Description du projet
Pour une hémodialyse intelligente
L’hémodialyse est un traitement de l’insuffisance rénale qui consiste à purifier le sang à l’aide d’un dispositif externe appelé rein artificiel. Elle peut nécessiter des greffes artério-veineuses placées chirurgicalement afin de faciliter l’accès au système sanguin. Cependant, la plupart de ces greffes échouent en raison d’une thrombose ou d’une infection. Le projet TELEGRAFT, financé par l’UE, se propose de mettre au point une greffe artério-veineuse intelligente qui, grâce au biomimétisme et aux propriétés d’élution des médicaments, minimiserait le risque de thrombose et d’infection en permettant de surveiller le flux sanguin et de détecter précocement les inflammations et les infections. Elle servirait principalement de système de télésurveillance afin de faciliter une prévention précoce et peu invasive des complications graves. Cette innovation offre une solution prometteuse pour les patients qui ne profitent pas d’un accès direct aux infrastructures d’hémodialyse.
Objectif
Clinical need: 10% of the population worldwide is affected by chronic kidney disease (CKD) and millions die each year because they do not have access to treatment. Giving global shortage of kidney donors, the vast majority of patients rely on hemodialysis (HD). Over 2.6M people worldwide currently receive HD to stay alive, yet this number may only represent 10% of people needing treatment.
Solution: Up to 70% of current arteriovenous grafts (AVG) fail in the first year after implantation. This is primarily due to thrombosis, luminal scar formation, and infection. In our ground-breaking new AVG, biomimicking zwitterions prevent thrombosis, drug delivery prevents scar formation and infection, and an ECM coating ensures fast tissue integration allowing early HD.
Smart: TELEGRAFT comprises two diagnostic tools to monitor and prevent device complication. Pressure transmitters are used to monitor blood flow and optical sensors to detect inflammation and infections. The data is processed by AI machine learning models and displayed in an easy to understand dashboard for healthcare professionals. The data allows online telemonitoring and consultations by remote healthcare professionals. This makes home dialysis safe for patients, even in areas with poor infrastructure, where patients live far from HD clinics.
Surgical implantation: The TELEGRAFT system will be demonstrated in an operational environment through a 2-stage randomized clinical trial enrolling 60 patients at 5 hospitals across Europe and through a home HD field study.
Resource constrained setting: (1) In low and middle income countries, TELEGRAFT will substitute complicated and expensive kidney transplantation and allow simpler and cheap implantation of AVG for HD. (2) TELEGRAFT is the only solution with diagnostic tools allowing real-time online detection and remote monitoring of complications and device failure. This allows transition from HD at the hospital to the resource constrained home setting.
Champ scientifique
- medical and health sciencesclinical medicineangiologyvascular diseases
- engineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringsensorsoptical sensors
- medical and health sciencesclinical medicinetransplantation
- natural sciencescomputer and information sciencesartificial intelligencemachine learning
- medical and health sciencesclinical medicinenephrologykidney diseases
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Programme(s)
Régime de financement
HORIZON-IA - HORIZON Innovation ActionsCoordinateur
5230 Odense M
Danemark