HLA-homozygous iPSC-cardiomyocytE Aggregate manufacturing technoLogies for allogenic cell therapy to the heart

Project Information

HEAL

Grant agreement ID: 101056712

DOI

10.3030/101056712

EC signature date 23 May 2022

Start date 1 September 2022

End date 28 February 2027

Funded under

• Health

Total cost

€ 5 824 074,75

EU contribution

€ 5 824 074,00

Coordinated by

MEDIZINISCHE HOCHSCHULE HANNOVER
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Websites, patent fillings, videos etc. (1)

Launch of project website

D6.2Launch of project website

Publications

Peer reviewed articles (21)

Abstract 23 HLA-Homozygous iPSC from Cord Blood for the Generation of Cardiomyocytes for Allogeneic Cell Therapy to the Heart

Author(s): Fabienne Becker, Stefanie Liedtke, Boris Greber, Nils Kriedemann, Ulrich Martin, Robert Zweigerdt, Gesine Kögler
Published in: Stem Cells Translational Medicine, 2023, ISSN 2157-6564
Publisher: STEM CELLS Translatinal Medicine
DOI: 10.1093/stcltm/szad047.024

DNA-binding affinity and specificity determine the phenotypic diversity in BCL11B-related disorders

Author(s): Ivana Lessel, Anja Baresic, Ivan K. Chinn, Jonathan May, Anu Goenka, Kate E. Chandler, Jennifer E. Posey, Alexandra Afenjar, Luisa Averdunk, Maria Francesca Bedeschi, Thomas Besnard, Rae Brager, Lauren Brick, Melanie Brugger, Theresa Brunet, Susan Byrne, Oscar de la Calle-Martín, Valeria Capra, Paul Cardenas, Céline Chappé, Hey J. Chong, Benjamin Cogne, Erin Conboy, Heidi Cope, Thomas Courtin, Wallid Deb, Robertino Dilena, Christèle Dubourg, Magdeldin Elgizouli, Erica Fernandes, Kristi K. Fitzgerald, Silvana Gangi, Jaya K. George-Abraham, Muge Gucsavas-Calikoglu, Tobias B. Haack, Medard Hadonou, Britta Hanker, Irina Hüning, Maria Iascone, Bertrand Isidor, Irma Järvelä, Jay J. Jin, Alexander A.L. Jorge, Dragana Josifova, Ruta Kalinauskiene, Erik-Jan Kamsteeg, Boris Keren, Elena Kessler, Heike Kölbel, Mariya Kozenko, Christian Kubisch, Alma Kuechler, Suzanne M. Leal, Juha Leppälä, Sharon M. Luu, Gholson J. Lyon, Suneeta Madan-Khetarpal, Margherita Mancardi, Elaine Marchi, Lakshmi Mehta, Beatriz Menendez, Chantal F. Morel, Sue Moyer Harasink, Dayna-Lynn Nevay, Vincenzo Nigro, Sylvie Odent, Renske Oegema, John Pappas, Matthew T. Pastore, Yezmin Perilla-Young, Konrad Platzer, Nina Powell-Hamilton, Rachel Rabin, Aisha Rekab, Raissa C. Rezende, Leema Robert, Ferruccio Romano, Marcello Scala, Karin Poths, Isabelle Schrauwen, Jessica Sebastian, John Short, Richard Sidlow, Jennifer Sullivan, Katalin Szakszon, Queenie K.G. Tan, Matias Wagner, Dagmar Wieczorek, Bo Yuan, Nicole Maeding, Dirk Strunk, Amber Begtrup, Siddharth Banka, James R. Lupski, Eva Tolosa, Davor Lessel
Published in: The American Journal of Human Genetics, 2025, ISSN 0002-9297
Publisher: Elsevier BV
DOI: 10.1016/j.ajhg.2024.12.012

Abstract 12: Cord Blood Banking, Technical and Clinical grade GMP- Development of Advanced Therapy Products as HLA-Homozygous iPSC-derived Cardiomyocytes

Author(s): Fabienne Becker, Rigveda Bhave, Soraia Martins, Melanie Hühne, Boris Greber, Gesine Kogler
Published in: Stem Cells Translational Medicine, Issue 13, 2024, ISSN 2157-6564
Publisher: Oxford University Press (OUP)
DOI: 10.1093/STCLTM/SZAE062.012

Standardized production of hPSC-derived cardiomyocyte aggregates in stirred spinner flasks

Author(s): Nils Kriedemann, Wiebke Triebert, Jana Teske Mira Mertens, Annika Franke, Kevin Ullmann, Felix Manstein, Lika Drakhlis, Alexandra Haase, Caroline Halloin, Ulrich Martin, Robert Zweigerdt
Published in: Nature Protocols, 2024, ISSN 1750-2799
Publisher: Nature Publishing Group
DOI: 10.1038/s41596-024-00976-2

