Description du projet
Dépister la dysplasie de la hanche chez l’enfant avant que la fenêtre de traitement ne se referme
La hanche est la plus grande articulation portante du corps. La dysplasie de la hanche, une malformation caractérisée par une cavité trop peu profonde pour supporter la tête, touche chaque année des milliers d’enfants et d’adultes. Elle peut conduire à l’arthrose si elle n’est pas traitée avant l’âge de 13 ans environ, lorsque les plaques de croissance de la hanche se referment. Si le dépistage chez le nourrisson est important, la dysplasie de la hanche peut toutefois se développer à la fin de l’enfance et à l’adolescence. Financé par le Conseil européen de la recherche, le projet HIPSTAR suivra 8 000 enfants depuis l’utérus jusqu'à l’âge de 18 ans, en élaborant un modèle de développement de la forme de la hanche et en révélant les signes précurseurs d’une croissance dysplasique. Un modèle informatique examinera les éventuelles mesures réparatrices.
Objectif
With 40 million patients in Europe, osteoarthritis (OA) is the most common chronic and disabling disease. OA is incurable, and symptomatic treatments have limited effect. Therefore, prevention by identifying and targeting asymptomatic persons that develop a clear OA risk factor is sorely needed. Hip dysplasia is the strongest risk factor for hip OA. Hip dysplasia is a condition of mechanical instability of the hip caused by insufficient coverage of the femoral head (ball) by a shallow or obliquely oriented acetabulum (socket). This results in high cartilage stress, and subsequent hip OA. In Europe we screen for developmental hip dysplasia in infants (prevalence 2%), enabling early treatment. However, we discovered that hip dysplasia can (further) develop during skeletal maturation and thus remains unrecognized. In 1100 Dutch 9-year-old children we found a 6% and 26% prevalence of marked and mild hip dysplasia, respectively. Hip dysplasia can be influenced until the stage where hip growth plates close at about age 13. I propose a novel research program (HIPSTAR) where I will uniquely unravel the mechanisms behind late childhood hip dysplasia in order to pave the way for devising preventive measures that reduce the prevalence of adult hip dysplasia and, thus, hip OA. In a birth cohort of 8000 children (followed from foetal life until adulthood), I will first uniquely built a 5D growth model on how hip shape develops over time from age 2-18 years. I will gain novel knowledge regarding causal factors of dysplastic growth, and whether there are various phenotypes that have different underlying mechanisms. I also will study how and when dysplastic growth will already impact on the integrity of the young adult joint, and discover very early signs of joint aberration leading to OA. Finally, in a computational model, I will test the influence of loading factors on dysplastic growth mechanistically, and provide detailed information regarding the potential remedial options.
Champ scientifique
- natural sciencesbiological sciencesdevelopmental biology
- medical and health sciencesclinical medicineobstetricsfetal medicine
- medical and health sciencesclinical medicineorthopaedics
- natural sciencescomputer and information sciencescomputational sciencemultiphysics
- natural sciencesmathematicsapplied mathematicsmathematical model
Programme(s)
- HORIZON.1.1 - European Research Council (ERC) Main Programme
Thème(s)
Régime de financement
ERC - Support for frontier research (ERC)Institution d’accueil
3015 GD Rotterdam
Pays-Bas