Bacteriocins from interbacterial warfare as antibiotic alternative

Project Information

BACtheWINNER

Grant agreement ID: 101054719

DOI

10.3030/101054719

EC signature date 1 December 2022

Start date 1 April 2023

End date 31 March 2028

Funded under

• European Research Council (ERC)

Total cost

€ 2 500 000,00

EU contribution

€ 2 500 000,00

Coordinated by

UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK
Ireland

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (23)

Anionic liposome formulation for oral delivery of thuricin CD, a potential antimicrobial peptide therapeutic.

Author(s): Viera Herrera C, O'Connor PM, Ratrey P, Paul Ross R, Hill C, Hudson SP.
Published in: International Journal of Pharmaceutics, 2024, ISSN 1873-3476
Publisher: Elsevier
DOI: 10.1016/j.ijpharm.2024.123918

Promiscuous, persistent and problematic: insights into current enterococcal genomics to guide therapeutic strategy

Author(s): Hourigan D, Stefanovic E, Hill C, Ross RP.
Published in: BMC Microbiology, 2024, ISSN 1471-2180
Publisher: Springer Nature
DOI: 10.1186/s12866-024-03243-2

The Marine Fish Gut Microbiome as a Source of Novel Bacteriocins

Author(s): Uniacke-Lowe S, Stanton C, Hill C, Ross RP.
Published in: Microorganisms, 2024, ISSN 2076-2607
Publisher: MDPI
DOI: 10.3390/microorganisms12071346

Bacteriocin diversity, function, discovery and application as antimicrobials.

Author(s): Sugrue I, Ross RP, Hill C.
Published in: Nature Reviews Microbiology, 2024, ISSN 1740-1534
Publisher: Springer Nature
DOI: 10.1038/s41579-024-01045-x

Interplay between inflammatory bowel disease therapeutics and the gut microbiome reveals opportunities for novel treatment approaches

Author(s): O’ Reilly C, Mills S, Rea MC, Lavelle A, Ghosh S, Hill C, Ross RP
Published in: Microbiome Research Reports, 2023, ISSN 2771-5965
Publisher: OAE Publishing
DOI: 10.20517/mrr.2023.41

Raffinocyclicin is a novel plasmid-encoded circular bacteriocin produced by Lactococcus raffinolactis with broad-spectrum activity against many gram-positive food pathogens

Author(s): Miceli de Farias F, O’ Connor PM, Buttimer C, Kamilari E, Soria MC, Johnson CN, Deliephan A, Hill D, Fursenko O, Wiese J, Draper LA, Stanton C, Hill C, Ross RP
Published in: Applied and Environmental Microbiology, 2024, ISSN 1098-5336
Publisher: American Society for Microbiology
DOI: 10.1128/aem.00809-24

Scientific Reports

Author(s): Felipe Miceli de Farias; Maria Cecilia Soria; Paula M. O’Connor; Xiaohui Huang; Colin Buttimer; Eleni Kamilari; Aiswariya Deliephan; Daragh Hill; Oxana Fursenko; Jonathan Wiese; Lorraine Draper; Catherine Stanton; Colin Hill; R. Paul Ross
Published in: Scientific Reports, 2025, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/S41598-025-89450-X

Impact of glyphosate (RoundupTM) on the composition and functionality of the gut microbiome

Author(s): Walsh L, Hill C, Ross RP.
Published in: Gut Microbes, 2023, ISSN 1949-0984
Publisher: Taylor and Francis Online
DOI: 10.1080/19490976.2023.2263935

Comparison of fidaxomicin, thuricin CD, vancomycin and nisin highlights the narrow spectrum nature of thuricin CD

Author(s): Walsh L, Lavelle A, O'Connor PM, Hill C, Ross RP.
Published in: Gut Microbes, 2024, ISSN 1949-0984
Publisher: Taylor and Francis Group
DOI: 10.1080/19490976.2024.2342583

Production, composition and nutritional properties of organic milk: A critical review.

Author(s): Linehan K, Patangia DV, Ross RP, Stanton C.
Published in: Foods, 2024, ISSN 2304-8158
Publisher: MDPI
DOI: 10.3390/foods13040550

Impact of bacteriocin-producing strains on bacterial community composition in a simplified human intestinal microbiota

Author(s): Ríos Colombo NS, Perez-Ibarreche M, Draper LA, O’Connor PM, Field D, Ross RP and Hill C.
Published in: Frontiers in Microbiology, 2023, ISSN 1664-302X
Publisher: Frontiers Media
DOI: 10.3389/fmicb.2023.1290697

Winogradskyella bathintestinalis sp. nov., isolated from the intestine of the deep-sea loosejaw dragonfish, Malacosteus niger.

