Understanding the individual host response against Hepatitis D Virus to develop a personalized approach for the management of hepatitis D

CORDIS bietet Links zu öffentlichen Ergebnissen und Veröffentlichungen von HORIZONT-Projekten.

Links zu Ergebnissen und Veröffentlichungen von RP7-Projekten sowie Links zu einigen Typen spezifischer Ergebnisse wie Datensätzen und Software werden dynamisch von OpenAIRE abgerufen.

Leistungen

Plan for dissemination and exploitation of results (M6)

A strategic plan for the dissemination and exploitation of results is available.

Project website, brochure, logo, Twitter account

Project website will be launched.Information material as a brochure will be available.A consortium logo will be ready.Social media accounts will be implemented.

Established of fine-needle aspiration protocol and training of physicians at all clinical site

SOP document; training workshop for trial staff

Data Management Plan

The plan outlines all the data that will be collected and generated during the project, how it will be created, stored and backed-up, who owns it and who is responsible for the different data and which data will be preserved and shared, according to the participation of the project in the Open Data Research Pilot.

A general risk assessment tool/platform

A software platform with a website interface that can be used for data risk assessment for all partners in the project

Final version of study protocol as approved by the regulator(s) / ethics committee(s) and trial registration

Study protocol submitted to a journal, registration on a website

Security and privacy risk assessment report

A scientific report/paper about the security and privacy risk assessment, including threat model, method, and results

Promotional literature (e.g. leaflets, slide deck) with information about the project to be used as a communication tool at scientific events and workshops attended by consortium members

Additional promotional literature (e.g. leaflets, slide deck) with information about the project to be used as a communication tool at scientific events and workshops attended by consortium members are designed and available

General project Management Plan

Project internal management plan, elaborating on relevant internal procedures and responsibilities, rules and guidelines, and clarifying baseline EC requirements for effective and efficient collaboration, communication and dissemination - guidelines and templates for the execution of the project included.

Finalization of the study protocol of the bulevirtide stop trial including ethics submission

Study protocol, proof of ethic submission

Clinical protocol and establishment of the redcap electronic case-report form

Protocol document, redcap ECRF-form online available for HDV 750 cohort.

New attack methods and their implementation

A document describing method/algorithms on the potential attacks for the system, and their software implementation

D-SOLVE academy established

The D-SOLVE academy will be founded to enable exchange between D-SOLVE centers. The concept of the academy will be agreed on and be implemented at M12.

Implementation of an Ethics & Scientific Advisory Board (ESAB), a Data Safety Monitoring Board (in cooperation with WP6) for the clinical trial (DSMB), and an Innovation Management Board (IMB)
Attack evaluation results

A document summarizing the experimental evaluation for the attacks from D6.2

Veröffentlichungen

Phase 2 Randomised Study of Bulevirtide as Monotherapy or Combined With Peg‐<scp>IFNα</scp>‐2a as Treatment for Chronic Hepatitis Delta

Autoren: Pietro Lampertico, Pavel O. Bogomolov, Vladimir Chulanov, Tatiana Stepanova, Viacheslav Morozov, Lena Allweiss, Maura Dandri, Jürgen Burhenne, Antje Blank, Sandra Ciesek, Carina Elsner, Ulf Dittmer, Qi An, Dmitry Manuilov, Ben L. Da, John F. Flaherty, Stephan Urban, Heiner Wedemeyer
Veröffentlicht in: Liver International, Ausgabe 45, 2025, ISSN 1478-3223
Herausgeber: Wiley
DOI: 10.1111/LIV.70008

Autoren: Giannone F, Slovic N, Pessaux P, Schuster C, Baumert TF, Lupberger J.
Veröffentlicht in: Front. Oncol, 2023, ISSN 2234-943X
Herausgeber: Frontiers Media S. A.
DOI: 10.3389/fonc.2023.1267870

High Rates of Advanced Chronic Liver Disease in Patients With Chronic Hepatitis D Virus Infection in Uzbekistan

Autoren: Malika E. Khodjaeva, Aziza S. Khikmatullaeva, Nargiz S. Ibadullaeva, Gulnara K. Khudaykulova, Munisa M. Ilyasova, Kamila U. Eshbayeva, Dildorakhon N. Abdurakhmanova, Helenie Kefalakes, Petra Huber, Michael J. Gebel, Erkin I. Musabaev, Heiner Wedemeyer, Lisa Sandmann
Veröffentlicht in: Liver International, Ausgabe 46, 2026, ISSN 1478-3223
Herausgeber: Wiley
DOI: 10.1111/LIV.70799

