MERGING SUSTAINABLE AND DIGITAL CHEMICAL TECHNOLOGIES FOR THE DEVELOPMENT OF GREENER-BY-DESIGN PHARMACEUTICALS

Project Information

SusPharma

Grant agreement ID: 101057430

DOI

10.3030/101057430

EC signature date 23 May 2022

Start date 1 September 2022

End date 31 August 2026

Funded under

• Health

Total cost

€ 6 205 435,00

EU contribution

€ 6 205 434,50

Coordinated by

UNIVERSITA DEGLI STUDI DI BARI ALDO MORO
Italy

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Websites, patent fillings, videos etc. (2)

Data Management plan.
Website, Twitter account and communication material.

Publications

Peer reviewed articles (46)

Nature Communications

Author(s): Gianvito Vilé; Miguel M. de Vries Ibáñez; Luis A. Cipriano; Giovanni Di Liberto
Published in: Nature Communications, 2025, ISSN 2041-1723
Publisher: Nature Portfolio
DOI: 10.1038/S41467-025-61639-8

Nanostructured Carbon Nitride for Continuous-Flow Trifluoromethylation of (Hetero)arenes

Author(s): Alessandra Sivo, Vincenzo Ruta, Vittoria Granata, Oleksandr Savateev, Mark A. Bajada, and Gianvito Vilé
Published in: ACS Sustainable Chemistry & Engineering, 2023, ISSN 2168-0485
Publisher: American Chemical Society
DOI: 10.1021/ACSSUSCHEMENG.3C00176

Continuous Flow Decarboxylative Monofluoroalkylation Enabled by Photoredox Catalysis

Author(s): Pasca, Francesco; Gelato, Yuri; Andresini, Michael; Serbetci, Defne; Natho, Philipp; Romanazzi, Giuseppe; Degennaro, Leonardo; Colella, Marco; Luisi, Renzo
Published in: JACS Au, 2025, ISSN 2691-3704
Publisher: American Chemical Society
DOI: 10.1021/JACSAU.4C00902

Resolving the Nanostructure of Carbon Nitride‐Supported Single‐Atom Catalysts

Author(s): Nicolò Allasia, Shuai Xu, Sadaf Fatima Jafri, Elisa Borfecchia, Luis A. Cipriano, Giancarlo Terraneo, Sergio Tosoni, Lorenzo Mino, Giovanni Di Liberto, Gianfranco Pacchioni, Gianvito Vilé
Published in: Small, Issue 21, 2025, ISSN 1613-6810
Publisher: Wiley
DOI: 10.1002/SMLL.202408286

Single-Atom Catalysis in Organic Synthesis

Author(s): Vitthal B. Saptal, Vincenzo Ruta, Mark A. Bajada, Gianvito Vilé
Published in: Angewandte Chemie International Edition, 2023, ISSN 1521-3773
Publisher: Wiley-VCH GmbH
DOI: 10.1002/anie.202219306

Strained spiro heterocycles as potential bioisosteres: an update on the synthesis of heteroatom-containing spiro[2.3]hexanes and spiro[3.3]heptanes

Author(s): Philipp Natho; Marco Colella; Renzo Luisi
Published in: Chemical Communications, 2025, ISSN 1364-548X
Publisher: Royal Society of Chemistry
DOI: 10.1039/D5CC00656B

Light-driven C–O coupling of carboxylic acids and alkyl halides over a Ni single-atom catalyst

Author(s): Mark A. Bajada, Giovanni Di Liberto, Sergio Tosoni, Vincenzo Ruta, Lorenzo Mino, Nicolò Allasia, Alessandra Sivo, Gianfranco Pacchioni, Gianvito Vilé
Published in: Nature Synthesis, 2023, ISSN 2731-0582
Publisher: Springer Nature
DOI: 10.1038/s44160-023-00341-3

Synthesis of Aza‐S(VI) Fluorides and Primary Sulfonimidamides from Sulfinylamines

Author(s): Michael Andresini, Laura Marraffa, Defne Şerbetçi, Philipp Natho, Marco Colella, Leonardo Degennaro, Renzo Luisi
Published in: Advanced Synthesis & Catalysis, Issue 367, 2025, ISSN 1615-4150
Publisher: Wiley
DOI: 10.1002/ADSC.202400908

Sustainability and Techno-Economic Assessment of Batch and Flow Chemistry in Seven Industrial Pharmaceutical Processes

