MERGING SUSTAINABLE AND DIGITAL CHEMICAL TECHNOLOGIES FOR THE DEVELOPMENT OF GREENER-BY-DESIGN PHARMACEUTICALS

Información del proyecto

SusPharma

Identificador del acuerdo de subvención: 101057430

DOI

10.3030/101057430

Fecha de la firma de la CE 23 Mayo 2022

Fecha de inicio 1 Septiembre 2022

Fecha de finalización 31 Agosto 2026

Financiado con arreglo a

• Health

Coste total

€ 6 205 435,00

Aportación de la UE

€ 6 205 434,50

Coordinado por

UNIVERSITA DEGLI STUDI DI BARI ALDO MORO
Italy

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Websites, patent fillings, videos etc. (2)

Data Management plan.
Website, Twitter account and communication material.

Publicaciones

Peer reviewed articles (46)

Nature Communications

Autores: Gianvito Vilé; Miguel M. de Vries Ibáñez; Luis A. Cipriano; Giovanni Di Liberto
Publicado en: Nature Communications, 2025, ISSN 2041-1723
Editor: Nature Portfolio
DOI: 10.1038/S41467-025-61639-8

Nanostructured Carbon Nitride for Continuous-Flow Trifluoromethylation of (Hetero)arenes

Autores: Alessandra Sivo, Vincenzo Ruta, Vittoria Granata, Oleksandr Savateev, Mark A. Bajada, and Gianvito Vilé
Publicado en: ACS Sustainable Chemistry & Engineering, 2023, ISSN 2168-0485
Editor: American Chemical Society
DOI: 10.1021/ACSSUSCHEMENG.3C00176

Continuous Flow Decarboxylative Monofluoroalkylation Enabled by Photoredox Catalysis

Autores: Pasca, Francesco; Gelato, Yuri; Andresini, Michael; Serbetci, Defne; Natho, Philipp; Romanazzi, Giuseppe; Degennaro, Leonardo; Colella, Marco; Luisi, Renzo
Publicado en: JACS Au, 2025, ISSN 2691-3704
Editor: American Chemical Society
DOI: 10.1021/JACSAU.4C00902

Resolving the Nanostructure of Carbon Nitride‐Supported Single‐Atom Catalysts

Autores: Nicolò Allasia, Shuai Xu, Sadaf Fatima Jafri, Elisa Borfecchia, Luis A. Cipriano, Giancarlo Terraneo, Sergio Tosoni, Lorenzo Mino, Giovanni Di Liberto, Gianfranco Pacchioni, Gianvito Vilé
Publicado en: Small, Edición 21, 2025, ISSN 1613-6810
Editor: Wiley
DOI: 10.1002/SMLL.202408286

Single-Atom Catalysis in Organic Synthesis

Autores: Vitthal B. Saptal, Vincenzo Ruta, Mark A. Bajada, Gianvito Vilé
Publicado en: Angewandte Chemie International Edition, 2023, ISSN 1521-3773
Editor: Wiley-VCH GmbH
DOI: 10.1002/anie.202219306

Strained spiro heterocycles as potential bioisosteres: an update on the synthesis of heteroatom-containing spiro[2.3]hexanes and spiro[3.3]heptanes

Autores: Philipp Natho; Marco Colella; Renzo Luisi
Publicado en: Chemical Communications, 2025, ISSN 1364-548X
Editor: Royal Society of Chemistry
DOI: 10.1039/D5CC00656B

Light-driven C–O coupling of carboxylic acids and alkyl halides over a Ni single-atom catalyst

Autores: Mark A. Bajada, Giovanni Di Liberto, Sergio Tosoni, Vincenzo Ruta, Lorenzo Mino, Nicolò Allasia, Alessandra Sivo, Gianfranco Pacchioni, Gianvito Vilé
Publicado en: Nature Synthesis, 2023, ISSN 2731-0582
Editor: Springer Nature
DOI: 10.1038/s44160-023-00341-3

Synthesis of Aza‐S(VI) Fluorides and Primary Sulfonimidamides from Sulfinylamines

Autores: Michael Andresini, Laura Marraffa, Defne Şerbetçi, Philipp Natho, Marco Colella, Leonardo Degennaro, Renzo Luisi
Publicado en: Advanced Synthesis & Catalysis, Edición 367, 2025, ISSN 1615-4150
Editor: Wiley
DOI: 10.1002/ADSC.202400908

Sustainability and Techno-Economic Assessment of Batch and Flow Chemistry in Seven Industrial Pharmaceutical Processes

