MERGING SUSTAINABLE AND DIGITAL CHEMICAL TECHNOLOGIES FOR THE DEVELOPMENT OF GREENER-BY-DESIGN PHARMACEUTICALS

Información del proyecto

SusPharma

Identificador del acuerdo de subvención: 101057430

DOI

10.3030/101057430

Fecha de la firma de la CE 23 Mayo 2022

Fecha de inicio 1 Septiembre 2022

Fecha de finalización 31 Agosto 2026

Financiado con arreglo a

• Health

Coste total

€ 6 205 435,00

Aportación de la UE

€ 6 205 434,50

Coordinado por

UNIVERSITA DEGLI STUDI DI BARI ALDO MORO
Italy

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Websites, patent fillings, videos etc. (2)

Data Management plan.
Website, Twitter account and communication material.

Publicaciones

Peer reviewed articles (25)

Nature Communications

Autores: Gianvito Vilé; Miguel M. de Vries Ibáñez; Luis A. Cipriano; Giovanni Di Liberto
Publicado en: Nature Communications, 2025, ISSN 2041-1723
Editor: Nature Portfolio
DOI: 10.1038/S41467-025-61639-8

Nanostructured Carbon Nitride for Continuous-Flow Trifluoromethylation of (Hetero)arenes

Autores: Alessandra Sivo, Vincenzo Ruta, Vittoria Granata, Oleksandr Savateev, Mark A. Bajada, and Gianvito Vilé
Publicado en: ACS Sustainable Chemistry & Engineering, 2023, ISSN 2168-0485
Editor: American Chemical Society
DOI: 10.1021/ACSSUSCHEMENG.3C00176

Continuous Flow Decarboxylative Monofluoroalkylation Enabled by Photoredox Catalysis

Autores: Pasca, Francesco; Gelato, Yuri; Andresini, Michael; Serbetci, Defne; Natho, Philipp; Romanazzi, Giuseppe; Degennaro, Leonardo; Colella, Marco; Luisi, Renzo
Publicado en: JACS Au, 2025, ISSN 2691-3704
Editor: American Chemical Society
DOI: 10.1021/JACSAU.4C00902

Single-Atom Catalysis in Organic Synthesis

Autores: Vitthal B. Saptal, Vincenzo Ruta, Mark A. Bajada, Gianvito Vilé
Publicado en: Angewandte Chemie International Edition, 2023, ISSN 1521-3773
Editor: Wiley-VCH GmbH
DOI: 10.1002/anie.202219306

Strained spiro heterocycles as potential bioisosteres: an update on the synthesis of heteroatom-containing spiro[2.3]hexanes and spiro[3.3]heptanes

Autores: Philipp Natho; Marco Colella; Renzo Luisi
Publicado en: Chemical Communications, 2025, ISSN 1364-548X
Editor: Royal Society of Chemistry
DOI: 10.1039/D5CC00656B

Light-driven C–O coupling of carboxylic acids and alkyl halides over a Ni single-atom catalyst

Autores: Mark A. Bajada, Giovanni Di Liberto, Sergio Tosoni, Vincenzo Ruta, Lorenzo Mino, Nicolò Allasia, Alessandra Sivo, Gianfranco Pacchioni, Gianvito Vilé
Publicado en: Nature Synthesis, 2023, ISSN 2731-0582
Editor: Springer Nature
DOI: 10.1038/s44160-023-00341-3

Computer-Aided Retrosynthesis for Greener and Optimal Total Synthesis of a Helicase-primase Inhibitor Active Pharmaceutical Ingredient

Autores: Rodolfo I. Teixeira; Michael Andresini; Renzo Luisi; Brahim Benyahia
Publicado en: JACS Au, 2024, ISSN 2691-3704
Editor: American Chemical Society
DOI: 10.1021/JACSAU.4C00624

Sustainable continuous flow synthesis of β-aminocarbonyls via acid-catalyzed hydration of N-Boc-2-azetines Andresini

Autores: Michael Andresini, Marco Colella, Roberta Savina Dibenedetto, Elena Graziano, Giuseppe Romanazzi, Andrea Aramini, Leonardo Degennaro, Renzo Luisi
Publicado en: Reaction Chemistry and Engineering, 2023, ISSN 2058-9883
Editor: Royal Society of Chemistry
DOI: 10.1039/D3RE00342F