Author(s): Mert Can Ince, Brahim Benyahia, Gianvito Vilé
Published in: ACS Sustainable Chemistry & Engineering, Issue 13, 2025, ISSN 2168-0485
Publisher: American Chemical Society (ACS)
DOI: 10.1021/ACSSUSCHEMENG.4C09289

Computer-Aided Retrosynthesis for Greener and Optimal Total Synthesis of a Helicase-primase Inhibitor Active Pharmaceutical Ingredient

Author(s): Rodolfo I. Teixeira; Michael Andresini; Renzo Luisi; Brahim Benyahia
Published in: JACS Au, 2024, ISSN 2691-3704
Publisher: American Chemical Society
DOI: 10.1021/JACSAU.4C00624

Sustainable continuous flow synthesis of β-aminocarbonyls via acid-catalyzed hydration of N-Boc-2-azetines Andresini

Author(s): Michael Andresini, Marco Colella, Roberta Savina Dibenedetto, Elena Graziano, Giuseppe Romanazzi, Andrea Aramini, Leonardo Degennaro, Renzo Luisi
Published in: Reaction Chemistry and Engineering, 2023, ISSN 2058-9883
Publisher: Royal Society of Chemistry
DOI: 10.1039/D3RE00342F

Tunable Preparation of α‐Aminoacyl Fluorides and α‐Fluoroamides via Base‐Induced Cascade Multiple‐Cleavage Processes from Bromodifluorohydrin Reagents and Amines

Author(s): Giulia De Santis, Andrea Maranzana, Federica Lauria, Mauro Spennacchio, Michael Andresini, Rosa Purgatorio, Marco Colella, Renzo Luisi, Leonardo Degennaro
Published in: Advanced Synthesis & Catalysis, Issue 367, 2025, ISSN 1615-4150
Publisher: Wiley
DOI: 10.1002/ADSC.70083

Synthesis of Aza‐S(VI) Fluorides and Primary Sulfonimidamides from Sulfinylamines

Author(s): Andresini, Michael; Marraffa, Laura; Şerbetçi, Defne; Natho, Philipp; Colella, Marco; Degennaro, Leonardo; Luisi, Renzo
Published in: Advanced Synthesis & Catalysis, 2024, ISSN 1615-4169
Publisher: Wiley‑VCH Verlag
DOI: 10.1002/ADSC.202400908

ACS Sustainable Chemistry and Engineering

Author(s): Ince, Mert Can; Benyahia, Brahim; Vilé, Gianvito
Published in: ACS Sustainable Chemistry & Engineering, 2025, ISSN 2168-0485
Publisher: American Chemical Society
DOI: 10.1021/ACSSUSCHEMENG.4C09289

Synergistic Effects in a Nitrogen‐Coordinated Zinc Single‐Atom Catalyst for Efficient CO₂ Cycloaddition

Author(s): Hushan Chand, Nicolò Allasia, Luis A. Cipriano, Giovanni Di Liberto, Ik Seon Kwon, Min Zhang, Gianfranco Pacchioni, Venkata Krishnan, Gianvito Vilé
Published in: ChemCatChem, Issue 17, 2025, ISSN 1867-3880
Publisher: Wiley
DOI: 10.1002/CCTC.202401768

Shifting Lithium Amide Reactivity to the Radical Domain: Regioselective Radical C−H Functionalization of 3‐Iodooxetane for the Synthesis of 1,5‐Dioxaspiro[2.3]hexanes

Author(s): Philipp Natho, Marco Colella, Annarita Vicenti, Giuseppe Romanazzi, Faizan Ullah, Nadeem S. Sheikh, Andrew J. P. White, Francesco Pasca, Renzo Luisi
Published in: Angewandte Chemie International Edition, Issue 64, 2025, ISSN 1433-7851
Publisher: Wiley
DOI: 10.1002/ANIE.202424346

Structured, Shaped, or Printed Single‐Atom Catalysts and Their Applications

Author(s): Jiachengjun Luo, Hushan Chand, Rafael Luque, Alina M. Balu, Gianvito Vilé
Published in: Advanced Functional Materials, Issue 35, 2025, ISSN 1616-301X
Publisher: Wiley
DOI: 10.1002/ADFM.202424514

Synthesis of Alcohols: Streamlined C1 to Cn Hydroxyalkylation through Photoredox Catalysis

Author(s): Francesco Pasca; Yuri Gelato; Michael Andresini; Giuseppe Romanazzi; Leonardo Degennaro; Marco Colella; Renzo Luisi
Published in: Chemical Science, 2024, ISSN 2041-6539
Publisher: Royal Society of Chemistry
DOI: 10.1039/D4SC02696A

