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Telemonitoring of home dialysis utilizing a smart biomimetic arteriovenous graft

Objective

Clinical need: 10% of the population worldwide is affected by chronic kidney disease (CKD) and millions die each year because they do not have access to treatment. Giving global shortage of kidney donors, the vast majority of patients rely on hemodialysis (HD). Over 2.6M people worldwide currently receive HD to stay alive, yet this number may only represent 10% of people needing treatment.
Solution: Up to 70% of current arteriovenous grafts (AVG) fail in the first year after implantation. This is primarily due to thrombosis, luminal scar formation, and infection. In our ground-breaking new AVG, biomimicking zwitterions prevent thrombosis, drug delivery prevents scar formation and infection, and an ECM coating ensures fast tissue integration allowing early HD.
Smart: TELEGRAFT comprises two diagnostic tools to monitor and prevent device complication. Pressure transmitters are used to monitor blood flow and optical sensors to detect inflammation and infections. The data is processed by AI machine learning models and displayed in an easy to understand dashboard for healthcare professionals. The data allows online telemonitoring and consultations by remote healthcare professionals. This makes home dialysis safe for patients, even in areas with poor infrastructure, where patients live far from HD clinics.
Surgical implantation: The TELEGRAFT system will be demonstrated in an operational environment through a 2-stage randomized clinical trial enrolling 60 patients at 5 hospitals across Europe and through a home HD field study.
Resource constrained setting: (1) In low and middle income countries, TELEGRAFT will substitute complicated and expensive kidney transplantation and allow simpler and cheap implantation of AVG for HD. (2) TELEGRAFT is the only solution with diagnostic tools allowing real-time online detection and remote monitoring of complications and device failure. This allows transition from HD at the hospital to the resource constrained home setting.

Coordinator

SYDDANSK UNIVERSITET
Net EU contribution
€ 445 322,00
Address
Campusvej 55
5230 Odense M
Denmark

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Region
Danmark Syddanmark Fyn
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,50

Participants (10)

VERIGRAFT AB
Sweden
Net EU contribution
€ 543 550,00
Address
Arvid Wallgrens Backe 20
413 46 Goteborg

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Södra Sverige Västsverige Västra Götalands län
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 232 950,00
BIOMODICS APS
Denmark
Net EU contribution
€ 1 316 612,50
Address
Stengards Alle 31 A
2800 Kgs Lyngby

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Danmark Hovedstaden Københavns omegn
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 564 262,50
LEIBNIZ-INSTITUT FUER PHOTONISCHE TECHNOLOGIEN E.V.
Germany
Net EU contribution
€ 709 000,00
Address
Albert Einstein Strasse 9
07745 Jena

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Region
Thüringen Thüringen Jena, Kreisfreie Stadt
Activity type
Research Organisations
Other funding
€ 0,00
REGION SYDDANMARK
Denmark
Net EU contribution
€ 739 452,00
Address
Damhaven 12
7100 Vejle

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Region
Danmark Syddanmark Sydjylland
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Other funding
€ 0,00
BMD SOFTWARE LDA
Portugal
Net EU contribution
€ 346 500,00
Address
Pci Parque De Ciencia E Inovacao Via Do Conhecimento Edif Central
3830-352 Ilhavo

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Continente Centro (PT) Região de Aveiro
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 148 500,00
VIESOJI ISTAIGA VILNIAUS UNIVERSITETO LIGONINE SANTAROS KLINIKOS
Lithuania
Net EU contribution
€ 40 118,00
Address
Santariskiu G 2
LT-08661 Vilnius

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Region
Lietuva Sostinės regionas Vilniaus apskritis
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Other funding
€ 0,75
KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN
Germany
Net EU contribution
€ 76 975,00
Address
Ismaninger Strasse 22
81675 Muenchen

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Region
Bayern Oberbayern München, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
Servicio Vasco de Salud Osakidetza
Spain
Net EU contribution
€ 9 673,75
Address
Alava 45
01006 Vitoria-gasteiz

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Region
Noreste País Vasco Araba/Álava
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Other funding
€ 0,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

ASOCIACION INSTITUTO DE INVESTIGACION SANITARIA BIOCRUCES BIZKAIA
Spain
Net EU contribution
€ 47 543,75
Address
Plaza De Cruces Sn
48903 Barakaldo Bizkaia

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Region
Noreste País Vasco Bizkaia
Activity type
Research Organisations
Other funding
€ 0,00
REGION STOCKHOLM
Sweden
Net EU contribution
€ 77 775,00
Address
Hantverkargatan 45
104 22 Stockholm

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Region
Östra Sverige Stockholm Stockholms län
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Other funding
€ 0,00

Partners (1)

ASTON UNIVERSITY
United Kingdom
Net EU contribution
No data
Address
Aston Triangle
B4 7ET Birmingham

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Region
West Midlands (England) West Midlands Birmingham
Activity type
Higher or Secondary Education Establishments
Other funding
No data