HLA-homozygous iPSC-cardiomyocytE Aggregate manufacturing technoLogies for allogenic cell therapy to the heart

Informazioni relative al progetto

HEAL

ID dell’accordo di sovvenzione: 101056712

DOI

10.3030/101056712

Data della firma CE 23 Maggio 2022

Data di avvio 1 Settembre 2022

Data di completamento 28 Febbraio 2027

Finanziato da

• Health

Costo totale

€ 5 824 074,75

Contributo UE

€ 5 824 074,00

Coordinato da

MEDIZINISCHE HOCHSCHULE HANNOVER
Germany

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Websites, patent fillings, videos etc. (1)

Launch of project website

D6.2Launch of project website

Pubblicazioni

Peer reviewed articles (21)

Abstract 23 HLA-Homozygous iPSC from Cord Blood for the Generation of Cardiomyocytes for Allogeneic Cell Therapy to the Heart

Autori: Fabienne Becker, Stefanie Liedtke, Boris Greber, Nils Kriedemann, Ulrich Martin, Robert Zweigerdt, Gesine Kögler
Pubblicato in: Stem Cells Translational Medicine, 2023, ISSN 2157-6564
Editore: STEM CELLS Translatinal Medicine
DOI: 10.1093/stcltm/szad047.024

DNA-binding affinity and specificity determine the phenotypic diversity in BCL11B-related disorders

Autori: Ivana Lessel, Anja Baresic, Ivan K. Chinn, Jonathan May, Anu Goenka, Kate E. Chandler, Jennifer E. Posey, Alexandra Afenjar, Luisa Averdunk, Maria Francesca Bedeschi, Thomas Besnard, Rae Brager, Lauren Brick, Melanie Brugger, Theresa Brunet, Susan Byrne, Oscar de la Calle-Martín, Valeria Capra, Paul Cardenas, Céline Chappé, Hey J. Chong, Benjamin Cogne, Erin Conboy, Heidi Cope, Thomas Courtin, Wallid Deb, Robertino Dilena, Christèle Dubourg, Magdeldin Elgizouli, Erica Fernandes, Kristi K. Fitzgerald, Silvana Gangi, Jaya K. George-Abraham, Muge Gucsavas-Calikoglu, Tobias B. Haack, Medard Hadonou, Britta Hanker, Irina Hüning, Maria Iascone, Bertrand Isidor, Irma Järvelä, Jay J. Jin, Alexander A.L. Jorge, Dragana Josifova, Ruta Kalinauskiene, Erik-Jan Kamsteeg, Boris Keren, Elena Kessler, Heike Kölbel, Mariya Kozenko, Christian Kubisch, Alma Kuechler, Suzanne M. Leal, Juha Leppälä, Sharon M. Luu, Gholson J. Lyon, Suneeta Madan-Khetarpal, Margherita Mancardi, Elaine Marchi, Lakshmi Mehta, Beatriz Menendez, Chantal F. Morel, Sue Moyer Harasink, Dayna-Lynn Nevay, Vincenzo Nigro, Sylvie Odent, Renske Oegema, John Pappas, Matthew T. Pastore, Yezmin Perilla-Young, Konrad Platzer, Nina Powell-Hamilton, Rachel Rabin, Aisha Rekab, Raissa C. Rezende, Leema Robert, Ferruccio Romano, Marcello Scala, Karin Poths, Isabelle Schrauwen, Jessica Sebastian, John Short, Richard Sidlow, Jennifer Sullivan, Katalin Szakszon, Queenie K.G. Tan, Matias Wagner, Dagmar Wieczorek, Bo Yuan, Nicole Maeding, Dirk Strunk, Amber Begtrup, Siddharth Banka, James R. Lupski, Eva Tolosa, Davor Lessel
Pubblicato in: The American Journal of Human Genetics, 2025, ISSN 0002-9297
Editore: Elsevier BV
DOI: 10.1016/j.ajhg.2024.12.012

Abstract 12: Cord Blood Banking, Technical and Clinical grade GMP- Development of Advanced Therapy Products as HLA-Homozygous iPSC-derived Cardiomyocytes

Autori: Fabienne Becker, Rigveda Bhave, Soraia Martins, Melanie Hühne, Boris Greber, Gesine Kogler
Pubblicato in: Stem Cells Translational Medicine, Numero 13, 2024, ISSN 2157-6564
Editore: Oxford University Press (OUP)
DOI: 10.1093/STCLTM/SZAE062.012

Standardized production of hPSC-derived cardiomyocyte aggregates in stirred spinner flasks

Autori: Nils Kriedemann, Wiebke Triebert, Jana Teske Mira Mertens, Annika Franke, Kevin Ullmann, Felix Manstein, Lika Drakhlis, Alexandra Haase, Caroline Halloin, Ulrich Martin, Robert Zweigerdt
Pubblicato in: Nature Protocols, 2024, ISSN 1750-2799
Editore: Nature Publishing Group
DOI: 10.1038/s41596-024-00976-2

