Understanding the individual host response against Hepatitis D Virus to develop a personalized approach for the management of hepatitis D

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Plan for dissemination and exploitation of results (M6)

A strategic plan for the dissemination and exploitation of results is available.

Project website, brochure, logo, Twitter account

Project website will be launched.Information material as a brochure will be available.A consortium logo will be ready.Social media accounts will be implemented.

Established of fine-needle aspiration protocol and training of physicians at all clinical site

SOP document; training workshop for trial staff

Data Management Plan

The plan outlines all the data that will be collected and generated during the project, how it will be created, stored and backed-up, who owns it and who is responsible for the different data and which data will be preserved and shared, according to the participation of the project in the Open Data Research Pilot.

A general risk assessment tool/platform

A software platform with a website interface that can be used for data risk assessment for all partners in the project

Final version of study protocol as approved by the regulator(s) / ethics committee(s) and trial registration

Study protocol submitted to a journal, registration on a website

Security and privacy risk assessment report

A scientific report/paper about the security and privacy risk assessment, including threat model, method, and results

Promotional literature (e.g. leaflets, slide deck) with information about the project to be used as a communication tool at scientific events and workshops attended by consortium members

Additional promotional literature (e.g. leaflets, slide deck) with information about the project to be used as a communication tool at scientific events and workshops attended by consortium members are designed and available

General project Management Plan

Project internal management plan, elaborating on relevant internal procedures and responsibilities, rules and guidelines, and clarifying baseline EC requirements for effective and efficient collaboration, communication and dissemination - guidelines and templates for the execution of the project included.

Finalization of the study protocol of the bulevirtide stop trial including ethics submission

Study protocol, proof of ethic submission

Clinical protocol and establishment of the redcap electronic case-report form

Protocol document, redcap ECRF-form online available for HDV 750 cohort.

New attack methods and their implementation

A document describing method/algorithms on the potential attacks for the system, and their software implementation

D-SOLVE academy established

The D-SOLVE academy will be founded to enable exchange between D-SOLVE centers. The concept of the academy will be agreed on and be implemented at M12.

Implementation of an Ethics & Scientific Advisory Board (ESAB), a Data Safety Monitoring Board (in cooperation with WP6) for the clinical trial (DSMB), and an Innovation Management Board (IMB)
Attack evaluation results

A document summarizing the experimental evaluation for the attacks from D6.2

Publications

Phase 2 Randomised Study of Bulevirtide as Monotherapy or Combined With Peg‐<scp>IFNα</scp>‐2a as Treatment for Chronic Hepatitis Delta

Auteurs: Pietro Lampertico, Pavel O. Bogomolov, Vladimir Chulanov, Tatiana Stepanova, Viacheslav Morozov, Lena Allweiss, Maura Dandri, Jürgen Burhenne, Antje Blank, Sandra Ciesek, Carina Elsner, Ulf Dittmer, Qi An, Dmitry Manuilov, Ben L. Da, John F. Flaherty, Stephan Urban, Heiner Wedemeyer
Publié dans: Liver International, Numéro 45, 2025, ISSN 1478-3223
Éditeur: Wiley
DOI: 10.1111/LIV.70008

Auteurs: Giannone F, Slovic N, Pessaux P, Schuster C, Baumert TF, Lupberger J.
Publié dans: Front. Oncol, 2023, ISSN 2234-943X
Éditeur: Frontiers Media S. A.
DOI: 10.3389/fonc.2023.1267870

High Rates of Advanced Chronic Liver Disease in Patients With Chronic Hepatitis D Virus Infection in Uzbekistan

Auteurs: Malika E. Khodjaeva, Aziza S. Khikmatullaeva, Nargiz S. Ibadullaeva, Gulnara K. Khudaykulova, Munisa M. Ilyasova, Kamila U. Eshbayeva, Dildorakhon N. Abdurakhmanova, Helenie Kefalakes, Petra Huber, Michael J. Gebel, Erkin I. Musabaev, Heiner Wedemeyer, Lisa Sandmann
Publié dans: Liver International, Numéro 46, 2026, ISSN 1478-3223
Éditeur: Wiley
DOI: 10.1111/LIV.70799

Diabetes, male sex, low levels of HBsAg, HDV RNA, and ALT predict spontaneous HDV suppression in chronic hepatitis D