Design and optimization of a shared synthetic route for multiple active pharmaceutical ingredients through combined computer aided retrosynthesis and flow chemistry

Author(s): Rodolfo I. Teixeira, Brahim Benyahia
Published in: Chemical Engineering Research and Design, Issue 216, 2025, ISSN 0263-8762
Publisher: Elsevier BV
DOI: 10.1016/J.CHERD.2025.03.004

Nature Communications

Author(s): Dmitrii Nagornîi; Fabian Raymenants; Nikolaos Kaplaneris; Timothy Noël
Published in: Nature Communications, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/S41467-024-49322-W

Strained spiro heterocycles as potential bioisosteres: an update on the synthesis of heteroatom-containing spiro[2.3]hexanes and spiro[3.3]heptanes

Author(s): Philipp Natho, Marco Colella, Renzo Luisi
Published in: Chemical Communications, Issue 61, 2025, ISSN 1359-7345
Publisher: Royal Society of Chemistry (RSC)
DOI: 10.1039/D5CC00656B

Resolving the Nanostructure of Carbon Nitride‐Supported Single‐Atom Catalysts

Author(s): Allasia N.; Xu S.; Jafri S. F.; Borfecchia E.; Cipriano L. A.; Terraneo G.; Tosoni S.; Mino L.; Di Liberto G.; Pacchioni G.; Vile G.
Published in: Small, 2025, ISSN 1613-6829
Publisher: Wiley-VCH Verlag
DOI: 10.1002/SMLL.202408286

Nature Communications

Author(s): Dmitrii Nagornîi; Fabian Raymenants; Nikolaos Kaplaneris; Timothy Noël
Published in: Nature Communications, 2024, ISSN 2041-1723
Publisher: Springer Nature
DOI: 10.1038/S41467-024-49322-W

The Role of Surface Complexes in Ketene Formation from Fatty Acids via Pyrolysis over Silica: from Platform Molecules to Waste Biomass

Author(s): Liana R. Azizova, Tetiana V. Kulik, Borys B. Palianytsia, Mykola M. Ilchenko, German M. Telbiz, Alina M. Balu, Sergiy Tarnavskiy, Rafael Luque, Alberto Roldan, Mykola T. Kartel
Published in: Journal of the American Chemical Society, Issue 49, 2023, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.3c06966

Sustainable upgrading of glycerol into glycidol and its derivatives under continuous-flow conditions

Author(s): Alessandra Sivo; Ilaria Montanari; Mert Can Ince; Gianvito Vilé
Published in: Green Chemistry, 2024, ISSN 1463-9270
Publisher: Royal Society of Chemistry
DOI: 10.1039/D4GC01565G

Generation and Use of Bicyclo[1.1.0]butyllithium under Continuous Flow Conditions

Author(s): Elena Graziano; Marco Colella; Marcus Baumann; Renzo Luisi
Published in: Organic Letters, 2025, ISSN 1523-7052
Publisher: American Chemical Society
DOI: 10.1021/ACS.ORGLETT.5C00705

Structural Effects of Metal Single-Atom Catalysts for Enhanced Photocatalytic Degradation of Gemfibrozil

Author(s): Vincenzo Ruta, Alessandra Sivo, Lorenzo Bonetti, Mark A. Bajada, Gianvito Vilé
Published in: ACS Applied Nano Materials, 2022, ISSN 2574-0970
Publisher: American Chemical Society
DOI: 10.1021/acsanm.2c02859

Photocatalytic C(sp3)–C(sp3) cross-coupling of carboxylic acids and alkyl halides using a nickel complex and carbon nitride

Author(s): Miguel M. de Vries Ibáñez, Luis A. Cipriano, Valeria Lagostina, Andrea Olivati, Mario Chiesa, Annamaria Petrozza, Giovanni Di Liberto, Gianvito Vilé
Published in: Nature Communications, Issue 16, 2025, ISSN 2041-1723
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41467-025-61639-8

<i>SolECOs</i>: a data-driven platform for sustainable and comprehensive solvent selection in pharmaceutical manufacturing

Author(s): Yiming Ma, Shang Gao, Neel Mehta, Qinqing Fu, Wei Li, Brahim Benyahia
Published in: Green Chemistry, Issue 27, 2025, ISSN 1463-9262
Publisher: Royal Society of Chemistry (RSC)
DOI: 10.1039/D5GC04176G

Bifunctional Pd‐Pt Supported Nanoparticles for the Mild Hydrodeoxygenation and Oxidation of Biomass‐Derived Compounds

