A PeRsOnalized Prevention roadmap for the future HEalThcare

Informations projet

PROPHET

N° de convention de subvention: 101057721

DOI

10.3030/101057721

Date de signature de la CE 20 Mai 2022

Date de début 1 Septembre 2022

Date de fin 31 Août 2026

Financé au titre de

• Health

Coût total

€ 2 812 437,50

Contribution de l’UE

€ 2 812 437,00

Coordonné par

UNIVERSITA CATTOLICA DEL SACRO CUORE
Italy

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (10)

Report on data management and infrastructure requirements to bring research advances into Health Systems, outlining challenges and best practices

A summary of the data management needs, in alignment with the B1MG

List of process and outcome indicators for the evaluation of the clinical utility of personalized preventive approaches

Report with the list process and outcome indicators needed to evaluate the clinical utility of personalized preventive approaches

Report on biomarkers and digital technologies for risk prediction

A summary of the state of the art, opportunities & main gaps in biomarkers availability for precision prevention in the three selected areas & their integration with digital technologies for risk prediction and stratification.

Concept Paper on SRIA

A Concept Paper that include the preliminary concept towards SRIA.

Stakeholder Analysis

Analysis with stakeholder mapping and evaluation, required to the work related to D1.2

Report on clinical usefulness of biomarkers for personalized disease prevention

A summary of the evidence mapping on clinical usefulness of available biomarkers for precision prevention in the three selected areas.

Report on critical factors for the successful adoption of Personalized Prevention approaches by healthcare systems

A summary of findings from the literature mapping and survey to end users

Private sector and personal preventive information

Report on the role of the private sector, especially Direct-to-Consumer (DTC) companies, to produce personal preventive information and measures.

Report on current practices of citizens', patients', health professionals and policy makers engagement in Personalized Prevention and their gaps/bottleneck

A summary of the evidence mapping and desk research results.

Report on existing Research Programmes in the field of Personalized Prevention

A summary on existing Research programmes with a focus on the main obstacles in implementing and advancing research in the field of Personalized Prevention.

Other (1)

Stakeholder Platform

Release of the Forum, including explanation of roles, responsibilities, expectations, modus operandi

Websites, patent fillings, videos etc. (1)

Project Website

Website of the PROPHET project

Publications

Peer reviewed articles (13)

The current landscape of personalised preventive approaches for non-communicable diseases: A scoping review

Auteurs: Sara Farina, Tommaso Osti, Luigi Russo, Alessandra Maio, Nicolò Scarsi, Cosimo Savoia, Abdelrahman Taha, Leonardo Villani, Roberta Pastorino, Stefania Boccia
Publié dans: PLOS ONE, Numéro 20, 2025, ISSN 1932-6203
Éditeur: Public Library of Science (PLoS)
DOI: 10.1371/JOURNAL.PONE.0317379

Biomarkers for personalised prevention of chronic diseases: a common protocol for three rapid scoping reviews

Auteurs: E Plans-Beriso, C Babb-de-Villiers, D Petrova, C Barahona-López, P Diez-Echave, O R Hernández, N F Fernández-Martínez, H Turner, E García-Ovejero, O Craciun, P Fernández-Navarro, N Fernández-Larrea, E García-Esquinas, I Kuhn, V Jiménez-Planet, V Moreno, F Rodríguez-Artalejo, M J Sánchez, M Pollan-Santamaria, L Blackburn, M Kroese, B Pérez-Gómez
Publié dans: Systematic Reviews, Numéro 13, 2024, ISSN 2046-4053
Éditeur: Springer Science and Business Media LLC
DOI: 10.1186/S13643-024-02554-9

Scanning the horizon of personalized prevention research: an overview of ongoing European funded initiatives

Auteurs: Alessandra Maio, Sara Farina, Tommaso Osti, Salvatore Di Grande, Roberta Pastorino, Stefania Boccia
Publié dans: Frontiers in Public Health, Numéro 13, 2025, ISSN 2296-2565
Éditeur: Frontiers Media SA
DOI: 10.3389/FPUBH.2025.1561328

Indicators of the clinical utility of genetic or genomic testing: a scoping review

Auteurs: A Valz Gris, A Pezzullo, T Diego, M Porcelli, M Di Pumpo, N Scarsi, null null, S Boccia
Publié dans: European Journal of Public Health, Numéro 34, 2024, ISSN 1101-1262
Éditeur: Oxford University Press (OUP)
DOI: 10.1093/EURPUB/CKAE144.1574

Barriers and facilitators for implementing a pharmacogenetic passport: lessons learned from reusing sequencing data