Auteurs: Habiba Kamal, Ganbolor Jargalsaikhan, Sanjaasuren Enkhtaivan, Karin Lindahl, Bekhbold Dashtseren, Oyungerel Lkhagva-Ochir, Tuvshinjargal Ulziibadrakh, Andreas Bungert, Elisabetta Degasperi, Pietro Lampertico, Heiner Wedemeyer, Naranjargal B. Dashdorj, Soo Aleman
Publié dans: Hepatology, 2026, ISSN 0270-9139
Éditeur: Ovid Technologies (Wolters Kluwer Health)
DOI: 10.1097/HEP.0000000000001786

Differential HBV RNA and HBcrAg patterns in untreated patients with chronic hepatitis delta

Auteurs: Elisabetta Degasperi, Caroline Scholtes, Barbara Testoni, Sara Uceda Renteria, Maria Paola Anolli, Caroline Charre, Floriana Facchetti, Marie-Laure Plissonnier, Dana Sambarino, Riccardo Perbellini, Sara Monico, Annapaola Callegaro, Ester García-Pras, Sabela Lens, Maria Francesca Cortese, Xavier Forns, Sofía Pérez-del-Pulgar, Marintha Heil, Massimo Levrero, Fabien Zoulim, Pietro Lampertico
Publié dans: Journal of Hepatology, Numéro 82, 2025, ISSN 0168-8278
Éditeur: Elsevier BV
DOI: 10.1016/J.JHEP.2024.11.051

Hepatitis D virus—still the devil!

Auteurs: Anika Wranke, Heiner Wedemeyer
Publié dans: Hepatology, Numéro 81, 2025, ISSN 0270-9139
Éditeur: Ovid Technologies (Wolters Kluwer Health)
DOI: 10.1097/HEP.0000000000001144

Sodium taurocholate cotransporting polypeptide (NTCP) polymorphisms may influence HDV RNA load and early response to bulevirtide

Auteurs: Pierluigi Toniutto, Edmondo Falleti, Sara Cmet, Annarosa Cussigh, Elisabetta Degasperi, Maria Paola Anolli, Dana Sambarino, Floriana Facchetti, Marta Borghi, Riccardo Perbellini, Sara Monico, Pietro Lampertico
Publié dans: Journal of Hepatology, Numéro 81, 2025, ISSN 0168-8278
Éditeur: Elsevier BV
DOI: 10.1016/J.JHEP.2024.06.013

Droplet Digital PCR: A Powerful Tool for Accurate Quantification of Hepatitis D Virus RNA Levels and Verification of Detection Limits

Auteurs: L. Sandmann, L. Windzio, B. Bremer, S. Falak, J. Beheim‐Schwarzbach, A. Kummrow, M. Cornberg, H. Wedemeyer, B. Maasoumy, E. Valiente
Publié dans: Journal of Viral Hepatitis, Numéro 32, 2025, ISSN 1352-0504
Éditeur: Wiley
DOI: 10.1111/JVH.70036

Prevalence of chronic viral hepatitis B, D among Mongol migrants in Sweden compared to a sex- and age-matched native Mongol cohort

Auteurs: Delgersaikhan Zulkhuu, Habiba Kamal, Sanjaasuren Enkhtaivan, Ochirmaa Narantsogt, Ganbolor Jargalsaikhan, Munguntsetseg Batkhuu, Byambasuren Ochirsum, Marcus Ahl, Karin Lindahl, Michael Ingre, Natalie Stiglund, Alexandros Petropoulos, Gustaf Sandh, Niklas K. Björkström, Sonja Saario, Susanne Cederberg, Annika Olsson, Anna Wange Baye, Ihssan Derdabi, Desideria Georgos, Andreas S. Bungert, Nara Bungert Dashdorj, N. D. Dashdorj Onom, Soo Aleman
Publié dans: BMC Infectious Diseases, Numéro 26, 2026, ISSN 1471-2334
Éditeur: Springer Science and Business Media LLC
DOI: 10.1186/S12879-025-12506-W

144 Weeks of bulevirtide monotherapy for chronic hepatitis D: Final and post-treatment results from a phase III randomized trial

Auteurs: Heiner Wedemeyer, Soo Aleman, Antje Blank, Pietro Andreone, Pavel Bogomolov, Vladimir Chulanov, Nina Mamonova, Natalia Geyvandova, Viacheslav Morozov, Olga Sagalova, Tatiana Stepanova, Annemarie Berger, Sandra Ciesek, Amos Lichtman, Dmitry Manuilov, Renee-Claude Mercier, Sarah Arterburn, Florence Christian-Cox, Steve Tseng, Anu Osinusi, Julian Schulze zur Wiesch, Markus Cornberg, Stefan Zeuzem, Maurizia Rossana Brunetto, Pietro Lampertico
Publié dans: Journal of Hepatology, Numéro 85, 2026, ISSN 0168-8278
Éditeur: Elsevier BV
DOI: 10.1016/J.JHEP.2026.03.046