Author(s): Vincenzo Ruta, Luis A. Cipriano, Giovanni Di Liberto, Robert Wojcieszak, Gianvito Vilé
Published in: ChemSusChem, Issue 18, 2025, ISSN 1864-5631
Publisher: Wiley
DOI: 10.1002/CSSC.202402641

Structured, Shaped, or Printed Single‐Atom Catalysts and Their Applications

Author(s): Jiachengjun Luo; Hushan Chand; Rafael Luque; Alina M. Balu; Gianvito Vilé
Published in: Advanced Functional Materials, 2025, ISSN 1616-3028
Publisher: Wiley‑VCH Verlag
DOI: 10.1002/ADFM.202424514

Generation and Use of Bicyclo[1.1.0]butyllithium under Continuous Flow Conditions

Author(s): Elena Graziano, Marco Colella, Marcus Baumann, Renzo Luisi
Published in: Organic Letters, Issue 27, 2025, ISSN 1523-7060
Publisher: American Chemical Society (ACS)
DOI: 10.1021/ACS.ORGLETT.5C00705

ACS Catalysis

Author(s): Areti Moutsiou; Andrea Olivati; Luis A. Cipriano; Alessandra Sivo; Sean M. Collins; Quentin M. Ramasse; Ik Seon Kwon; Giovanni Di Liberto; Mohamad Kanso; Robert Wojcieszak; Gianfranco Pacchioni; Annamaria Petrozza; Gianvito Vilé
Published in: ACS Catalysis, 2025, ISSN 2155-5435
Publisher: American Chemical Society
DOI: 10.1021/ACSCATAL.4C05208

Copper Single Atoms Chelated on Ligand-Modified Carbon for Ullmann-type C−O Coupling

Author(s): Vincenzo Ruta, Giovanni Di Liberto, Francesco Moriggi, Yurii P. Ivanov, Giorgio Divitini, Gianlorenzo Bussetti, Vincenzina Barbera, Mark A. Bajada, Maurizio Galimberti, Gianfranco Pacchioni, Gianvito Vilé
Published in: ChemSusChem, 2023, ISSN 1864-5631
Publisher: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/CSSC.202301529

3D printed C₃N₄-based structures for photo-, electro-chemical and piezoelectric applications

Author(s): Alessio Massaro, Kiem Giap Nguyen, David Vogelsang Suárez, Artem Glukharev, Chiara Ingrosso, Marinella Striccoli, Ahmet Can Kirlioglu, Suela Kellici, Vesna Middelkoop
Published in: Materials Chemistry Frontiers, Issue 9, 2025, ISSN 2052-1537
Publisher: Royal Society of Chemistry (RSC)
DOI: 10.1039/D5QM00290G

Copper Single‐Atom Catalyst for Efficient C─S Coupling in Thioether Synthesis

Author(s): Theodore A. Gazis, Shilpa Palit, Luis A. Cipriano, Nicolò Allasia, Sean M. Collins, Quentin M. Ramasse, Ik Seon Kwon, Martin Sterrer, Giovanni Di Liberto, Gianvito Vilé
Published in: Angewandte Chemie International Edition, Issue 64, 2025, ISSN 1433-7851
Publisher: Wiley
DOI: 10.1002/ANIE.202510632

Tracking Charge Dynamics in a Silver Single-Atom Catalyst During the Light-Driven Oxidation of Benzyl Alcohol to Benzaldehyde

Author(s): Areti Moutsiou, Andrea Olivati, Luis A. Cipriano, Alessandra Sivo, Sean M. Collins, Quentin M. Ramasse, Ik Seon Kwon, Giovanni Di Liberto, Mohamad Kanso, Robert Wojcieszak, Gianfranco Pacchioni, Annamaria Petrozza, Gianvito Vilé
Published in: ACS Catalysis, Issue 15, 2025, ISSN 2155-5435
Publisher: American Chemical Society (ACS)
DOI: 10.1021/ACSCATAL.4C05208

Synergistic Effects in a Nitrogen‐Coordinated Zinc Single‐Atom Catalyst for Efficient CO₂ Cycloaddition

Author(s): Hushan Chand; Nicolò Allasia; Luis A. Cipriano; Giovanni Di Liberto; Ik Seon Kwon; Min Zhang; Gianfranco Pacchioni; Venkata Krishnan; Gianvito Vilé
Published in: ChemCatChem, 2025, ISSN 1867-3899
Publisher: Wiley‑VCH Verlag
DOI: 10.1002/CCTC.202401768

Forging C−S Bonds on the Azetidine Ring by Continuous Flow Photochemical Addition of Thiols and Disulfides to Azetines