Auteurs: Anja H. A. Roelofsen, Loes Lindiwe Kreeftenberg, Carla G. van El, Lidewij Henneman, Tessel Rigter, Daoud Sie, Pierre M. Bet, Martina C. Cornel
Publié dans: Pharmacogenomics, Numéro 26, 2025, ISSN 1462-2416
Éditeur: Informa UK Limited
DOI: 10.1080/14622416.2025.2504862

Biomarkers for Personalised Primary or Secondary Prevention in Cardiovascular Diseases: A Rapid Scoping Review

Auteurs: Chantal Babb de Villiers, Elena Plans-Beriso, Chaitanya Erady, Laura Blackburn, Hayley Wilson, Heather Turner, Isla Kuhn, Cristina Barahona-López, Paul Diez-Echave, Orlando Romulo Hernández, Nerea Fernández de Larrea-Baz, Dafina Petrova, Ramon Cierco Jimenez, Pablo Fernández-Navarro, Esther García-Esquinas, Fernando Rodríguez-Artalejo, María José Sánchez, Víctor Moreno, Marina Pollán, Beatriz Perez-Gomez, Mark Kroese
Publié dans: International Journal of Molecular Sciences, Numéro 26, 2025, ISSN 1422-0067
Éditeur: MDPI AG
DOI: 10.3390/IJMS26199346

Sharing behavior and health care utilization following direct-to-consumer genetic testing: a systematic review

Auteurs: Eva Van Steijvoort, Kaatje Goossens, Kenji Demesure, Alexandra Stanczak, Maria Siermann, Pascal Borry
Publié dans: Open Research Europe, Numéro 5, 2025, ISSN 2732-5121
Éditeur: F1000 Research Ltd
DOI: 10.12688/OPENRESEUROPE.19751.1

Engagement of patients and the public in personalised prevention in Europe using genomic information: a scoping review

Auteurs: Loes Lindiwe Kreeftenberg; Loes Lindiwe Kreeftenberg; Lidewij Henneman; Lidewij Henneman; Johannes C. F. Ket; Martina C. Cornel; Martina C. Cornel; Carla G. van El; Carla G. van El
Publié dans: Frontiers in Public Health, 2024, ISSN 2296-2565
Éditeur: Frontiers Media S.A
DOI: 10.3389/FPUBH.2024.1456853

Implementation of genetic tests for disease prevention: challenges in evidence synthesis across clinical utility domains

Auteurs: Angelica Valz Gris, Astrid M Vicente, Stefania Boccia
Publié dans: European Journal of Public Health, Numéro 35, 2025, ISSN 1101-1262
Éditeur: Oxford University Press (OUP)
DOI: 10.1093/EURPUB/CKAF047

The PROPHET project paves the way for personalized prevention in the future healthcare

Auteurs: Roberta Pastorino, Angelo Maria Pezzullo, Tommaso Osti, Roza Adany, Pascal Borry, Floris Barnhoorn, Eva Fadil, Mark Kroese, Andres Metspalu, Beatriz Perez-Gomez, Markus Perola, Daniela Quaggia, Serena Scollen, Mahsa Shabani
Publié dans: European Journal of Cancer Prevention, 2024, ISSN 0959-8278
Éditeur: Wolters Kluwer Health
DOI: 10.1097/CEJ.0000000000000873

Clinician perspectives on policy approaches to genetic risk disclosure in families

Auteurs: Amicia Phillips; Danya F. Vears; Ine Van Hoyweghen; Pascal Borry
Publié dans: Familial Cancer, 2023, ISSN 1573-7292
Éditeur: Springer Nature B.V.
DOI: 10.1007/S10689-024-00375-2

A scoping review of the assessment reports of genetic or genomic tests reveals inconsistent consideration of key dimensions of clinical utility

Auteurs: Angelo Maria Pezzullo, Angelica Valz Gris, Nicolò Scarsi, Diego Maria Tona, Martina Porcelli, Matteo Di Pumpo, Peter Piko, Roza Adany, Pragathy Kannan, Markus Perola, Maria Luis Cardoso, Alexandra Costa, Astrid M. Vicente, Anu Reigo, Mariliis Vaht, Andres Metspalu, Mark Kroese, Roberta Pastorino, Stefania Boccia
Publié dans: Journal of Clinical Epidemiology, Numéro 181, 2025, ISSN 0895-4356
Éditeur: Elsevier BV
DOI: 10.1016/J.JCLINEPI.2025.111729

Lawfulness in secondary use of health data

Auteurs: Mahsa Shabani; Sami Yilmaz
Publié dans: Technology and Regulation, Vol 2022 (2022), 2022, ISSN 2666-139X
Éditeur: Open Press TiU
DOI: 10.26116/TECHREG.2022.013