Antiviral therapy for chronic hepatitis delta: new insights from clinical trials and real-life studies

Auteurs: Pietro Lampertico, Maria Paola Anolli, Dominique Roulot, Heiner Wedemeyer
Publié dans: Gut, Numéro 74, 2025, ISSN 0017-5749
Éditeur: BMJ
DOI: 10.1136/GUTJNL-2024-332597

Validation of Baveno VII criteria and other non-invasive diagnostic algorithms for clinically significant portal hypertension in hepatitis delta

Auteurs: Jachs M, Sandmann L, Hartl L, Tergast T, Schwarz M, Bauer DJM, Balcar L, Ehrenbauer A, Hofer BS, Cornberg M, Lenzen H, Deterding K, Trauner M, Mandorfer M, Wedemeyer H, Reiberger T, Maasoumy B.
Publié dans: Journal of Hepatology, 2024, ISSN 1600-0641
Éditeur: Journal of Hepatology
DOI: 10.1016/j.jhep.2024.03.005

TIGIT expression on natural killer cell subsets is an early indicator of alleviating liver inflammation following bulevirtide treatment in chronic hepatitis D

Auteurs: Po-Chun Chen, Katja Deterding, Sophie Anna Engelskircher, Kerstin Port, Lisa Sandmann, Athira Chakkadath, Tijana Ristic, Qingyu Wu, Birgit Bremer, Anke R.M. Kraft, Markus Cornberg, Albert Heim, Helenie Kefalakes, Niklas K. Björkström, Norman Woller, Heiner Wedemeyer
Publié dans: Hepatology, 2025, ISSN 0270-9139
Éditeur: Ovid Technologies (Wolters Kluwer Health)
DOI: 10.1097/HEP.0000000000001238

Comparing methods for plasma HDV RNA quantification in bulevirtide-treated and untreated patients with HDV

Auteurs: Maria Paola Anolli, Sara Uceda Renteria, Elisabetta Degasperi, Floriana Facchetti, Dana Sambarino, Marta Borghi, Riccardo Perbellini, Roberta Soffredini, Sara Monico, Annapaola Callegaro, Pietro Lampertico
Publié dans: JHEP Reports, Numéro 7, 2025, ISSN 2589-5559
Éditeur: Elsevier BV
DOI: 10.1016/J.JHEPR.2024.101299

Liver stiffness measurement as a noninvasive method for the diagnosis of liver cirrhosis in patients with chronic hepatitis D virus infection.

Auteurs: Sandmann L, Degasperi E, Port K, Aleman S, Wallin JJ, Manuilov D, Da BL, Cornberg M, Lampertico P, Maasoumy B, Wedemeyer H, Deterding K
Publié dans: Aliment Pharmacol Ther, 2024, ISSN 1365-2036
Éditeur: Aliment Pharmacol Ther
DOI: 10.1111/apt.17878

Hepatitis D Virus Infection: Pathophysiology, Epidemiology and Treatment. Report From the Third Delta Cure Meeting 2024

Auteurs: Elisabetta Degasperi, Lisa Sandmann, Heiner Wedemeyer, Pietro Lampertico, null null
Publié dans: Liver International, Numéro 45, 2025, ISSN 1478-3223
Éditeur: Wiley
DOI: 10.1111/LIV.70189

Memories of Stress: The Imprinted Cancer Risk After HCV Cure

Auteurs: Lupberger, Joachim; Baumert, Thomas F.
Publié dans: Cellular and Molecular Gastroenterology and Hepatology, 2023, ISSN 2352-345X
Éditeur: Elsevier Inc.
DOI: 10.1016/j.jcmgh.2023.05.006

Bile acid increase during bulevirtide treatment of hepatitis D is not associated with a decline in HDV RNA

Auteurs: Deterding K, Xu C, Port K, Dietz-Fricke C, Xun J, Maasoumy B, Cornberg M, Wedemeyer H.
Publié dans: J Viral Hepat., 2023, ISSN 1352-0504
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/jvh.13831.

