Vyavahare, Wolfgang M. Kuebler, Christoph Knosalla
Publicado en: Nature Communications, Edición 14, 2023, ISSN 2041-1723
Editor: Springer Science and Business Media LLC
DOI: 10.1038/S41467-023-39934-Z

External mechanical loading overrules cell-cell mechanical communication in sprouting angiogenesis during early bone regeneration

Autores: Chiara Dazzi, Julia Mehl, Mounir Benamar, Holger Gerhardt, Petra Knaus, Georg N. Duda, Sara Checa
Publicado en: PLOS Computational Biology, Edición 19, 2023, ISSN 1553-7358
Editor: Public Library of Science (PLoS)
DOI: 10.1371/JOURNAL.PCBI.1011647

Caloric restriction reduces trabecular bone loss during aging and improves bone marrow adipocyte endocrine function in male mice

Autores: Charlotte Rinne, George A. Soultoukis, Masoome Oveisi, Marina Leer, Oskar Schmidt-Bleek, Lisa-Marie Burkhardt, Christian H. Bucher, Eman Abou Moussa, Melanie Makhlouf, Georg N. Duda, Luis R. Saraiva, Katharina Schmidt-Bleek, Tim J. Schulz
Publicado en: Frontiers in Endocrinology, Edición 15, 2024, ISSN 1664-2392
Editor: Frontiers Media SA
DOI: 10.3389/FENDO.2024.1394263

External Mechanical Stability Regulates Hematoma Vascularization in Bone Healing Rather than Endothelial YAP/TAZ Mechanotransduction

Autores: Julia Mehl, Saeed Khomeijani Farahani, Erik Brauer, Alexandra Klaus‐Bergmann, Tobias Thiele, Agnes Ellinghaus, Eireen Bartels‐Klein, Katharina Koch, Katharina Schmidt‐Bleek, Ansgar Petersen, Holger Gerhardt, Viola Vogel, Georg N. Duda
Publicado en: Advanced Science, Edición 11, 2024, ISSN 2198-3844
Editor: Wiley
DOI: 10.1002/ADVS.202307050

Complex Spatio-Temporal Interplay of Distinct Immune and Bone Cell Subsets during Bone Fracture Healing

Autores: Claudia Schlundt, Radost A. Saß, Christian H. Bucher, Sabine Bartosch, Anja E. Hauser, Hans-Dieter Volk, Georg N. Duda, Katharina Schmidt-Bleek
Publicado en: Cells, Edición 13, 2023, ISSN 2073-4409
Editor: MDPI AG
DOI: 10.3390/CELLS13010040

Hydrogels with stiffness-degradation spatial patterns control anisotropic 3D cell response

Autores: Claudia A. Garrido, Daniela S. Garske, Mario Thiele, Shahrouz Amini, Samik Real, Georg N. Duda, Katharina Schmidt-Bleek, Amaia Cipitria
Publicado en: Biomaterials Advances, Edición 151, 2023, ISSN 2772-9508
Editor: Elsevier BV
DOI: 10.1016/J.BIOADV.2023.213423

Pro-Resolving Mediators in Rotator Cuff Disease: How Is the Bursa Involved?

Autores: Franka Klatte-Schulz, Nicole Bormann, Aysha Bonell, Jasmin Al-Michref, Hoang Le Nguyen, Pascal Klöckner, Kathi Thiele, Philipp Moroder, Martina Seifert, Birgit Sawitzki, Britt Wildemann, Georg N. Duda
Publicado en: Cells, Edición 13, 2023, ISSN 2073-4409
Editor: MDPI AG
DOI: 10.3390/CELLS13010017