Project description
Novel platform for multiparametric assessment of drug-related cardiotoxicity
Drug-related cardiotoxicity is the major cause of the failure or withdrawal of drugs from the market. Currently, cardiotoxicity can’t be assessed monitoring both cardiac action potentials whereby the heart beats through electrical impulses (functional toxicity) and damage to the heart’s morphology (structural toxicity) in a biological sample. This hinders comprehensive toxicity assessments. The EIC-funded SiMulTox project, using proprietary laser-based technology, aims to develop a novel platform for the simultaneous detection of both types of toxicity. The in vitro platform will combine transmembrane action potential recordings and live-cell fluorescence imaging in the same cardiac cell culture. Importantly, it will enable long-term tests for chronic toxic effect assessment. The final project objective is commercialisation of this novel platform to advance in vitro cardiotoxicity assessment.
Objective
Cardiac drug-related adverse effects have been the major causes for the failure or withdrawal of drugs from the market. With a growing global market, cardiotoxicity still remains a bottleneck in the chain of drug development. Despite the large investments in drug discovery and development, the number of approved drugs has been declining.
Current in-vitro technologies assess functional cardiotoxicity relying on short-term electrophysiological recordings (detection of cardiac Action Potentials, AP). However, drug toxic effects may manifest themselves in other ways such as morphological alterations, toxic chemical species generation or metabolic dysfunction. These effects are categorized as structural cardiotoxicity.
Presently, functional and structural toxicities cannot be assessed simultaneously on the same cardiac cell culture in long-term experiments. This represents a substantial barrier to a deeper toxicity assessment.
SiMulTox addresses this need with a novel platform for multiparametric detection of cardiac functional and structural toxicity. Starting from the unique laser-based technology of Foresee Biosystems, SiMulTox aims at developing an in-vitro platform that exploits a combinatorial approach of AP recordings and live-cell fluorescence imaging of the same cardiac cell culture. More importantly, it will provide these capabilities in extremely long tests (more than 1 month) that enable the assessment of chronic toxic effects.
The final objective is the commercialization of a platform that will reshape the market of in-vitro cardiotoxicity assessment. The product will generate high demand for equipment in the markets of cardiac physiology, safety pharmacology, and drug development. In perspective, SiMulTox will pave the way also to new products for assessing functional and structural neurotoxicities simultaneously, allowing Foresee Biosystems to expand substantially its target market.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine physiology
- medical and health sciences basic medicine pharmacology and pharmacy
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.3.1 - The European Innovation Council (EIC)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-EIC-2021-TRANSITIONOPEN-01
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16121 Genova
Italy
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