"Antiviral Therapy of Chronic Hepatitis D Virus Infection - Addendum to the S3 Guideline ""Prophylaxis, Diagnosis and Therapy of Hepatitis B Virus Infection"" of the German Society for Gastroenterology, Digestive and Metabolic Diseases (DGVS)"

Auteurs: Sandmann L, Berg T, Deterding K, Fischer N, Hinrichsen H, Petersen J, Tacke F, Cornberg M
Publié dans: Zeitschrift für Gastroenterologie, 2023, ISSN 0044-2771
Éditeur: Georg Thieme Verlag
DOI: 10.1055/a-2181-3345

siRNA JNJ-73763989 decreases HBsAg and HDV RNA in NA-treated hepatitis D patients but may cause ALT flares

Auteurs: Heiner Wedemeyer, Ed Gane, Kosh Agarwal, Ömer Fehmi Tabak, Xavier Forns, Ulus Salih Akarca, Viacheslav Morozov, Soo Aleman, Maria Buti, Gurdal Yilmaz, Pietro Lampertico, John Jezorwski, Thomas N. Kakuda, Adam Bakala, Nonko Pehlivanov, Thierry Verbinnen, Oliver Lenz, Michael Biermer
Publié dans: Journal of Hepatology, Numéro 85, 2026, ISSN 0168-8278
Éditeur: Elsevier BV
DOI: 10.1016/J.JHEP.2026.05.007

Five‐year follow‐up of 96 weeks peginterferon plus tenofovir disoproxil fumarate in hepatitis D

Auteurs: Olympia E. Anastasiou, Florin A. Caruntu, Manuela G. Curescu, Kendal Yalcin, Ulus S. Akarca, Selim Gürel, Stefan Zeuzem, Andreas Erhardt, Stefan Lüth, George V. Papatheodoridis, Onur Keskin, Kerstin Port, Monica Radu, Mustafa K. Celen, Ramazan Idilman, Benjamin Heidrich, Ingmar Mederacke, Heiko von der Leyen, Julia Kahlhöfer, Maria von Karpowitz, Svenja Hardtke, Markus Cornberg, Cihan Yurdaydin, Heiner Wedemeyer
Publié dans: Liver International, Numéro 44, 2024, ISSN 1478-3223
Éditeur: Wiley
DOI: 10.1111/LIV.15745

Quality of life improves during antiviral therapy with bulevirtide

Auteurs: Julia Carolin Eichholz, Christopher Dietz-Fricke, Simon Kristian Mrowietz, Katja Dinkelborg, Kerstin Port, Heiner Wedemeyer, Katja Deterding
Publié dans: Zeitschrift für Gastroenterologie, Numéro 63, 2025, ISSN 0044-2771
Éditeur: Georg Thieme Verlag KG
DOI: 10.1055/A-2633-6361

Unraveling the genetic susceptibility to HBV-related liver cancer: The role of virus–host immune interactions

Auteurs: Pierre Tonnerre, Yujin Hoshida, Thomas F. Baumert
Publié dans: Hepatology, 2025, ISSN 0270-9139
Éditeur: Ovid Technologies (Wolters Kluwer Health)
DOI: 10.1097/HEP.0000000000001355

Hepatitis delta virus co-infection in patients with hepatocellular carcinoma and people living with HIV in Nigeria

Auteurs: Ijeoma Ifeorah, Birgit Bremer, Yusuf Musa, Julia Kahlhöfer, Oluwatosin Oguntoye, Carey Tishiya, Gatuwa Aglavdawa, Ojonuga Ameh, Yussuf Abdulkadir, Olumuyiwa Ariyo, Manfred Anim, Andre Reinhardt, Albert Heim, Uwem George, Lukman Abdulkareem, Ibrahim Umar Garzali, Heiner Wedemeyer, Lisa Sandmann
Publié dans: BMC Infectious Diseases, Numéro 26, 2026, ISSN 1471-2334
Éditeur: Springer Science and Business Media LLC
DOI: 10.1186/S12879-026-12913-7

An atlas of the human liver diurnal transcriptome and its perturbation by hepatitis C virus infection

Auteurs: Atish Mukherji, Frank Jühling, Yogy Simanjuntak, Emilie Crouchet, Fabio Del Zompo, Yuji Teraoka, Alexandre Haller, Philippe Baltzinger, Soumith Paritala, Fahmida Rasha, Naoto Fujiwara, Cloé Gadenne,
Publié dans: Nature Communications, Numéro 15, 2024, ISSN 2041-1723
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/S41467-024-51698-8

Bulevirtide Monotherapy or in Combination for Chronic Hepatitis Delta: 2025 Update