Synthesis of Aza‐S(VI) Fluorides and Primary Sulfonimidamides from Sulfinylamines

Autores: Andresini, Michael; Marraffa, Laura; Şerbetçi, Defne; Natho, Philipp; Colella, Marco; Degennaro, Leonardo; Luisi, Renzo
Publicado en: Advanced Synthesis & Catalysis, 2024, ISSN 1615-4169
Editor: Wiley‑VCH Verlag
DOI: 10.1002/ADSC.202400908

ACS Sustainable Chemistry and Engineering

Autores: Ince, Mert Can; Benyahia, Brahim; Vilé, Gianvito
Publicado en: ACS Sustainable Chemistry & Engineering, 2025, ISSN 2168-0485
Editor: American Chemical Society
DOI: 10.1021/ACSSUSCHEMENG.4C09289

Synthesis of Alcohols: Streamlined C1 to Cn Hydroxyalkylation through Photoredox Catalysis

Autores: Francesco Pasca; Yuri Gelato; Michael Andresini; Giuseppe Romanazzi; Leonardo Degennaro; Marco Colella; Renzo Luisi
Publicado en: Chemical Science, 2024, ISSN 2041-6539
Editor: Royal Society of Chemistry
DOI: 10.1039/D4SC02696A

Resolving the Nanostructure of Carbon Nitride‐Supported Single‐Atom Catalysts

Autores: Allasia N.; Xu S.; Jafri S. F.; Borfecchia E.; Cipriano L. A.; Terraneo G.; Tosoni S.; Mino L.; Di Liberto G.; Pacchioni G.; Vile G.
Publicado en: Small, 2025, ISSN 1613-6829
Editor: Wiley-VCH Verlag
DOI: 10.1002/SMLL.202408286

Nature Communications

Autores: Dmitrii Nagornîi; Fabian Raymenants; Nikolaos Kaplaneris; Timothy Noël
Publicado en: Nature Communications, 2024, ISSN 2041-1723
Editor: Springer Nature
DOI: 10.1038/S41467-024-49322-W

The Role of Surface Complexes in Ketene Formation from Fatty Acids via Pyrolysis over Silica: from Platform Molecules to Waste Biomass

Autores: Liana R. Azizova, Tetiana V. Kulik, Borys B. Palianytsia, Mykola M. Ilchenko, German M. Telbiz, Alina M. Balu, Sergiy Tarnavskiy, Rafael Luque, Alberto Roldan, Mykola T. Kartel
Publicado en: Journal of the American Chemical Society, Edición 49, 2023, ISSN 0002-7863
Editor: American Chemical Society
DOI: 10.1021/jacs.3c06966

Sustainable upgrading of glycerol into glycidol and its derivatives under continuous-flow conditions

Autores: Alessandra Sivo; Ilaria Montanari; Mert Can Ince; Gianvito Vilé
Publicado en: Green Chemistry, 2024, ISSN 1463-9270
Editor: Royal Society of Chemistry
DOI: 10.1039/D4GC01565G

Generation and Use of Bicyclo[1.1.0]butyllithium under Continuous Flow Conditions

Autores: Elena Graziano; Marco Colella; Marcus Baumann; Renzo Luisi
Publicado en: Organic Letters, 2025, ISSN 1523-7052
Editor: American Chemical Society
DOI: 10.1021/ACS.ORGLETT.5C00705

Structural Effects of Metal Single-Atom Catalysts for Enhanced Photocatalytic Degradation of Gemfibrozil

Autores: Vincenzo Ruta, Alessandra Sivo, Lorenzo Bonetti, Mark A. Bajada, Gianvito Vilé
Publicado en: ACS Applied Nano Materials, 2022, ISSN 2574-0970
Editor: American Chemical Society
DOI: 10.1021/acsanm.2c02859

Structured, Shaped, or Printed Single‐Atom Catalysts and Their Applications

Autores: Jiachengjun Luo; Hushan Chand; Rafael Luque; Alina M. Balu; Gianvito Vilé
Publicado en: Advanced Functional Materials, 2025, ISSN 1616-3028
Editor: Wiley‑VCH Verlag
DOI: 10.1002/ADFM.202424514

ACS Catalysis

Autores: Areti Moutsiou; Andrea Olivati; Luis A. Cipriano; Alessandra Sivo; Sean M. Collins; Quentin M. Ramasse; Ik Seon Kwon; Giovanni Di Liberto; Mohamad Kanso; Robert Wojcieszak; Gianfranco Pacchioni; Annamaria Petrozza; Gianvito Vilé
Publicado en: ACS Catalysis, 2025, ISSN 2155-5435
Editor: American Chemical Society
DOI: 10.1021/ACSCATAL.4C05208

Copper Single Atoms Chelated on Ligand-Modified Carbon for Ullmann-type C−O Coupling

Autores: Vincenzo Ruta, Giovanni Di Liberto, Francesco Moriggi, Yurii P. Ivanov, Giorgio Divitini, Gianlorenzo Bussetti, Vincenzina Barbera, Mark A. Bajada, Maurizio Galimberti, Gianfranco Pacchioni, Gianvito Vilé
Publicado en: ChemSusChem, 2023, ISSN 1864-5631
Editor: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/CSSC.202301529

Synergistic Effects in a Nitrogen‐Coordinated Zinc Single‐Atom Catalyst for Efficient CO₂ Cycloaddition

Autores: Hushan Chand; Nicolò Allasia; Luis A. Cipriano; Giovanni Di Liberto; Ik Seon Kwon; Min Zhang; Gianfranco Pacchioni; Venkata Krishnan; Gianvito Vilé
Publicado en: ChemCatChem, 2025, ISSN 1867-3899
Editor: Wiley‑VCH Verlag
DOI: 10.1002/CCTC.202401768

Forging C−S Bonds on the Azetidine Ring by Continuous Flow Photochemical Addition of Thiols and Disulfides to Azetines

Autores: Marco Colella, Yuri Gelato, Michael Andresini, Elena Graziano, Gianvito Vilé, Leonardo Degennaro, Renzo Luisi
Publicado en: European Journal of Organic Chemistry, 2023, ISSN 1099-0690
Editor: Wiley-VCH GmbH
DOI: 10.1002/ejoc.202300413

Bijel-based mesophotoreactor with integrated carbon nitride for continuous-flow photocatalysis

Autores: Allasia N.; Nevskyi O.; Marelli M.; Plazl I.; Albertazzi J.; Busini V.; Castiglione F.; Rossi F.; Vile G.
Publicado en: Chemical Engineering Journal, 2024, ISSN 1873-3212
Editor: Elsevier
DOI: 10.1016/J.CEJ.2024.155885

Photocatalytic Functionalization of Dehydroalanine‐Derived Peptides in Batch and Flow

Autores: Kaplaneris, Nikolaos; Akdeniz, Merve; Fillols, Méritxell; Arrighi, Francesca; Raymenants, Fabian; Sanil, Gana; Gryko, Daniel T.; Noël, Timothy
Publicado en: Angewandte Chemie International Edition, 2024, ISSN 1521-3773
Editor: Wiley
DOI: 10.1002/ANIE.202403271

Brewing sustainability: Continuous flow Ru-supported hydrochar from bagasse beer waste for renewable N-containing chemicals via reductive amination of biomass-derived platform molecules

Autores: Viviana Bressi, Francesco Minio, Alina M Balu, Enrique Rodríguez-Castellón, Assunta Marrocchi, Luigi Vaccaro, Claudia Espro, Sameh M Osman, Rafael Luque, Tripti Chhabra
Publicado en: Sustainable Chemistry and Pharmacy, 2024, ISSN 2352-5541
Editor: Elsevier
DOI: 10.1016/j.scp.2024.101436

Derechos de propiedad intelectual

Patent (2)

THREE-DIMENSIONAL POROUS STRUCTURE AND METHOD FOR PRODUCING IT

Número de solicitud/publicación: 20 23076799
Fecha: 2023-09-27
Solicitante(s): VLAAMSE INSTELLING VOOR TECHNOLOGISCH ONDERZOEK N.V.

THREE-DIMENSIONAL POROUS STRUCTURE AND METHOD FOR PRODUCING IT

Número de solicitud/publicación: 20 23076799
Fecha: 2023-09-27
Solicitante(s): C2CAT BV