Local and systemic mechanisms for metabolic inflammation chronicity

Informations projet

LOSYSINCHRON

N° de convention de subvention: 101055377

DOI

10.3030/101055377

Date de signature de la CE 16 Juin 2022

Date de début 1 Mars 2023

Date de fin 29 Février 2028

Financé au titre de

• European Research Council (ERC)

Coût total

€ 2 493 275,00

Contribution de l’UE

€ 2 493 275,00

Coordonné par

TECHNISCHE UNIVERSITAET DRESDEN
Germany

Periodic Reporting for period 1 - LOSYSINCHRON (Local and systemic mechanisms for metabolic inflammation chronicity)

Période du rapport: 2023-03-01 au 2025-08-31

Résumé du contexte et des objectifs généraux du projet

Chronic inflammation is considered a major mechanism underlying the pathogenesis and progression of several diseases, especially non-communicable diseases, such as cardiometabolic diseases or inflammatory pathologies. Such non-communicable diseases lead to major morbidity and mortality and are therefore enormous problems in our society. Moreover, chronic inflammation is considered a common denominator for the emergence of different comorbidities; the term comorbidities defines the simultaneous presence of two or more conditions. The prevalence of non-communicable diseases is increasing in our aging society. In this context, the term “inflammaging” describes the increased inflammatory burden that comes along with high age. In obesity, chronic inflammation of the adipose tissue and liver contributes to the metabolic syndrome and insulin resistance as well as to related metabolic-inflammatory pathologies, such as non-alcoholic fatty liver disease (NAFLD) that was recently renamed to metabolic dysfunction-associated steatotic liver disease (MASLD). Moreover, metabolic organ inflammation can also trigger systemic inflammation that could potentially promote the development of further inflammatory comorbidities and enhance disease burden.
But how does inflammation become chronic? Whereas acute inflammation is typically limited and readily cleared, chronic inflammation persists due to multiple reasons and mechanisms that are poorly understood. Therefore, our project addresses mechanisms of inflammation chronicity with a particular focus on metabolic inflammation chronicity. The objectives of the project are to understand mechanisms contributing to inflammation chronicity at different levels (at the local tissue level and at the systemic level). Providing new insights into the processes underlying chronic inflammation, relevant for obesity-related metabolic inflammation and inflammatory diseases, is of fundamental importance towards a better understanding of disease pathogenesis and emergence of inflammatory comorbidities and for being able to identify novel preventive and therapeutic strategies for inflammatory pathologies in the future.

Travail effectué depuis le début du projet jusqu’à la fin de la période considérée dans le rapport et principaux résultats atteints jusqu’à présent

Our project focuses on a thorough, innovative and integrated approach to mechanistically understand chronicity of inflammation, including metabolic inflammation. To this end, we focus on: (a) Local inflammatory mechanisms at the tissue level, especially in the adipose tissue and liver, in the context of obesity-related metabolic-inflammatory disease, such as metabolic syndrome and MASLD, and (b) Systemic mechanisms involving induction of maladaptive trained innate immunity (TII) that could also contribute to inflammatory comorbidities.

We use models of inflammation and inflammatory disease; we also use models of diet-induced obesity and diet-induced liver disease that allow us to study dysmetabolism-related inflammation of metabolic organs (adipose tissue and liver) and systemic inflammation.

(I) Local mechanisms: In chronic metabolic inflammation, there is an imbalance between activation of inflammatory cells, especially myeloid cells, and anti-inflammatory processes contributing to termination of inflammation. Metabolic signals in the obese adipose tissue and liver microenvironment shape the function of multiple cells, including immune cells, as well as non-immune tissue cells, in part via alterations in their cellular metabolism. We study metabolic pathways and their role in inflammatory cell activation and regulation of inflammation, including metabolic organ inflammation.

(II) Systemic mechanisms via maladaptive TII: Maladaptive TII involves long-term adaptations of innate immune cells that acquire higher capacity for inflammatory responses. Maladaptive TII may be initiated at the level of hematopoietic progenitors of innate immune cells in the bone marrow, via sustained epigenetic alterations, thereby potentially driving enhanced production of myeloid cells with stronger inflammatory capacity, hence, further reinforcing a feed-forward loop of perpetual inflammation that drives systemic inflammation chronicity. We pursue the hypothesis that maladaptive TII facilitates chronicity of inflammation, including metabolic inflammation, as well as promotes emergence of inflammatory comorbidities. In this context, we have also found that clonal hematopoiesis, associated with mutations in the epigenetic regulator DNA methyltransferase 3A, triggers inflammation and higher inflammatory bone loss, in a manner that has some similarities to maladaptive bone marrow-mediated TII. Moreover, we study new facets of maladaptive TII in the context of inflammation; such aspects are studied also under conditions of diet-induced obesity and metabolic dysregulation in order to understand how metabolic dysfunction-induced maladaptive TII could drive inflammation and enhanced severity of inflammatory comorbidities.

Progrès au-delà de l’état des connaissances et impact potentiel prévu (y compris l’impact socio-économique et les conséquences sociétales plus larges du projet jusqu’à présent)

We believe that, upon completion, our project will provide findings that are beyond the state of the art and will improve understanding of local and systemic mechanisms contributing to inflammation and its chronicity.