Objective
Regenerative Medicine aims to restore the composition and organisation of damaged tissues of the human body to regain tissue functionality. When regenerating tissues inside the body (in situ), however, restoration of tissue structural organisation is commonly overlooked. This is particularly problematic for the heart, where functional performance is inseparable from its structurally aligned (= anisotropic) organisation at length scales from the cell to the organ. Two decades of cell-, gene- and material-based therapies to regenerate the damaged heart have mainly targeted the restoration of tissue composition, so far with limited success. I hypothesise that synergistic restoration of tissue anisotropy will radically improve therapy outcomes as it provides the proper environment for cell function, will promote coordinated contraction and halt adverse effects like fibrosis and inflammation. With my team I will test this hypothesis and explore an entirely new concept for restoring cardiac tissue anisotropy remotely using ultrasound. We will create living model systems at the cell and tissue level that recapitulate the increasing heterogeneity of damaged cardiac tissue following cardiac infarction, offer control of cardiac dynamics, and allow manipulation of structural organisation to delineate the interplay between (an)isotropy and cell and tissue functions. By integrating mechanistic understanding from cell and tissue level with multi-scale computational modelling in comparison with an ex vivo living heart model, we will rationally design strategies to mechanically RE-ALIGN diseased, disorganised cardiac tissue at the organ level and evaluate to what extend this can be achieved using ultrasound. By focusing on regenerating structure-function properties in situ, this multidisciplinary, technology-driven project provides unique insights and novel tools that may open up new therapeutic concepts for Regenerative Medicine in general and Cardiac Regeneration in particular.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC - HORIZON ERC Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2021-ADG
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
5612 AE Eindhoven
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.