Journal of Cardiovascular Translational Research

Author(s): Maaike Wulfse; Mats T. Vervoorn; Jantijn J. G. J. Amelink; Elisa M. Ballan; Saskia C. A. de Jager; Joost P. G. Sluijter; Pieter A. Doevendans; Peter-Paul M. Zwetsloot; Niels P. Van der Kaaij
Published in: Journal of Cardiovascular Translational Research, 2024, ISSN 1937-5387
Publisher: Springer Pub. Co.,
DOI: 10.1007/S12265-024-10563-1

Exploring stem cell frontiers: definitions, challenges, and perspectives for regenerative medicine

Author(s): Miriana Dardano; Tamina Lebek; Ingrid H. C. Tsang
Published in: Biology Open, 2024, ISSN 2079-7737
Publisher: Biology
DOI: 10.1242/BIO.060245

Cancer Biology and Therapy

Author(s): Celina Ablinger; Daniel Neureiter; Theresa Mähr; Christian Mayr; Tobias Kiesslich; Nicole Maeding; Irina Valenta; Maximilian Ardelt; Fabian Wilhelm; Elen Neureiter; Markus Ritter; Johanna Pachmayr; Petra Huber-Cantonati
Published in: Cancer Biology and Therapy, 2024, ISSN 1538-4047
Publisher: Landes Bioscience
DOI: 10.1080/15384047.2024.2439057

Large-scale analysis of loss of chromosome Y in human pluripotent stem cells: Implications for Turner syndrome and ribosomopathies

Author(s): Roni Sarel-Gallily, Keith M. Gunapala, Nissim Benvenisty
Published in: Stem Cell Reports, Issue 20, 2025, ISSN 2213-6711
Publisher: Elsevier BV
DOI: 10.1016/J.STEMCR.2025.102471

DMM Disease Models and Mechanisms

Author(s): Lika Drakhlis; Robert Zweigerdt
Published in: Disease Models & Mechanisms, 2023, ISSN 1754-8403
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/DMM.049961

Hydrogel microsphere stem cell encapsulation enhances cardiomyocyte differentiation and functionality in scalable suspension system

Author(s): Mohammadjafar Hashemi; Ferdous B. Finklea; Hanna Hammons; Yuan Tian; Nathan Young; Emma Kim; Caroline Halloin; Wiebke Triebert; Robert Zweigerdt; Amit Kumar Mitra; Elizabeth A. Lipke
Published in: Bioactive Materials, 2025, ISSN 2452-199X
Publisher: Ke Ai Publishing
DOI: 10.1016/J.BIOACTMAT.2024.08.043

High prevalence of acquired cancer-related mutations in 146 human pluripotent stem cell lines and their differentiated derivatives

Author(s): Lezmi, E.; Jung, J.; Benvenisty, N.
Published in: Nature Biotechnology, 2024, ISSN 1546-1696
Publisher: Springer Nature
DOI: 10.1038/s41587-023-02090-2

Participation in SoHO and ATMP public consultations: a fragmented institutional landscape

Author(s): Morrison, Michael; Brunel, Valentin; Mahalatchimy, Aurélie
Published in: Humanities and Social Sciences Communications, 2025, ISSN 2662-9992
Publisher: Springer Nature
DOI: 10.1057/S41599-025-04552-1

Blood-generating heart-forming organoids recapitulate co-development of the human haematopoietic system and the embryonic heart

Author(s): Miriana Dardano; Felix Kleemiß; Maike Kosanke; Dorina Lang; Liam Wilson; Annika Franke; Jana Teske; Akshatha Shivaraj; Jeanne de la Roche; Martin Fischer; Lucas Lange; Axel Schambach; Lika Drakhlis; Robert Zweigerdt
Published in: Nature Cell Biology, 2024, ISSN 1476-4679
Publisher: Nature Cell Biology
DOI: 10.1038/S41556-024-01526-4

Stem Cell Research and Therapy

Author(s): Nils Kriedemann; Felix Manstein; Carlos A. Hernandez-Bautista; Kevin Ullmann; Wiebke Triebert; Annika Franke; Mira Mertens; Inês Carvalheira Arnaut Pombeiro Stein; Andreas Leffler; Merlin Witte; Tamari Askurava; Veronika Fricke; Ina Gruh; Birgit Piep; Kathrin Kowalski; Theresia Kraft; Robert Zweigerdt
Published in: Stem Cell Research & Therapy, 2024, ISSN 1757-6512
Publisher: Stem Cell Research and Therapy
DOI: 10.1186/S13287-024-03826-W

EpiTyping: analysis of epigenetic aberrations in parental imprinting and X-chromosome inactivation using RNA-seq