Autores: Mert Can Ince, Brahim Benyahia, Gianvito Vilé
Publicado en: ACS Sustainable Chemistry & Engineering, Edición 13, 2025, ISSN 2168-0485
Editor: American Chemical Society (ACS)
DOI: 10.1021/ACSSUSCHEMENG.4C09289

Computer-Aided Retrosynthesis for Greener and Optimal Total Synthesis of a Helicase-primase Inhibitor Active Pharmaceutical Ingredient

Autores: Rodolfo I. Teixeira; Michael Andresini; Renzo Luisi; Brahim Benyahia
Publicado en: JACS Au, 2024, ISSN 2691-3704
Editor: American Chemical Society
DOI: 10.1021/JACSAU.4C00624

Sustainable continuous flow synthesis of β-aminocarbonyls via acid-catalyzed hydration of N-Boc-2-azetines Andresini

Autores: Michael Andresini, Marco Colella, Roberta Savina Dibenedetto, Elena Graziano, Giuseppe Romanazzi, Andrea Aramini, Leonardo Degennaro, Renzo Luisi
Publicado en: Reaction Chemistry and Engineering, 2023, ISSN 2058-9883
Editor: Royal Society of Chemistry
DOI: 10.1039/D3RE00342F

Tunable Preparation of α‐Aminoacyl Fluorides and α‐Fluoroamides via Base‐Induced Cascade Multiple‐Cleavage Processes from Bromodifluorohydrin Reagents and Amines

Autores: Giulia De Santis, Andrea Maranzana, Federica Lauria, Mauro Spennacchio, Michael Andresini, Rosa Purgatorio, Marco Colella, Renzo Luisi, Leonardo Degennaro
Publicado en: Advanced Synthesis & Catalysis, Edición 367, 2025, ISSN 1615-4150
Editor: Wiley
DOI: 10.1002/ADSC.70083

Synthesis of Aza‐S(VI) Fluorides and Primary Sulfonimidamides from Sulfinylamines

Autores: Andresini, Michael; Marraffa, Laura; Şerbetçi, Defne; Natho, Philipp; Colella, Marco; Degennaro, Leonardo; Luisi, Renzo
Publicado en: Advanced Synthesis & Catalysis, 2024, ISSN 1615-4169
Editor: Wiley‑VCH Verlag
DOI: 10.1002/ADSC.202400908

ACS Sustainable Chemistry and Engineering

Autores: Ince, Mert Can; Benyahia, Brahim; Vilé, Gianvito
Publicado en: ACS Sustainable Chemistry & Engineering, 2025, ISSN 2168-0485
Editor: American Chemical Society
DOI: 10.1021/ACSSUSCHEMENG.4C09289

Synergistic Effects in a Nitrogen‐Coordinated Zinc Single‐Atom Catalyst for Efficient CO₂ Cycloaddition

Autores: Hushan Chand, Nicolò Allasia, Luis A. Cipriano, Giovanni Di Liberto, Ik Seon Kwon, Min Zhang, Gianfranco Pacchioni, Venkata Krishnan, Gianvito Vilé
Publicado en: ChemCatChem, Edición 17, 2025, ISSN 1867-3880
Editor: Wiley
DOI: 10.1002/CCTC.202401768

Shifting Lithium Amide Reactivity to the Radical Domain: Regioselective Radical C−H Functionalization of 3‐Iodooxetane for the Synthesis of 1,5‐Dioxaspiro[2.3]hexanes

Autores: Philipp Natho, Marco Colella, Annarita Vicenti, Giuseppe Romanazzi, Faizan Ullah, Nadeem S. Sheikh, Andrew J. P. White, Francesco Pasca, Renzo Luisi
Publicado en: Angewandte Chemie International Edition, Edición 64, 2025, ISSN 1433-7851
Editor: Wiley
DOI: 10.1002/ANIE.202424346

Structured, Shaped, or Printed Single‐Atom Catalysts and Their Applications

Autores: Jiachengjun Luo, Hushan Chand, Rafael Luque, Alina M. Balu, Gianvito Vilé
Publicado en: Advanced Functional Materials, Edición 35, 2025, ISSN 1616-301X
Editor: Wiley
DOI: 10.1002/ADFM.202424514

Synthesis of Alcohols: Streamlined C1 to Cn Hydroxyalkylation through Photoredox Catalysis

Autores: Francesco Pasca; Yuri Gelato; Michael Andresini; Giuseppe Romanazzi; Leonardo Degennaro; Marco Colella; Renzo Luisi
Publicado en: Chemical Science, 2024, ISSN 2041-6539
Editor: Royal Society of Chemistry
DOI: 10.1039/D4SC02696A

