Gene-edited T cells combating IgA Nephropathy. A blueprint approach for safe & efficient genome editing of T cells to sustainably combat several immune diseases and cancers related to B-cell pathology

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Integration of ζ-deficient CARs into the CD3-zeta gene conveys potent cytotoxicity in T and NK cells

Auteurs: Kath J, Franke C, Drosdek V, Du W, Glaser V, Fuster-Garcia C, Stein M, Zittel T, Schulenberg S, Porter CE, Andersch L, Künkele A, Alcaniz J, Hoffmann J, Abken H, Abou-el-Enein M, Pruß A, Suzuki M, Cathomen T, Stripecke R, Volk HD, Reinke P, Schmueck-Henne
Publié dans: BioRxiv, 2023, ISSN 2692-8205
Éditeur: Cold Spring Harbor Laboratory
DOI: 10.1101/2023.11.10.565518

New dawn of cellular therapies in autoimmune diseases

Auteurs: Wagner DL, Ostendorf L
Publié dans: Molecular Therapy Methods & Clinical Development, 2023, ISSN 2329-0501
Éditeur: Cell Press
DOI: 10.1016/j.omtm.2023.101141

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