Diabetes, male sex, low levels of HBsAg, HDV RNA, and ALT predict spontaneous HDV suppression in chronic hepatitis D

Autoren: Habiba Kamal, Ganbolor Jargalsaikhan, Sanjaasuren Enkhtaivan, Karin Lindahl, Bekhbold Dashtseren, Oyungerel Lkhagva-Ochir, Tuvshinjargal Ulziibadrakh, Andreas Bungert, Elisabetta Degasperi, Pietro Lampertico, Heiner Wedemeyer, Naranjargal B. Dashdorj, Soo Aleman
Veröffentlicht in: Hepatology, 2026, ISSN 0270-9139
Herausgeber: Ovid Technologies (Wolters Kluwer Health)
DOI: 10.1097/HEP.0000000000001786

Differential HBV RNA and HBcrAg patterns in untreated patients with chronic hepatitis delta

Autoren: Elisabetta Degasperi, Caroline Scholtes, Barbara Testoni, Sara Uceda Renteria, Maria Paola Anolli, Caroline Charre, Floriana Facchetti, Marie-Laure Plissonnier, Dana Sambarino, Riccardo Perbellini, Sara Monico, Annapaola Callegaro, Ester García-Pras, Sabela Lens, Maria Francesca Cortese, Xavier Forns, Sofía Pérez-del-Pulgar, Marintha Heil, Massimo Levrero, Fabien Zoulim, Pietro Lampertico
Veröffentlicht in: Journal of Hepatology, Ausgabe 82, 2025, ISSN 0168-8278
Herausgeber: Elsevier BV
DOI: 10.1016/J.JHEP.2024.11.051

Hepatitis D virus—still the devil!

Autoren: Anika Wranke, Heiner Wedemeyer
Veröffentlicht in: Hepatology, Ausgabe 81, 2025, ISSN 0270-9139
Herausgeber: Ovid Technologies (Wolters Kluwer Health)
DOI: 10.1097/HEP.0000000000001144

Sodium taurocholate cotransporting polypeptide (NTCP) polymorphisms may influence HDV RNA load and early response to bulevirtide

Autoren: Pierluigi Toniutto, Edmondo Falleti, Sara Cmet, Annarosa Cussigh, Elisabetta Degasperi, Maria Paola Anolli, Dana Sambarino, Floriana Facchetti, Marta Borghi, Riccardo Perbellini, Sara Monico, Pietro Lampertico
Veröffentlicht in: Journal of Hepatology, Ausgabe 81, 2025, ISSN 0168-8278
Herausgeber: Elsevier BV
DOI: 10.1016/J.JHEP.2024.06.013

Droplet Digital PCR: A Powerful Tool for Accurate Quantification of Hepatitis D Virus RNA Levels and Verification of Detection Limits

Autoren: L. Sandmann, L. Windzio, B. Bremer, S. Falak, J. Beheim‐Schwarzbach, A. Kummrow, M. Cornberg, H. Wedemeyer, B. Maasoumy, E. Valiente
Veröffentlicht in: Journal of Viral Hepatitis, Ausgabe 32, 2025, ISSN 1352-0504
Herausgeber: Wiley
DOI: 10.1111/JVH.70036

Prevalence of chronic viral hepatitis B, D among Mongol migrants in Sweden compared to a sex- and age-matched native Mongol cohort

Autoren: Delgersaikhan Zulkhuu, Habiba Kamal, Sanjaasuren Enkhtaivan, Ochirmaa Narantsogt, Ganbolor Jargalsaikhan, Munguntsetseg Batkhuu, Byambasuren Ochirsum, Marcus Ahl, Karin Lindahl, Michael Ingre, Natalie Stiglund, Alexandros Petropoulos, Gustaf Sandh, Niklas K. Björkström, Sonja Saario, Susanne Cederberg, Annika Olsson, Anna Wange Baye, Ihssan Derdabi, Desideria Georgos, Andreas S. Bungert, Nara Bungert Dashdorj, N. D. Dashdorj Onom, Soo Aleman
Veröffentlicht in: BMC Infectious Diseases, Ausgabe 26, 2026, ISSN 1471-2334
Herausgeber: Springer Science and Business Media LLC
DOI: 10.1186/S12879-025-12506-W

144 Weeks of bulevirtide monotherapy for chronic hepatitis D: Final and post-treatment results from a phase III randomized trial