Author(s): Marco Colella, Yuri Gelato, Michael Andresini, Elena Graziano, Gianvito Vilé, Leonardo Degennaro, Renzo Luisi
Published in: European Journal of Organic Chemistry, 2023, ISSN 1099-0690
Publisher: Wiley-VCH GmbH
DOI: 10.1002/ejoc.202300413

Bijel-based mesophotoreactor with integrated carbon nitride for continuous-flow photocatalysis

Author(s): Allasia N.; Nevskyi O.; Marelli M.; Plazl I.; Albertazzi J.; Busini V.; Castiglione F.; Rossi F.; Vile G.
Published in: Chemical Engineering Journal, 2024, ISSN 1873-3212
Publisher: Elsevier
DOI: 10.1016/J.CEJ.2024.155885

Synergistic Effects in a Nitrogen‐Coordinated Zinc Single‐Atom Catalyst for Efficient CO₂ Cycloaddition

Author(s): Hushan Chand, Nicolò Allasia, Luis A. Cipriano, Giovanni Di Liberto, Ik Seon Kwon, Min Zhang, Gianfranco Pacchioni, Venkata Krishnan, Gianvito Vilé
Published in: ChemCatChem, Issue 17, 2025, ISSN 1867-3880
Publisher: Wiley
DOI: 10.1002/CCTC.202401768

Photocatalytic Functionalization of Dehydroalanine‐Derived Peptides in Batch and Flow

Author(s): Kaplaneris, Nikolaos; Akdeniz, Merve; Fillols, Méritxell; Arrighi, Francesca; Raymenants, Fabian; Sanil, Gana; Gryko, Daniel T.; Noël, Timothy
Published in: Angewandte Chemie International Edition, 2024, ISSN 1521-3773
Publisher: Wiley
DOI: 10.1002/ANIE.202403271

Sustainability assessment of single-atom catalysts in the transition to greener chemical processes

Author(s): Mark A. Bajada, Maxim Tschulkow, Gianvito Vilé
Published in: Cell Reports Sustainability, Issue 2, 2025, ISSN 2949-7906
Publisher: Elsevier BV
DOI: 10.1016/J.CRSUS.2024.100286

Digital design and optimization of the integrated synthesis and crystallization process using data‐driven approaches

Author(s): Yiming Ma, Wei Li, Jiaxu Liu, Gao Shang, Huaiyu Yang, Junbo Gong, Zoltan K. Nagy, Brahim Benyahia
Published in: AIChE Journal, Issue 71, 2025, ISSN 0001-1541
Publisher: Wiley
DOI: 10.1002/AIC.18931

Benign-by-design sustainable protocol for the synthesis of furosemide

Author(s): Francesco Minio, Airovict Hernández Torriente, Alina M. Balu, Luigi Vaccaro, Sameh M. Osman, Rafael Luque, Tripti Chhabra
Published in: Sustainable Chemistry and Pharmacy, Issue 39, 2024, ISSN 2352-5541
Publisher: Elsevier BV
DOI: 10.1016/J.SCP.2024.101600

Brewing sustainability: Continuous flow Ru-supported hydrochar from bagasse beer waste for renewable N-containing chemicals via reductive amination of biomass-derived platform molecules

Author(s): Viviana Bressi, Francesco Minio, Alina M Balu, Enrique Rodríguez-Castellón, Assunta Marrocchi, Luigi Vaccaro, Claudia Espro, Sameh M Osman, Rafael Luque, Tripti Chhabra
Published in: Sustainable Chemistry and Pharmacy, 2024, ISSN 2352-5541
Publisher: Elsevier
DOI: 10.1016/j.scp.2024.101436

Conference proceedings (1)

Preparation of Nanosized Mesoporous Metal Oxides

Author(s): Olena Korchuganova, Emiliia Tantsiura, Kamila Abuzarova, Alina M. Balu
Published in: ECCS 2025, 2025
Publisher: MDPI
DOI: 10.3390/CHEMPROC2025017007

Intellectual Property Rights

Patent (2)

THREE-DIMENSIONAL POROUS STRUCTURE AND METHOD FOR PRODUCING IT

Application/Publication number: 20 23076799
Date: 2023-09-27
Applicant(s): VLAAMSE INSTELLING VOOR TECHNOLOGISCH ONDERZOEK N.V.

THREE-DIMENSIONAL POROUS STRUCTURE AND METHOD FOR PRODUCING IT

Application/Publication number: 20 23076799
Date: 2023-09-27
Applicant(s): C2CAT BV