Auteurs: Pietro Lampertico, Maria Paola Anolli, Katja Steppich, Heiner Wedemeyer
Publié dans: Journal of Viral Hepatitis, Numéro 32, 2025, ISSN 1352-0504
Éditeur: Wiley
DOI: 10.1111/JVH.70056

Hepatitis D virus infection: Pathophysiology, epidemiology and treatment. Report from the first international delta cure meeting 2022

Auteurs: Lampertico P, Degasperi E, Sandmann L, Wedemeyer H; Delta Cure 2022 Working Group
Publié dans: JHEP Reports, 2023, ISSN 2589-5559
Éditeur: JHEP Reports
DOI: 10.1016/j.jhepr.2023.100818

Exploiting the immunopathogenesis of hepatitis D virus infection to develop superior treatment options

Auteurs: Rahaf Albarghash, Carina Jacobsen, Helenie Kefalakes
Publié dans: Antiviral Research, Numéro 250, 2026, ISSN 0166-3542
Éditeur: Elsevier BV
DOI: 10.1016/J.ANTIVIRAL.2026.106416

Clinical long-term outcome of hepatitis D compared to hepatitis B monoinfection.

Auteurs: Wranke A, Heidrich B, Deterding K, Hupa-Breier KL, Kirschner J, Bremer B, Cornberg M, Wedemeyer H.
Publié dans: Hepatol Int., 2023, ISSN 1936-0541
Éditeur: Hepatol Int.
DOI: 10.1007/s12072-023-10575-0

HDV RNA Assays Writing Group at the HBV Forum. HDV RNA assays: Performance characteristics, clinical utility, and challenges

Auteurs: Wedemeyer H, Leus M, Battersby TR, Glenn J, Gordien E, Kamili S, Kapoor H, Kessler HH, Lenz O, Lütgehetmann M, Mixson-Hayden T, Simon CO, Thomson M, Westman G, Miller V, Terrault N, Lampertico P
Publié dans: Hepatology, 2023, ISSN 0270-9139
Éditeur: John Wiley & Sons Inc.
DOI: 10.1097/HEP.0000000000000584

Fate of hepatitis D virus-specific CD8+ T cells during bulevirtide monotherapy in patients with chronic hepatitis delta

Auteurs: Valerie Oberhardt, Elisabetta Degasperi, Michelle Maas, Marta Borghi, Kathrin Heim, Roberta Soffredini, Maria Paola Anolli, Floriana Facchetti, Stéphanie Narguet, Tarik Asselah, Elahe Salimi Alizei, Özlem Sogukpinar, Frances Winkler, Sian Llewellyn-Lacey, Florian Emmerich, David A. Price, Tobias Boettler, Bertram Bengsch, Hendrik Luxenburger, Maike Hofmann, Robert Thimme, Pietro Lampertico, Christoph Neumann-Haefelin
Publié dans: JHEP Reports, Numéro 8, 2026, ISSN 2589-5559
Éditeur: Elsevier BV
DOI: 10.1016/J.JHEPR.2026.101970

Value and Kinetics of Virological Markers in the Natural Course of Chronic Hepatitis D Virus Infection

Auteurs: Lisa Sandmann, Valerie Ohlendorf, Alena Ehrenbauer, Birgit Bremer, Anke R. M. Kraft, Markus Cornberg, Katja Deterding, Heiner Wedemeyer, Benjamin Maasoumy
Publié dans: Liver International, Numéro 45, 2025, ISSN 1478-3223
Éditeur: Wiley
DOI: 10.1111/LIV.70003

Sequence analysis of the hepatitis D virus across genotypes reveals highly conserved regions amidst evidence of recombination

Auteurs: Shruti Chowdhury, Carina Jacobsen, Daniel P Depledge, Heiner Wedemeyer, Lisa Sandmann, Helenie Kefalakes
Publié dans: Virus Evolution, Numéro 11, 2025, ISSN 2057-1577
Éditeur: Oxford University Press (OUP)
DOI: 10.1093/VE/VEAF012

Course and clinical outcomes of chronic hepatitis delta: a longitudinal analysis of 565 patients from the D-SOLVE and HDV-1000 consortia

Auteurs: Habiba Kamal, Elisabetta Degasperi, Monica Radu, Dana Sambarino, Anika Wranke, Ivana Carey, Miroslava Subic-Levrero, Karin Lindahl, Lisa Sandmann, Petra Dörge, Julia Kahlhöfer, Fabien Zoulim, Kosh Agarwal, Soo Aleman, Florin Alexandru Caruntu, Pietro Lampertico, Heiner Wedemeyer
Publié dans: Gut, 2026, ISSN 0017-5749
Éditeur: BMJ
DOI: 10.1136/GUTJNL-2025-336234

Safety and efficacy of off-label bulevirtide monotherapy in HDV patients with decompensated Child-B cirrhosis - a real world case series.

Auteurs: Dietz-Fricke C, Degasperi E, Jachs M, Maasoumy B, Reiter FP, Geier A, Grottenthaler JM, Berg CP, Sprinzl K, Zeuzem S, Gödiker J, Schlevogt B, Herta T, Wiegand J, Soffredini R, Wedemeyer H, Deterding K, Reiberger T, Lampertico P.
Publié dans: Hepatology, 2024, ISSN 0270-9139
Éditeur: John Wiley & Sons Inc.
DOI: 10.1097/HEP.0000000000000847

Modeling hepatitis D virus kinetics during bulevirtide monotherapy: challenges and solutions

Auteurs: Adquate Mhlanga, Louis Shekhtman, Ashish Goyal, Elisabetta Degasperi, Maria Paola Anolli, Sara Colonia Uceda Renteria, Dana Sambarino, Marta Borghi, Riccardo Perbellini, Floriana Facchetti, Annapaola Callegaro, Scott J. Cotler, Pietro Lampertico, Harel Dahari
Publié dans: Journal of Theoretical Biology, Numéro 636, 2026, ISSN 0022-5193
Éditeur: Elsevier BV
DOI: 10.1016/J.JTBI.2026.112595

Frequency, Severity and Impact of Pegylated Interferon Alpha–Associated Flares in Hepatitis D Infection

Auteurs: Svenja Hardtke, Cihan Yurdaydin, Florin A. Caruntu, Manuela G. Curescu, Kendal Yalcin, Ulus S. Akarca, Selim Gürel, Stefan Zeuzem, Andreas Erhardt, Stefan Lüth, George V. Papatheodoridis, Kerstin Port, Michael P. Manns, Markus Cornberg, Julia Kahlhöfer, Heiner Wedemeyer
Publié dans: Journal of Viral Hepatitis, Numéro 32, 2025, ISSN 1352-0504
Éditeur: Wiley
DOI: 10.1111/JVH.70022

HDV RNA Undetectability Rates During Bulevirtide Monotherapy in Patients With Chronic Hepatitis Delta May Be Assay Dependent

Auteurs: Maria Paola Anolli, Sara Uceda Renteria, Elisabetta Degasperi, Floriana Facchetti, Dana Sambarino, Marta Borghi, Roberta Soffredini, Sara Monico, Annapaola Callegaro, Pietro Lampertico
Publié dans: Liver International, Numéro 46, 2026, ISSN 1478-3223
Éditeur: Wiley
DOI: 10.1111/LIV.70677

A Phase 3, Randomized Trial of Bulevirtide in Chronic Hepatitis D

Auteurs: Wedemeyer H, Aleman S, Brunetto MR, Blank A, Andreone P, Bogomolov P, Chulanov V, Mamonova N, Geyvandova N, Morozov V, Sagalova O, Stepanova T, Berger A, Manuilov D, Suri V, An Q, Da B, Flaherty J, Osinusi A, Liu Y, Merle U, Schulze Zur Wiesch J, Zeuzem S
Publié dans: NEJM, 2023, ISSN 0028-4793
Éditeur: Massachusetts Medical Society
DOI: 10.1056/NEJMoa2213429

Improving immunotherapy for the treatment of hepatocellular carcinoma: learning from patients and preclinical models

Auteurs: Romain Desert, Fabio Gianonne, Antonio Saviano, Yujin Hoshida, Mathias Heikenwälder, Pierre Nahon, Thomas F. Baumert
Publié dans: npj Gut and Liver, Numéro 2, 2025, ISSN 3004-9806
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/S44355-025-00018-Y

Natural history of untreated HDV patients: Always a progressive disease?