Author(s): Sarel-Gallily,R.; Keshet, G.; Benvenisty, N.
Published in: Nature Protocols, Issue 18, 2023, ISSN 1754-2189
Publisher: Nature Publishing Group
DOI: 10.1038/s41596-023-00898-5

Stem cells translational medicine

Author(s): Becker, Fabienne; Bhave, Rigveda; Martins, Soraia; Hühne, Melanie; Greber, Boris; Kogler, Gesine
Published in: Stem Cells Translational Medicine, 2024, ISSN 2157-6564
Publisher: AlphaMed Press
DOI: 10.1093/STCLTM/SZAE062.012

Stem Cell Reports

Author(s): Kinreich, Shay; Bialer-Tsypin, Anna; Viner-Breuer, Ruth; Keshet, Gal; Suhler, Roni; Lim, Patrick Siang Lin; Golan-Lev, Tamar; Yanuka, Ofra; Turjeman, Adi; Ram, Oren; Meshorer, Eran; Egli, Dieter; Yilmaz, Atilgan; Benvenisty, Nissim
Published in: Stem Cell Reports, 2024, ISSN 2213-6711
Publisher: Stem Cell Reports
DOI: 10.1016/J.STEMCR.2024.09.009

Human Cardiac Microtissues Display Improved Engraftment and Survival in a Porcine Model of Myocardial Infarction

Author(s): Evelyne Demkes; Aina Cervera-Barea; Patricia Ebner-Peking; Martin Wolf; Sarah Hochmann; Amy S. Scheren; Mayke Bijsterveld; C. Marlies van Oostveen; Marlijn Jansen; Joyce Visser; Wiebke Triebert; Caroline Halloin; Johannes G. G. Dobbe; Judith de Vos; Melanie Schürz; Joachim Danmayr; Maurice C. G. Aalders; Gerard J. J. Boink; Klaus Neef; Dirk Strunk; Robert Zweigerdt; Saskia C. A. de Jager; Joost P. G. Sluijter
Published in: Journal of Cardiovascular Translational Research, 2025, ISSN 1476-4687
Publisher: Springer Nature
DOI: 10.1007/S12265-025-10596-0

Stem Cell Research and Therapy

Author(s): Kevin Ullmann; Felix Manstein; Wiebke Triebert; Nils Kriedemann; Annika Franke; Jana Teske; Mira Mertens; Victoria Lupanow; Gudrun Göhring; Alexandra Haase; Ulrich Martin; Robert Zweigerdt
Published in: Stem Cell Research and Therapy, 2024, ISSN 1757-6512
Publisher: BioMed Central
DOI: 10.1186/S13287-024-03699-Z

Advances in extracellular vesicle research over the past decade: Source and isolation method are connected with cargo and function

Author(s): Rodolphe Poupardin, Martin Wolf, Nicole Maeding, Liliia Paniushkina, Sven Geissler, Paolo Bergese, Kenneth W Witwer, Katharina Schallmoser, Gregor Fuhrmann, Dirk Strunk
Published in: Advanced Healthcare Materials, 2024, ISSN 2192-2640
Publisher: Wiley
DOI: 10.1002/adhm.202303941

Cell therapy with human iPSC-derived cardiomyocyte aggregates leads to efficient engraftment and functional recovery after myocardial infarction in non-human

Author(s): Ina Gruh, Andreas Martens, Serghei Cebotari, Annette Schrod, Alexandra Haase, Caroline Halloin, Wiebke Triebert, Tobias Goecke, Morsi Arar, Klaus Hoeffler, Paul Frank, Karen Lampe, Amir Moussavi, Veronika Fricke, Nils Kriedemann, Monika Szepes, Kerstin Mä
Published in: bioRxiv, 2024, ISSN 1231-5737
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2023.12.31.573775

Thesis and dissertations (1)

Physical and physiological control of human pluripotent stem cells culture

Author(s): Ullmann, Kevin
Published in: 2023
Publisher: Medizinische Hochschule
DOI: 10.26068/MHHRPM/20230714-000

Other (1)

Journal of General Physiology

Author(s): Felix Osten; Natalie Weber; Meike Wendland; Tim Holler; Birgit Piep; Simon Kröhn; Jana Teske; Alea K. Bodenschatz; Santoshi Biswanath Devadas; Kaja S. Menge; Shambhabi Chatterjee; Kristin Schwanke; Maike Kosanke; Judith Montag; Thomas Thum; Robert Zweigerdt; Theresia Kraft; Bogdan Iorga; Joachim D. Meissner
Published in: Journal of General Physiology, 2023, ISSN 0022-1295
Publisher: Rockefeller University Press
DOI: 10.1085/JGP.202313377