Autoren: Heiner Wedemeyer, Soo Aleman, Antje Blank, Pietro Andreone, Pavel Bogomolov, Vladimir Chulanov, Nina Mamonova, Natalia Geyvandova, Viacheslav Morozov, Olga Sagalova, Tatiana Stepanova, Annemarie Berger, Sandra Ciesek, Amos Lichtman, Dmitry Manuilov, Renee-Claude Mercier, Sarah Arterburn, Florence Christian-Cox, Steve Tseng, Anu Osinusi, Julian Schulze zur Wiesch, Markus Cornberg, Stefan Zeuzem, Maurizia Rossana Brunetto, Pietro Lampertico
Veröffentlicht in: Journal of Hepatology, Ausgabe 85, 2026, ISSN 0168-8278
Herausgeber: Elsevier BV
DOI: 10.1016/J.JHEP.2026.03.046

Antiviral therapy for chronic hepatitis delta: new insights from clinical trials and real-life studies

Autoren: Pietro Lampertico, Maria Paola Anolli, Dominique Roulot, Heiner Wedemeyer
Veröffentlicht in: Gut, Ausgabe 74, 2025, ISSN 0017-5749
Herausgeber: BMJ
DOI: 10.1136/GUTJNL-2024-332597

Validation of Baveno VII criteria and other non-invasive diagnostic algorithms for clinically significant portal hypertension in hepatitis delta

Autoren: Jachs M, Sandmann L, Hartl L, Tergast T, Schwarz M, Bauer DJM, Balcar L, Ehrenbauer A, Hofer BS, Cornberg M, Lenzen H, Deterding K, Trauner M, Mandorfer M, Wedemeyer H, Reiberger T, Maasoumy B.
Veröffentlicht in: Journal of Hepatology, 2024, ISSN 1600-0641
Herausgeber: Journal of Hepatology
DOI: 10.1016/j.jhep.2024.03.005

TIGIT expression on natural killer cell subsets is an early indicator of alleviating liver inflammation following bulevirtide treatment in chronic hepatitis D

Autoren: Po-Chun Chen, Katja Deterding, Sophie Anna Engelskircher, Kerstin Port, Lisa Sandmann, Athira Chakkadath, Tijana Ristic, Qingyu Wu, Birgit Bremer, Anke R.M. Kraft, Markus Cornberg, Albert Heim, Helenie Kefalakes, Niklas K. Björkström, Norman Woller, Heiner Wedemeyer
Veröffentlicht in: Hepatology, 2025, ISSN 0270-9139
Herausgeber: Ovid Technologies (Wolters Kluwer Health)
DOI: 10.1097/HEP.0000000000001238

Comparing methods for plasma HDV RNA quantification in bulevirtide-treated and untreated patients with HDV

Autoren: Maria Paola Anolli, Sara Uceda Renteria, Elisabetta Degasperi, Floriana Facchetti, Dana Sambarino, Marta Borghi, Riccardo Perbellini, Roberta Soffredini, Sara Monico, Annapaola Callegaro, Pietro Lampertico
Veröffentlicht in: JHEP Reports, Ausgabe 7, 2025, ISSN 2589-5559
Herausgeber: Elsevier BV
DOI: 10.1016/J.JHEPR.2024.101299

Liver stiffness measurement as a noninvasive method for the diagnosis of liver cirrhosis in patients with chronic hepatitis D virus infection.

Autoren: Sandmann L, Degasperi E, Port K, Aleman S, Wallin JJ, Manuilov D, Da BL, Cornberg M, Lampertico P, Maasoumy B, Wedemeyer H, Deterding K
Veröffentlicht in: Aliment Pharmacol Ther, 2024, ISSN 1365-2036
Herausgeber: Aliment Pharmacol Ther
DOI: 10.1111/apt.17878

Hepatitis D Virus Infection: Pathophysiology, Epidemiology and Treatment. Report From the Third Delta Cure Meeting 2024

Autoren: Elisabetta Degasperi, Lisa Sandmann, Heiner Wedemeyer, Pietro Lampertico, null null
Veröffentlicht in: Liver International, Ausgabe 45, 2025, ISSN 1478-3223
Herausgeber: Wiley
DOI: 10.1111/LIV.70189

Memories of Stress: The Imprinted Cancer Risk After HCV Cure

Autoren: Lupberger, Joachim; Baumert, Thomas F.
Veröffentlicht in: Cellular and Molecular Gastroenterology and Hepatology, 2023, ISSN 2352-345X
Herausgeber: Elsevier Inc.
DOI: 10.1016/j.jcmgh.2023.05.006

Bile acid increase during bulevirtide treatment of hepatitis D is not associated with a decline in HDV RNA

Autoren: Deterding K, Xu C, Port K, Dietz-Fricke C, Xun J, Maasoumy B, Cornberg M, Wedemeyer H.
Veröffentlicht in: J Viral Hepat., 2023, ISSN 1352-0504
Herausgeber: Blackwell Publishing Inc.
DOI: 10.1111/jvh.13831.

