Gene-edited T cells combating IgA Nephropathy. A blueprint approach for safe & efficient genome editing of T cells to sustainably combat several immune diseases and cancers related to B-cell pathology

Project Information

geneTIGA

Grant agreement ID: 101057438

DOI

10.3030/101057438

EC signature date 23 May 2022

Start date 1 July 2022

End date 30 June 2026

Funded under

• Health

Total cost

€ 6 393 736,00

EU contribution

€ 6 393 734,00

Coordinated by

CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Germany

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Deliverables

Websites, patent fillings, videos etc. (1)

Project website and project visual identity

Definition of the project visual identity, design and development of project website

Publications

Peer reviewed articles (9)

Integration of <i>ζ</i>-deficient CARs into the <i>CD3</i> <i>ζ</i> gene conveys potent cytotoxicity in T and NK cells

Author(s): Jonas Kath, Clemens Franke, Vanessa Drosdek, Weijie Du, Viktor Glaser, Carla Fuster-Garcia, Maik Stein, Tatiana Zittel, Sarah Schulenberg, Caroline E. Porter, Lena Andersch, Annette Künkele, Joshua Alcaniz, Jens Hoffmann, Hinrich Abken, Mohamed Abou-el-Enein, Axel Pruß, Masataka Suzuki, Toni Cathomen, Renata Stripecke, Hans-Dieter Volk, Petra Reinke, Michael Schmueck-Henneresse, Dimitrios L. Wagner
Published in: Blood, Issue 143, 2024, ISSN 0006-4971
Publisher: American Society of Hematology
DOI: 10.1182/BLOOD.2023020973

Cell-Based Models of ‘Cytokine Release Syndrome’ Endorse CD40L and Granulocyte–Macrophage Colony-Stimulating Factor Knockout in Chimeric Antigen Receptor T Cells as Mitigation Strategy

Author(s): Ala Dibas, Manuel Rhiel, Vidisha Bhavesh Patel, Geoffroy Andrieux, Melanie Boerries, Tatjana I. Cornu, Jamal Alzubi, Toni Cathomen
Published in: Cells, Issue 12, 2025, ISSN 2073-4409
Publisher: MDPI AG
DOI: 10.3390/CELLS12212581

Long-term in vitro maintenance of plasma cells in a hydrogel-enclosed human bone marrow microphysiological 3D model system

Author(s): Stefania Martini, Norman Michael Drzeniek, Regina Stark, Matthias Reiner Kollert, Weijie Du, Simon Reinke, Melanie Ort, Sebastian Hardt, Iuliia Kotko, Jonas Kath, Stephan Schlickeiser, Sven Geißler, Dimitrios Laurin Wagner, Anna-Catharina Krebs, Hans-Dieter Volk
Published in: Biofabrication, Issue 16, 2024, ISSN 1758-5082
Publisher: IOP Publishing
DOI: 10.1088/1758-5090/AD5DFE

Multiscale topology classifies cells in subcellular spatial transcriptomics

Author(s): Katherine Benjamin, Aneesha Bhandari, Jessica D. Kepple, Rui Qi, Zhouchun Shang, Yanan Xing, Yanru An, Nannan Zhang, Yong Hou, Tanya L. Crockford, Oliver McCallion, Fadi Issa, Joanna Hester, Ulrike Tillmann, Heather A. Harrington, Katherine R. Bull
Published in: Nature, Issue 630, 2024, ISSN 0028-0836
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41586-024-07563-1

Single-stranded HDR templates with truncated Cas12a-binding sequences improve knock-in efficiencies in primary human T cells

Author(s): Ana-Maria Nitulescu, Weijie Du, Viktor Glaser, Jonas Kath, Eric J. Aird, Grégoire Cullot, Robert Greensmith, Nanna Steengaard Mikkelsen, Maik Stein, Rasmus O. Bak, Michael Kaminski, Jacob E. Corn, Dimitrios L. Wagner
Published in: Molecular Therapy Nucleic Acids, Issue 36, 2025, ISSN 2162-2531
Publisher: Elsevier BV
DOI: 10.1016/J.OMTN.2025.102568

Gene editing of CD3 epsilon to redirect regulatory T cells for adoptive T cell transfer

Author(s): Weijie Du, Fatih Noyan, Oliver McCallion, Vanessa Drosdek, Jonas Kath, Viktor Glaser, Carla Fuster-Garcia, Mingxing Yang, Maik Stein, Clemens Franke, Yaolin Pu, Olaf Weber, Julia K. Polansky, Toni Cathomen, Elmar Jaeckel, Joanna Hester, Fadi Issa, Hans-Dieter Volk, Michael Schmueck-Henneresse, Petra Reinke, Dimitrios L. Wagner
Published in: Molecular Therapy, Issue 33, 2025, ISSN 1525-0016
Publisher: Elsevier BV
DOI: 10.1016/J.YMTHE.2025.01.045

Genome editing with the HDR-enhancing DNA-PKcs inhibitor AZD7648 causes large-scale genomic alterations

Author(s): Grégoire Cullot, Eric J. Aird, Moritz F. Schlapansky, Charles D. Yeh, Lilly van de Venn, Iryna Vykhlyantseva, Susanne Kreutzer, Dominic Mailänder, Bohdan Lewków, Julia Klermund, Christian Montellese, Martina Biserni, Florian Aeschimann, Cédric Vonarburg, Helmuth Gehart, Toni Cathomen, Jacob E. Corn
Published in: Nature Biotechnology, 2024, ISSN 1087-0156
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41587-024-02488-6

Integration of ζ-deficient CARs into the CD3-zeta gene conveys potent cytotoxicity in T and NK cells

Author(s): Kath J, Franke C, Drosdek V, Du W, Glaser V, Fuster-Garcia C, Stein M, Zittel T, Schulenberg S, Porter CE, Andersch L, Künkele A, Alcaniz J, Hoffmann J, Abken H, Abou-el-Enein M, Pruß A, Suzuki M, Cathomen T, Stripecke R, Volk HD, Reinke P, Schmueck-Henne
Published in: BioRxiv, 2023, ISSN 2692-8205
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2023.11.10.565518

New dawn of cellular therapies in autoimmune diseases

Author(s): Wagner DL, Ostendorf L
Published in: Molecular Therapy Methods & Clinical Development, 2023, ISSN 2329-0501
Publisher: Cell Press
DOI: 10.1016/j.omtm.2023.101141