Design and optimization of a shared synthetic route for multiple active pharmaceutical ingredients through combined computer aided retrosynthesis and flow chemistry

Autores: Rodolfo I. Teixeira, Brahim Benyahia
Publicado en: Chemical Engineering Research and Design, Edición 216, 2025, ISSN 0263-8762
Editor: Elsevier BV
DOI: 10.1016/J.CHERD.2025.03.004

Nature Communications

Autores: Dmitrii Nagornîi; Fabian Raymenants; Nikolaos Kaplaneris; Timothy Noël
Publicado en: Nature Communications, 2024, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/S41467-024-49322-W

Strained spiro heterocycles as potential bioisosteres: an update on the synthesis of heteroatom-containing spiro[2.3]hexanes and spiro[3.3]heptanes

Autores: Philipp Natho, Marco Colella, Renzo Luisi
Publicado en: Chemical Communications, Edición 61, 2025, ISSN 1359-7345
Editor: Royal Society of Chemistry (RSC)
DOI: 10.1039/D5CC00656B

Resolving the Nanostructure of Carbon Nitride‐Supported Single‐Atom Catalysts

Autores: Allasia N.; Xu S.; Jafri S. F.; Borfecchia E.; Cipriano L. A.; Terraneo G.; Tosoni S.; Mino L.; Di Liberto G.; Pacchioni G.; Vile G.
Publicado en: Small, 2025, ISSN 1613-6829
Editor: Wiley-VCH Verlag
DOI: 10.1002/SMLL.202408286

Nature Communications

Autores: Dmitrii Nagornîi; Fabian Raymenants; Nikolaos Kaplaneris; Timothy Noël
Publicado en: Nature Communications, 2024, ISSN 2041-1723
Editor: Springer Nature
DOI: 10.1038/S41467-024-49322-W

The Role of Surface Complexes in Ketene Formation from Fatty Acids via Pyrolysis over Silica: from Platform Molecules to Waste Biomass

Autores: Liana R. Azizova, Tetiana V. Kulik, Borys B. Palianytsia, Mykola M. Ilchenko, German M. Telbiz, Alina M. Balu, Sergiy Tarnavskiy, Rafael Luque, Alberto Roldan, Mykola T. Kartel
Publicado en: Journal of the American Chemical Society, Edición 49, 2023, ISSN 0002-7863
Editor: American Chemical Society
DOI: 10.1021/jacs.3c06966

Sustainable upgrading of glycerol into glycidol and its derivatives under continuous-flow conditions

Autores: Alessandra Sivo; Ilaria Montanari; Mert Can Ince; Gianvito Vilé
Publicado en: Green Chemistry, 2024, ISSN 1463-9270
Editor: Royal Society of Chemistry
DOI: 10.1039/D4GC01565G

Generation and Use of Bicyclo[1.1.0]butyllithium under Continuous Flow Conditions

Autores: Elena Graziano; Marco Colella; Marcus Baumann; Renzo Luisi
Publicado en: Organic Letters, 2025, ISSN 1523-7052
Editor: American Chemical Society
DOI: 10.1021/ACS.ORGLETT.5C00705

Structural Effects of Metal Single-Atom Catalysts for Enhanced Photocatalytic Degradation of Gemfibrozil

Autores: Vincenzo Ruta, Alessandra Sivo, Lorenzo Bonetti, Mark A. Bajada, Gianvito Vilé
Publicado en: ACS Applied Nano Materials, 2022, ISSN 2574-0970
Editor: American Chemical Society
DOI: 10.1021/acsanm.2c02859

Photocatalytic C(sp3)–C(sp3) cross-coupling of carboxylic acids and alkyl halides using a nickel complex and carbon nitride

Autores: Miguel M. de Vries Ibáñez, Luis A. Cipriano, Valeria Lagostina, Andrea Olivati, Mario Chiesa, Annamaria Petrozza, Giovanni Di Liberto, Gianvito Vilé
Publicado en: Nature Communications, Edición 16, 2025, ISSN 2041-1723
Editor: Springer Science and Business Media LLC
DOI: 10.1038/S41467-025-61639-8

<i>SolECOs</i>: a data-driven platform for sustainable and comprehensive solvent selection in pharmaceutical manufacturing

Autores: Yiming Ma, Shang Gao, Neel Mehta, Qinqing Fu, Wei Li, Brahim Benyahia
Publicado en: Green Chemistry, Edición 27, 2025, ISSN 1463-9262
Editor: Royal Society of Chemistry (RSC)
DOI: 10.1039/D5GC04176G

Bifunctional Pd‐Pt Supported Nanoparticles for the Mild Hydrodeoxygenation and Oxidation of Biomass‐Derived Compounds

Autores: Vincenzo Ruta, Luis A. Cipriano, Giovanni Di Liberto, Robert Wojcieszak, Gianvito Vilé
Publicado en: ChemSusChem, Edición 18, 2025, ISSN 1864-5631
Editor: Wiley
DOI: 10.1002/CSSC.202402641

Structured, Shaped, or Printed Single‐Atom Catalysts and Their Applications

Autores: Jiachengjun Luo; Hushan Chand; Rafael Luque; Alina M. Balu; Gianvito Vilé
Publicado en: Advanced Functional Materials, 2025, ISSN 1616-3028
Editor: Wiley‑VCH Verlag
DOI: 10.1002/ADFM.202424514

Generation and Use of Bicyclo[1.1.0]butyllithium under Continuous Flow Conditions

Autores: Elena Graziano, Marco Colella, Marcus Baumann, Renzo Luisi
Publicado en: Organic Letters, Edición 27, 2025, ISSN 1523-7060
Editor: American Chemical Society (ACS)
DOI: 10.1021/ACS.ORGLETT.5C00705

ACS Catalysis

Autores: Areti Moutsiou; Andrea Olivati; Luis A. Cipriano; Alessandra Sivo; Sean M. Collins; Quentin M. Ramasse; Ik Seon Kwon; Giovanni Di Liberto; Mohamad Kanso; Robert Wojcieszak; Gianfranco Pacchioni; Annamaria Petrozza; Gianvito Vilé
Publicado en: ACS Catalysis, 2025, ISSN 2155-5435
Editor: American Chemical Society
DOI: 10.1021/ACSCATAL.4C05208

Copper Single Atoms Chelated on Ligand-Modified Carbon for Ullmann-type C−O Coupling

Autores: Vincenzo Ruta, Giovanni Di Liberto, Francesco Moriggi, Yurii P. Ivanov, Giorgio Divitini, Gianlorenzo Bussetti, Vincenzina Barbera, Mark A. Bajada, Maurizio Galimberti, Gianfranco Pacchioni, Gianvito Vilé
Publicado en: ChemSusChem, 2023, ISSN 1864-5631
Editor: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/CSSC.202301529

3D printed C₃N₄-based structures for photo-, electro-chemical and piezoelectric applications

Autores: Alessio Massaro, Kiem Giap Nguyen, David Vogelsang Suárez, Artem Glukharev, Chiara Ingrosso, Marinella Striccoli, Ahmet Can Kirlioglu, Suela Kellici, Vesna Middelkoop
Publicado en: Materials Chemistry Frontiers, Edición 9, 2025, ISSN 2052-1537
Editor: Royal Society of Chemistry (RSC)
DOI: 10.1039/D5QM00290G

Copper Single‐Atom Catalyst for Efficient C─S Coupling in Thioether Synthesis

Autores: Theodore A. Gazis, Shilpa Palit, Luis A. Cipriano, Nicolò Allasia, Sean M. Collins, Quentin M. Ramasse, Ik Seon Kwon, Martin Sterrer, Giovanni Di Liberto, Gianvito Vilé
Publicado en: Angewandte Chemie International Edition, Edición 64, 2025, ISSN 1433-7851
Editor: Wiley
DOI: 10.1002/ANIE.202510632

Tracking Charge Dynamics in a Silver Single-Atom Catalyst During the Light-Driven Oxidation of Benzyl Alcohol to Benzaldehyde

Autores: Areti Moutsiou, Andrea Olivati, Luis A. Cipriano, Alessandra Sivo, Sean M. Collins, Quentin M. Ramasse, Ik Seon Kwon, Giovanni Di Liberto, Mohamad Kanso, Robert Wojcieszak, Gianfranco Pacchioni, Annamaria Petrozza, Gianvito Vilé
Publicado en: ACS Catalysis, Edición 15, 2025, ISSN 2155-5435
Editor: American Chemical Society (ACS)
DOI: 10.1021/ACSCATAL.4C05208

Synergistic Effects in a Nitrogen‐Coordinated Zinc Single‐Atom Catalyst for Efficient CO₂ Cycloaddition

Autores: Hushan Chand; Nicolò Allasia; Luis A. Cipriano; Giovanni Di Liberto; Ik Seon Kwon; Min Zhang; Gianfranco Pacchioni; Venkata Krishnan; Gianvito Vilé
Publicado en: ChemCatChem, 2025, ISSN 1867-3899
Editor: Wiley‑VCH Verlag
DOI: 10.1002/CCTC.202401768

Forging C−S Bonds on the Azetidine Ring by Continuous Flow Photochemical Addition of Thiols and Disulfides to Azetines

Autores: Marco Colella, Yuri Gelato, Michael Andresini, Elena Graziano, Gianvito Vilé, Leonardo Degennaro, Renzo Luisi
Publicado en: European Journal of Organic Chemistry, 2023, ISSN 1099-0690
Editor: Wiley-VCH GmbH
DOI: 10.1002/ejoc.202300413

Bijel-based mesophotoreactor with integrated carbon nitride for continuous-flow photocatalysis

Autores: Allasia N.; Nevskyi O.; Marelli M.; Plazl I.; Albertazzi J.; Busini V.; Castiglione F.; Rossi F.; Vile G.
Publicado en: Chemical Engineering Journal, 2024, ISSN 1873-3212
Editor: Elsevier
DOI: 10.1016/J.CEJ.2024.155885

Synergistic Effects in a Nitrogen‐Coordinated Zinc Single‐Atom Catalyst for Efficient CO₂ Cycloaddition

Autores: Hushan Chand, Nicolò Allasia, Luis A. Cipriano, Giovanni Di Liberto, Ik Seon Kwon, Min Zhang, Gianfranco Pacchioni, Venkata Krishnan, Gianvito Vilé
Publicado en: ChemCatChem, Edición 17, 2025, ISSN 1867-3880
Editor: Wiley
DOI: 10.1002/CCTC.202401768

Photocatalytic Functionalization of Dehydroalanine‐Derived Peptides in Batch and Flow

Autores: Kaplaneris, Nikolaos; Akdeniz, Merve; Fillols, Méritxell; Arrighi, Francesca; Raymenants, Fabian; Sanil, Gana; Gryko, Daniel T.; Noël, Timothy
Publicado en: Angewandte Chemie International Edition, 2024, ISSN 1521-3773
Editor: Wiley
DOI: 10.1002/ANIE.202403271

Sustainability assessment of single-atom catalysts in the transition to greener chemical processes

Autores: Mark A. Bajada, Maxim Tschulkow, Gianvito Vilé
Publicado en: Cell Reports Sustainability, Edición 2, 2025, ISSN 2949-7906
Editor: Elsevier BV
DOI: 10.1016/J.CRSUS.2024.100286

Digital design and optimization of the integrated synthesis and crystallization process using data‐driven approaches

Autores: Yiming Ma, Wei Li, Jiaxu Liu, Gao Shang, Huaiyu Yang, Junbo Gong, Zoltan K. Nagy, Brahim Benyahia
Publicado en: AIChE Journal, Edición 71, 2025, ISSN 0001-1541
Editor: Wiley
DOI: 10.1002/AIC.18931

Benign-by-design sustainable protocol for the synthesis of furosemide

Autores: Francesco Minio, Airovict Hernández Torriente, Alina M. Balu, Luigi Vaccaro, Sameh M. Osman, Rafael Luque, Tripti Chhabra
Publicado en: Sustainable Chemistry and Pharmacy, Edición 39, 2024, ISSN 2352-5541
Editor: Elsevier BV
DOI: 10.1016/J.SCP.2024.101600

Brewing sustainability: Continuous flow Ru-supported hydrochar from bagasse beer waste for renewable N-containing chemicals via reductive amination of biomass-derived platform molecules

Autores: Viviana Bressi, Francesco Minio, Alina M Balu, Enrique Rodríguez-Castellón, Assunta Marrocchi, Luigi Vaccaro, Claudia Espro, Sameh M Osman, Rafael Luque, Tripti Chhabra
Publicado en: Sustainable Chemistry and Pharmacy, 2024, ISSN 2352-5541
Editor: Elsevier
DOI: 10.1016/j.scp.2024.101436

Conference proceedings (1)

Preparation of Nanosized Mesoporous Metal Oxides

Autores: Olena Korchuganova, Emiliia Tantsiura, Kamila Abuzarova, Alina M. Balu
Publicado en: ECCS 2025, 2025
Editor: MDPI
DOI: 10.3390/CHEMPROC2025017007

Derechos de propiedad intelectual

Patent (2)

THREE-DIMENSIONAL POROUS STRUCTURE AND METHOD FOR PRODUCING IT

Número de solicitud/publicación: 20 23076799
Fecha: 2023-09-27
Solicitante(s): VLAAMSE INSTELLING VOOR TECHNOLOGISCH ONDERZOEK N.V.

THREE-DIMENSIONAL POROUS STRUCTURE AND METHOD FOR PRODUCING IT

Número de solicitud/publicación: 20 23076799
Fecha: 2023-09-27
Solicitante(s): C2CAT BV