"Antiviral Therapy of Chronic Hepatitis D Virus Infection - Addendum to the S3 Guideline ""Prophylaxis, Diagnosis and Therapy of Hepatitis B Virus Infection"" of the German Society for Gastroenterology, Digestive and Metabolic Diseases (DGVS)"

Autoren: Sandmann L, Berg T, Deterding K, Fischer N, Hinrichsen H, Petersen J, Tacke F, Cornberg M
Veröffentlicht in: Zeitschrift für Gastroenterologie, 2023, ISSN 0044-2771
Herausgeber: Georg Thieme Verlag
DOI: 10.1055/a-2181-3345

siRNA JNJ-73763989 decreases HBsAg and HDV RNA in NA-treated hepatitis D patients but may cause ALT flares

Autoren: Heiner Wedemeyer, Ed Gane, Kosh Agarwal, Ömer Fehmi Tabak, Xavier Forns, Ulus Salih Akarca, Viacheslav Morozov, Soo Aleman, Maria Buti, Gurdal Yilmaz, Pietro Lampertico, John Jezorwski, Thomas N. Kakuda, Adam Bakala, Nonko Pehlivanov, Thierry Verbinnen, Oliver Lenz, Michael Biermer
Veröffentlicht in: Journal of Hepatology, Ausgabe 85, 2026, ISSN 0168-8278
Herausgeber: Elsevier BV
DOI: 10.1016/J.JHEP.2026.05.007

Five‐year follow‐up of 96 weeks peginterferon plus tenofovir disoproxil fumarate in hepatitis D

Autoren: Olympia E. Anastasiou, Florin A. Caruntu, Manuela G. Curescu, Kendal Yalcin, Ulus S. Akarca, Selim Gürel, Stefan Zeuzem, Andreas Erhardt, Stefan Lüth, George V. Papatheodoridis, Onur Keskin, Kerstin Port, Monica Radu, Mustafa K. Celen, Ramazan Idilman, Benjamin Heidrich, Ingmar Mederacke, Heiko von der Leyen, Julia Kahlhöfer, Maria von Karpowitz, Svenja Hardtke, Markus Cornberg, Cihan Yurdaydin, Heiner Wedemeyer
Veröffentlicht in: Liver International, Ausgabe 44, 2024, ISSN 1478-3223
Herausgeber: Wiley
DOI: 10.1111/LIV.15745

Quality of life improves during antiviral therapy with bulevirtide

Autoren: Julia Carolin Eichholz, Christopher Dietz-Fricke, Simon Kristian Mrowietz, Katja Dinkelborg, Kerstin Port, Heiner Wedemeyer, Katja Deterding
Veröffentlicht in: Zeitschrift für Gastroenterologie, Ausgabe 63, 2025, ISSN 0044-2771
Herausgeber: Georg Thieme Verlag KG
DOI: 10.1055/A-2633-6361

Unraveling the genetic susceptibility to HBV-related liver cancer: The role of virus–host immune interactions

Autoren: Pierre Tonnerre, Yujin Hoshida, Thomas F. Baumert
Veröffentlicht in: Hepatology, 2025, ISSN 0270-9139
Herausgeber: Ovid Technologies (Wolters Kluwer Health)
DOI: 10.1097/HEP.0000000000001355

Hepatitis delta virus co-infection in patients with hepatocellular carcinoma and people living with HIV in Nigeria

Autoren: Ijeoma Ifeorah, Birgit Bremer, Yusuf Musa, Julia Kahlhöfer, Oluwatosin Oguntoye, Carey Tishiya, Gatuwa Aglavdawa, Ojonuga Ameh, Yussuf Abdulkadir, Olumuyiwa Ariyo, Manfred Anim, Andre Reinhardt, Albert Heim, Uwem George, Lukman Abdulkareem, Ibrahim Umar Garzali, Heiner Wedemeyer, Lisa Sandmann
Veröffentlicht in: BMC Infectious Diseases, