Project description DEENESFRITPL Bacterial peptides as novel antimicrobial agents The ability of microorganisms to withstand treatment with antimicrobial agents is known as antimicrobial resistance (AMR) and poses a significant health threat. Given the absence of new drugs in the pharmaceutical pipeline, AMR threatens the outcome of medical treatments. Funded by the European Research Council, the BACtheWINNER project focuses on bacteriocins, small antibacterial peptides encoded by the bacterial genome, as novel antimicrobial agents. Bacteriocins may have a narrow or broad inhibition spectrum and can be improved by molecular genetics including peptide engineering. The project will pave the way for the generation of a new family of therapeutics against dangerous resistant pathogens. Show the project objective Hide the project objective Objective Antimicrobial resistance (AMR) is an ongoing global crisis exacerbated by lack of discovery of novel antimicrobials and absence of investment/innovation in pipelines by the pharmaceutical industry. New alternatives that are target-specific and do not cause collateral damage to the microbiome would revolutionise human and animal health. Bacteriocins are small antibacterial peptides produced by bacteria that are gene-encoded and can be narrow or broad spectrum. They have potential for development of new antimicrobial molecules through discovery and protein engineering resulting in potent, targeted antimicrobials. They have many possible applications including treatment of gut and topical infections, and microbiome editing. However, basic research issues stand in the way of their exploitation including low production levels often in unsuitable hosts, resistance development in bacterial targets, and inadequate potency/inhibition spectrum. The main aim of BACtheWINNER is to develop bacteriocins as novel antimicrobials by solving these challenges through combining and innovating state-of-the-art technologies in peptide bioengineering and molecular genetics, which will lay the foundation for the generation of this new family of therapeutics that target WHO and CDC priority pathogens and undesirable microbiota. To achieve this, a four-phase bacteriocin discovery and development pipeline will be implemented which takes new and existing bacteriocins and improves them through bioengineering, develops optimal combinations, (over-)produces them in desirable hosts, and validates their use in preclinical models of human infection and disease. This will pave the way for their development as precision microbiome tools and antimicrobials against AMR pathogens. We bring together unique expertise necessary to deliver this project by combining bacteriocin and microbiome research with genetic manipulation of food and gut bacteria. Fields of science natural sciencesbiological sciencesgeneticsnatural sciencesbiological sciencesmolecular biologymolecular geneticsnatural sciencesbiological sciencesmicrobiologybacteriologymedical and health sciencesmedical biotechnologygenetic engineeringmedical and health sciencesbasic medicinepharmacology and pharmacydrug resistanceantibiotic resistance Keywords bacteriocin microbiome bioengineering Programme(s) HORIZON.1.1 - European Research Council (ERC) Main Programme Topic(s) ERC-2021-ADG - ERC ADVANCED GRANTS Call for proposal ERC-2021-ADG See other projects for this call Funding Scheme HORIZON-ERC - HORIZON ERC Grants Host institution UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK Net EU contribution € 2 302 431,25 Address WESTERN ROAD T12 YN60 Cork Ireland See on map Region Ireland Southern South-East Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 2 302 431,25 Beneficiaries (2) Sort alphabetically Sort by Net EU contribution Expand all Collapse all UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK Ireland Net EU contribution € 2 302 431,25 Address WESTERN ROAD T12 YN60 Cork See on map Region Ireland Southern South-East Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 2 302 431,25 TEAGASC - AGRICULTURE AND FOOD DEVELOPMENT AUTHORITY Ireland Net EU contribution € 197 568,75 Address Oak Park R93 Carlow See on map Region Ireland Southern South-East Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 197 568,75