Auteurs: Kamal H, Aleman S; D-SOLVE Consortium
Publié dans: Liver International, 2023, ISSN 1478-3223
Éditeur: Liver International
DOI: 10.1111/liv.15467

Treating hepatitis D with bulevirtide – Real-world experience from 114 patients

Auteurs: Christopher Dietz-Fricke; Frank Tacke; Caroline Zöllner; Münevver Demir; Hartmut H. Schmidt; Christoph Schramm; Katharina Willuweit; Christian M. Lange; Sabine Weber; Gerald Denk; Christoph P. Berg; Julia M. Grottenthaler; Uta Merle; Alexander Olkus; Stefan Zeuzem; Kathrin Sprinzl; Thomas Berg; Florian van Bömmel; Johannes Wiegand; Toni Herta; Thomas Seufferlein; Eugen Zizer; Nektarios Dikopoulos; Robert Thimme; Christoph Neumann-Haefelin; Peter R. Galle; Martin Sprinzl; Ansgar W. Lohse; Julian Schulze zur Wiesch; Jan Kempski; Andreas Geier; Florian P. Reiter; Bernhard Schlevogt; Juliana Gödiker; Wolf Peter Hofmann; Peter Buggisch; Julia Kahlhöfer; Kerstin Port; Benjamin Maasoumy; Markus Cornberg; Heiner Wedemeyer; Katja Deterding
Publié dans: JHEP Reports, 2023, ISSN 2589-5559
Éditeur: JHEP Reports
DOI: 10.1016/J.JHEPR.2023.100686

Long‐term outcome of hepatitis delta in different regions world‐wide: Results of the Hepatitis Delta International Network

Auteurs: Anika Wranke, Cirley Lobato, Emanoil Ceausu, George N. Dalekos, Mario Rizzetto, Adela Turcanu, Grazia A. Niro, Onur Keskin, George Gherlan, Minaam Abbas, Patrick Ingiliz, Marion Muche, Maria Buti, Mathias Jachs, Thomas Vanwolleghem, Markus Cornberg, Zaigham Abbas, Cihan Yurdaydin, Petra Dörge, Heiner Wedemeyer, null null
Publié dans: Liver International, Numéro 44, 2025, ISSN 1478-3223
Éditeur: Wiley
DOI: 10.1111/LIV.16006

Clinical evaluation of the Altostar HDV RT-PCR Kit 1.5

Auteurs: Julia Carolin Eichholz, Birgit Bremer, Heiner Wedemeyer, Benjamin Maasoumy, Lisa Sandmann
Publié dans: Journal of Clinical Virology, Numéro 185, 2026, ISSN 1386-6532
Éditeur: Elsevier BV
DOI: 10.1016/J.JCV.2026.105971

Treatment response to bulevirtide is linked to amelioration of portal hypertension in patients with chronic hepatitis D

Auteurs: Lisa Sandmann, Mathias Jachs, Tammo L. Tergast, Lukas Hartl, Birgit Bremer, Martin A. Kabelitz, Michael Schwarz, Julius F.M. Egge, Lorenz Balcar, Benedikt Silvester Hofer, Christine S. Falk, Albert Friedrich Stättermayer, Markus Cornberg, Michael Trauner, Katja Deterding, Mattias Mandorfer, Heiner Wedemeyer, Thomas Reiberger, Benjamin Maasoumy
Publié dans: JHEP Reports, Numéro 8, 2026, ISSN 2589-5559
Éditeur: Elsevier BV
DOI: 10.1016/J.JHEPR.2025.101643

Unraveling the liver antiviral immunity in functional cure of chronic hepatitis B using scRNAseq

Auteurs: Pierre Tonnerre, Thomas F. Baumert
Publié dans: Journal of Hepatology, Numéro 81, 2024, ISSN 0168-8278
Éditeur: Elsevier BV
DOI: 10.1016/J.JHEP.2024.03.017

Ten‐Year Follow‐Up After 96 Weeks Treatment With Peginterferon Plus Tenofovir in Hepatitis D (HIDIT‐II): Improved Clinical Outcome After Combination Therapy

Auteurs: Cihan Yurdaydin, Julia Kahlhöfer, Florin Alexandru Caruntu, Kendal Yalcin, Selim Gürel, Ulus S. Akarca, Kathrin Sprinzl, Hans H. Bock, Jan‐Hendrik Bockmann, George V. Papatheodoridis, Uta Merle, Münevver Demir, Svenja Hardtke, Onur Keskin, Ramazan Idilman, Markus Cornberg, Heiner Wedemeyer, Anika Wranke
Publié dans: United European Gastroenterology Journal, Numéro 14, 2026, ISSN 2050-6406
Éditeur: Wiley
DOI: 10.1002/UEG2.70153

Real-world effectiveness and safety of bulevirtide monotherapy for up to 96 weeks in patients with HDV-related cirrhosis