Author(s): Uniacke-Lowe S, Johnson CN, Stanton C, Hill C, Ross P.
Published in: International Journal of Systematic and Evolutionary Microbiology, Issue VOL 73 (10), 2023, ISSN 1466-5034
Publisher: Microbiology Society
DOI: 10.1099/ijsem.0.006135

Bioactivity screening and genomic analysis reveals deep-sea fish microbiome isolates as sources of novel antimicrobials.

Author(s): Uniacke-Lowe S, Collins FWJ, Hill C, Ross RP.
Published in: Marine Drugs, 2023, ISSN 1660-3397
Publisher: MDPI
DOI: 10.3390/md21080444

Somatic cell count as an indicator of subclinical mastitis and increased inflammatory response in asymptomatic lactating women

Author(s): Angelopoulou A, Harris HMB, Warda AK, O’ Shea C-A, Lavelle A, Ryan A, Dempsey E, Stanton C, Ross RP.
Published in: Microbiology Spectrum, 2024, ISSN 2165-0497
Publisher: American Society for Microbiology
DOI: 10.1128/spectrum.04051-23

Synergistic and off-target effects of bacteriocins in a simplified human intestinal microbiome: implications for <i>Clostridioides difficile</i> infection control

Author(s): Natalia S. Ríos Colombo; R. Paul Ross; Colin Hill
Published in: Gut Microbes, 2025, ISSN 2162-402X
Publisher: Taylor & Francis Online
DOI: 10.1080/19490976.2025.2451081

<i>Bacillus safensis</i> APC 4099 has broad-spectrum antimicrobial activity against both bacteria and fungi and produces several antimicrobial peptides, including the novel circular bacteriocin safencin E

Author(s): E. Kamilari, P. M. O'Connor, F. Miceli de Farias, C. N. Johnson, C. Buttimer, A. Deliephan, D. Hill, O. Fursenko, J. Wiese, C. Stanton, C. Hill, R. P. Ross
Published in: Applied and Environmental Microbiology, 2024, ISSN 0099-2240
Publisher: American Society for Microbiology
DOI: 10.1128/aem.01942-24

Early life exposure of infants to benzylpenicillin and gentamicin is associated with a persistent amplification of the gut resistome

Author(s): Patangia DV, Grimaud G, O’ Shea C-A, Ryan CA, Dempsey E, Stanton C, Ross RP.
Published in: Microbiome, 2024, ISSN 2049-2618
Publisher: BMC Part of Springer Nature
DOI: 10.1186/s40168-023-01732-6

Screening canine sources for novel antimicrobials reveals the circular broad-spectrum bacteriocin, caledonicin, produced by Staphylococcus caledonicus.

Author(s): O’Connor M, O’Connor PM, Hourigan D, Murray E, de Farias FM, Field D, Hill C, Ross RP.
Published in: Frontiers in Microbiology, 2024, ISSN 1664-302X
Publisher: Frontiers Media
DOI: 10.3389/fmicb.2024.1470988

Planococcus notacanthi sp. nov., isolated from the skin of a deep-sea snub-nosed spiny eel.

Author(s): Uniacke-Lowe S, Stanton C, Hill C, Ross P
Published in: International Journal of Systemic and Evolutionary Microbiology, 2024, ISSN 1466-5026
Publisher: Microbiology Society
DOI: 10.1099/ijsem.0.006298

Discovery and synthesis of leaderless bacteriocins from the Actinomycetota

Author(s): David Hourigan, Felipe Miceli de Farias, Paula M. O’Connor, Colin Hill, R. Paul Ross
Published in: Journal of Bacteriology, 2024, ISSN 0021-9193
Publisher: American Society for Microbiology
DOI: 10.1128/jb.00298-24

Microbiota and Resistome Analysis of Colostrum and Milk from Dairy Cows Treated with and without Dry Cow Therapies

Author(s): Patangia DV, Grimaud G, Linehan K, Ross RP, Stanton C.
Published in: Antibiotics, 2023, ISSN 2079-6382
Publisher: MDPI
DOI: 10.3390/antibiotics12081315

Genome plasticity shapes the ecology and evolution of Phocaeicola dorei and Phocaeicola vulgatus.

Author(s): Da Silva Morais E, Grimaud GM, Warda A, Stanton C, Ross P.
Published in: Scientific Reports, 2024, ISSN 2045-2322
Publisher: Nature Portfolio
DOI: 10.1038/s41598-024-59148-7

Influence of age, socioeconomic status, and location on the infant gut resistome across populations

Author(s): Patangia DV, Grimaud G, Wang S, Ross RP, Stanton C.
Published in: Gut Microbes, 2023, ISSN 1949-0984
Publisher: Taylor and Francis Group
DOI: 10.1080/19490976.2023.2297837