Descrizione del progetto
L’emodialisi diventa intelligente
L’emodialisi è un trattamento per l’insufficienza renale che depura il sangue tramite un macchinario esterno noto come fegato artificiale. Potrebbe avere bisogno dell’inserimento chirurgico di innesti arterovenosi per accedere al sistema circolatorio. Tuttavia, la gran parte degli innesti risulta inefficace a causa dell’insorgenza di trombosi o infezioni. Il progetto TELEGRAFT, finanziato dall’UE, propone di sviluppare un innesto arterovenoso intelligente che, tramite biomimesi e proprietà di eluizione dei farmaci, riduce al minimo il rischio di trombosi e infezioni, permettendo al contempo il monitoraggio del flusso sanguigno e il rilevamento precoce di infiammazioni e infezioni. In sostanza, funge da sistema di telemonitoraggio al fine di fornire una prevenzione tempestiva e mininvasiva di complicazioni gravi. Tale innovazione offre una soluzione promettente per pazienti che non dispongono di un accesso diretto alle infrastrutture di emodialisi.
Obiettivo
Clinical need: 10% of the population worldwide is affected by chronic kidney disease (CKD) and millions die each year because they do not have access to treatment. Giving global shortage of kidney donors, the vast majority of patients rely on hemodialysis (HD). Over 2.6M people worldwide currently receive HD to stay alive, yet this number may only represent 10% of people needing treatment.
Solution: Up to 70% of current arteriovenous grafts (AVG) fail in the first year after implantation. This is primarily due to thrombosis, luminal scar formation, and infection. In our ground-breaking new AVG, biomimicking zwitterions prevent thrombosis, drug delivery prevents scar formation and infection, and an ECM coating ensures fast tissue integration allowing early HD.
Smart: TELEGRAFT comprises two diagnostic tools to monitor and prevent device complication. Pressure transmitters are used to monitor blood flow and optical sensors to detect inflammation and infections. The data is processed by AI machine learning models and displayed in an easy to understand dashboard for healthcare professionals. The data allows online telemonitoring and consultations by remote healthcare professionals. This makes home dialysis safe for patients, even in areas with poor infrastructure, where patients live far from HD clinics.
Surgical implantation: The TELEGRAFT system will be demonstrated in an operational environment through a 2-stage randomized clinical trial enrolling 60 patients at 5 hospitals across Europe and through a home HD field study.
Resource constrained setting: (1) In low and middle income countries, TELEGRAFT will substitute complicated and expensive kidney transplantation and allow simpler and cheap implantation of AVG for HD. (2) TELEGRAFT is the only solution with diagnostic tools allowing real-time online detection and remote monitoring of complications and device failure. This allows transition from HD at the hospital to the resource constrained home setting.
Campo scientifico
- medical and health sciencesclinical medicineangiologyvascular diseases
- engineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringsensorsoptical sensors
- medical and health sciencesclinical medicinetransplantation
- natural sciencescomputer and information sciencesartificial intelligencemachine learning
- medical and health sciencesclinical medicinenephrologykidney diseases
Parole chiave
Programma(i)
Meccanismo di finanziamento
HORIZON-IA - HORIZON Innovation ActionsCoordinatore
5230 Odense M
Danimarca