Auteurs: Elisabetta Degasperi, Maria Paola Anolli, Mathias Jachs, Thomas Reiberger, Victor De Ledinghen, Sophie Metivier, Gianpiero D’Offizi, Francesco di Maria, Christoph Schramm, Hartmut Schmidt, Caroline Zöllner, Frank Tacke, Christopher Dietz-Fricke, Heiner Wedemeyer, Margarita Papatheodoridi, George Papatheodoridis, Ivana Carey, Kosh Agarwal, Florian Van Bömmel, Maurizia R. Brunetto, Mariana Cardoso, Gabriella Verucchi, Alessia Ciancio, Fabien Zoulim, Soo Aleman, Nasser Semmo, Alessandra Mangia, Marie-Noelle Hilleret, Uta Merle, Teresa A. Santantonio, Nicola Coppola, Adriano Pellicelli, Bruno Roche, Xavier Causse, Louis D’Alteroche, Jérome Dumortier, Nathalie Ganne, Frederic Heluwaert, Isabelle Ollivier, Dominique Roulot, Mauro Viganò, Alessandro Loglio, Alessandro Federico, Francesca Pileri, Monia Maracci, Matteo Tonnini, Jean-Pierre Arpurt, Karl Barange, Eric Billaud, Stanislas Pol, Anne Gervais, Anne Minello, Isabelle Rosa, Massimo Puoti, Pietro Lampertico
Publié dans: Journal of Hepatology, Numéro 82, 2025, ISSN 0168-8278
Éditeur: Elsevier BV
DOI: 10.1016/J.JHEP.2024.12.044

Quality‐of‐life scores improve after 96 weeks of <scp>PEG‐IFNa</scp>‐2a treatment of hepatitis D: An analysis of the <scp>HIDIT‐II</scp> trial

Auteurs: Katja Dinkelborg, Julia Kahlhöfer, Petra Dörge, Cihan Yurdaydin, Svenja Hardtke, Florin Alexandru Caruntu, Manuela G. Curescu, Kendal Yalcin, Ulus S. Akarca, Selim Gürel, Stefan Zeuzem, Andreas Erhardt, Stefan Lüth, George V. Papatheodoridis, Onur Keskin, Kerstin Port, Monica Radu, Mustafa K. Celen, Ramazan Idilman, Kristina Weber, Judith Stift, Ulrike Wittkop, Benjamin Heidrich, Ingmar Mederacke, Heiko von der Leyen, Hans Peter Dienes, Markus Cornberg, Armin Koch, Michael P. Manns, Heiner Wedemeyer, Katja Deterding, null null
Publié dans: Liver International, Numéro 43, 2023, ISSN 1478-3223
Éditeur: Wiley
DOI: 10.1111/LIV.15602

Letter to the Editor: The WHO HDV RNA international standard does not reflect variability of real-world samples

Auteurs: Lisa Sandmann, Birgit Bremer, Katja Deterding, Kerstin Port, Beatrix Gey, Christian Früchtel, André Reinhardt, Ingolf Lachmann, Markus Cornberg, Helenie Kefalakes, Benjamin Maasoumy, Heiner Wedemeyer
Publié dans: Hepatology, Numéro 81, 2025, ISSN 0270-9139
Éditeur: Ovid Technologies (Wolters Kluwer Health)
DOI: 10.1097/HEP.0000000000000975

Targeting immuno-metabolism and anti-viral immune responses in chronic hepatitis B

Auteurs: Suzanne Faure-Dupuy, Thomas F. Baumert
Publié dans: Hepatology International, Numéro 17, 2023, ISSN 1936-0533
Éditeur: Springer Science and Business Media LLC
DOI: 10.1007/S12072-023-10546-5

Understanding Data Importance in Machine Learning Attacks: Does Valuable Data Pose Greater Harm?

Auteurs: Rui Wen, Michael Backes, Yang Zhang
Publié dans: Proceedings 2025 Network and Distributed System Security Symposium, 2025
Éditeur: Internet Society
DOI: 10.14722/NDSS.2025.230331

SoK: Data Reconstruction Attacks Against Machine Learning Models: Definition, Metrics, and Benchmark

Auteurs: Rui Wen, Yiyong Liu, Michael Backes, Yang Zhang
Publié dans: Proceedings of the 34th USENIX Security Symposium is sponsored by USENIX, 2025
Éditeur: USENIX Association
DOI: 10.5281/ZENODO.15603060

SecurityNet: Assessing Machine Learning Vulnerabilities on Public Models

Auteurs: Boyang Zhang, Zheng Li, Ziqing Yang, Xinlei He, Michael Backes, Mario Fritz, Yang Zhang
Publié dans: Proceedings des 33rd USENIX Security Symposium (2024), 2024
Éditeur: USENIX Association
DOI: 10.48550/ARXIV.2310.12665

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