Journal of Cardiovascular Translational Research

Autori: Maaike Wulfse; Mats T. Vervoorn; Jantijn J. G. J. Amelink; Elisa M. Ballan; Saskia C. A. de Jager; Joost P. G. Sluijter; Pieter A. Doevendans; Peter-Paul M. Zwetsloot; Niels P. Van der Kaaij
Pubblicato in: Journal of Cardiovascular Translational Research, 2024, ISSN 1937-5387
Editore: Springer Pub. Co.,
DOI: 10.1007/S12265-024-10563-1

Exploring stem cell frontiers: definitions, challenges, and perspectives for regenerative medicine

Autori: Miriana Dardano; Tamina Lebek; Ingrid H. C. Tsang
Pubblicato in: Biology Open, 2024, ISSN 2079-7737
Editore: Biology
DOI: 10.1242/BIO.060245

Cancer Biology and Therapy

Autori: Celina Ablinger; Daniel Neureiter; Theresa Mähr; Christian Mayr; Tobias Kiesslich; Nicole Maeding; Irina Valenta; Maximilian Ardelt; Fabian Wilhelm; Elen Neureiter; Markus Ritter; Johanna Pachmayr; Petra Huber-Cantonati
Pubblicato in: Cancer Biology and Therapy, 2024, ISSN 1538-4047
Editore: Landes Bioscience
DOI: 10.1080/15384047.2024.2439057

Large-scale analysis of loss of chromosome Y in human pluripotent stem cells: Implications for Turner syndrome and ribosomopathies

Autori: Roni Sarel-Gallily, Keith M. Gunapala, Nissim Benvenisty
Pubblicato in: Stem Cell Reports, Numero 20, 2025, ISSN 2213-6711
Editore: Elsevier BV
DOI: 10.1016/J.STEMCR.2025.102471

DMM Disease Models and Mechanisms

Autori: Lika Drakhlis; Robert Zweigerdt
Pubblicato in: Disease Models & Mechanisms, 2023, ISSN 1754-8403
Editore: The Company of Biologists Ltd.
DOI: 10.1242/DMM.049961

Hydrogel microsphere stem cell encapsulation enhances cardiomyocyte differentiation and functionality in scalable suspension system

Autori: Mohammadjafar Hashemi; Ferdous B. Finklea; Hanna Hammons; Yuan Tian; Nathan Young; Emma Kim; Caroline Halloin; Wiebke Triebert; Robert Zweigerdt; Amit Kumar Mitra; Elizabeth A. Lipke
Pubblicato in: Bioactive Materials, 2025, ISSN 2452-199X
Editore: Ke Ai Publishing
DOI: 10.1016/J.BIOACTMAT.2024.08.043

High prevalence of acquired cancer-related mutations in 146 human pluripotent stem cell lines and their differentiated derivatives

Autori: Lezmi, E.; Jung, J.; Benvenisty, N.
Pubblicato in: Nature Biotechnology, 2024, ISSN 1546-1696
Editore: Springer Nature
DOI: 10.1038/s41587-023-02090-2

Participation in SoHO and ATMP public consultations: a fragmented institutional landscape

Autori: Morrison, Michael; Brunel, Valentin; Mahalatchimy, Aurélie
Pubblicato in: Humanities and Social Sciences Communications, 2025, ISSN 2662-9992
Editore: Springer Nature
DOI: 10.1057/S41599-025-04552-1

Blood-generating heart-forming organoids recapitulate co-development of the human haematopoietic system and the embryonic heart

Autori: Miriana Dardano; Felix Kleemiß; Maike Kosanke; Dorina Lang; Liam Wilson; Annika Franke; Jana Teske; Akshatha Shivaraj; Jeanne de la Roche; Martin Fischer; Lucas Lange; Axel Schambach; Lika Drakhlis; Robert Zweigerdt
Pubblicato in: Nature Cell Biology, 2024, ISSN 1476-4679
Editore: Nature Cell Biology
DOI: 10.1038/S41556-024-01526-4

Stem Cell Research and Therapy

Autori: Nils Kriedemann; Felix Manstein; Carlos A. Hernandez-Bautista; Kevin Ullmann; Wiebke Triebert; Annika Franke; Mira Mertens; Inês Carvalheira Arnaut Pombeiro Stein; Andreas Leffler; Merlin Witte; Tamari Askurava; Veronika Fricke; Ina Gruh; Birgit Piep; Kathrin Kowalski; Theresia Kraft; Robert Zweigerdt
Pubblicato in: Stem Cell Research & Therapy, 2024, ISSN 1757-6512
Editore: Stem Cell Research and Therapy
DOI: 10.1186/S13287-024-03826-W

EpiTyping: analysis of epigenetic aberrations in parental imprinting and X-chromosome inactivation using RNA-seq

Autori: Sarel-Gallily,R.; Keshet, G.; Benvenisty, N.
Pubblicato in: Nature Protocols, Numero 18, 2023, ISSN 1754-2189
Editore: Nature Publishing Group
DOI: 10.1038/s41596-023-00898-5

Stem cells translational medicine

Autori: Becker, Fabienne; Bhave, Rigveda; Martins, Soraia; Hühne, Melanie; Greber, Boris; Kogler, Gesine
Pubblicato in: Stem Cells Translational Medicine, 2024, ISSN 2157-6564
Editore: AlphaMed Press
DOI: 10.1093/STCLTM/SZAE062.012

Stem Cell Reports

Autori: Kinreich, Shay; Bialer-Tsypin, Anna; Viner-Breuer, Ruth; Keshet, Gal; Suhler, Roni; Lim, Patrick Siang Lin; Golan-Lev, Tamar; Yanuka, Ofra; Turjeman, Adi; Ram, Oren; Meshorer, Eran; Egli, Dieter; Yilmaz, Atilgan; Benvenisty, Nissim
Pubblicato in: Stem Cell Reports, 2024, ISSN 2213-6711
Editore: Stem Cell Reports
DOI: 10.1016/J.STEMCR.2024.09.009

Human Cardiac Microtissues Display Improved Engraftment and Survival in a Porcine Model of Myocardial Infarction

Autori: Evelyne Demkes; Aina Cervera-Barea; Patricia Ebner-Peking; Martin Wolf; Sarah Hochmann; Amy S. Scheren; Mayke Bijsterveld; C. Marlies van Oostveen; Marlijn Jansen; Joyce Visser; Wiebke Triebert; Caroline Halloin; Johannes G. G. Dobbe; Judith de Vos; Melanie Schürz; Joachim Danmayr; Maurice C. G. Aalders; Gerard J. J. Boink; Klaus Neef; Dirk Strunk; Robert Zweigerdt; Saskia C. A. de Jager; Joost P. G. Sluijter
Pubblicato in: Journal of Cardiovascular Translational Research, 2025, ISSN 1476-4687
Editore: Springer Nature
DOI: 10.1007/S12265-025-10596-0

Stem Cell Research and Therapy

Autori: Kevin Ullmann; Felix Manstein; Wiebke Triebert; Nils Kriedemann; Annika Franke; Jana Teske; Mira Mertens; Victoria Lupanow; Gudrun Göhring; Alexandra Haase; Ulrich Martin; Robert Zweigerdt
Pubblicato in: Stem Cell Research and Therapy, 2024, ISSN 1757-6512
Editore: BioMed Central
DOI: 10.1186/S13287-024-03699-Z

Advances in extracellular vesicle research over the past decade: Source and isolation method are connected with cargo and function

Autori: Rodolphe Poupardin, Martin Wolf, Nicole Maeding, Liliia Paniushkina, Sven Geissler, Paolo Bergese, Kenneth W Witwer, Katharina Schallmoser, Gregor Fuhrmann, Dirk Strunk
Pubblicato in: Advanced Healthcare Materials, 2024, ISSN 2192-2640
Editore: Wiley
DOI: 10.1002/adhm.202303941

Cell therapy with human iPSC-derived cardiomyocyte aggregates leads to efficient engraftment and functional recovery after myocardial infarction in non-human

Autori: Ina Gruh, Andreas Martens, Serghei Cebotari, Annette Schrod, Alexandra Haase, Caroline Halloin, Wiebke Triebert, Tobias Goecke, Morsi Arar, Klaus Hoeffler, Paul Frank, Karen Lampe, Amir Moussavi, Veronika Fricke, Nils Kriedemann, Monika Szepes, Kerstin Mä
Pubblicato in: bioRxiv, 2024, ISSN 1231-5737
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/2023.12.31.573775

Thesis and dissertations (1)

Physical and physiological control of human pluripotent stem cells culture

Autori: Ullmann, Kevin
Pubblicato in: 2023
Editore: Medizinische Hochschule
DOI: 10.26068/MHHRPM/20230714-000

Other (1)

Journal of General Physiology

Autori: Felix Osten; Natalie Weber; Meike Wendland; Tim Holler; Birgit Piep; Simon Kröhn; Jana Teske; Alea K. Bodenschatz; Santoshi Biswanath Devadas; Kaja S. Menge; Shambhabi Chatterjee; Kristin Schwanke; Maike Kosanke; Judith Montag; Thomas Thum; Robert Zweigerdt; Theresia Kraft; Bogdan Iorga; Joachim D. Meissner
Pubblicato in: Journal of General Physiology, 2023, ISSN 0022-1295
Editore: Rockefeller University Press
DOI: 10.1085/JGP.202313377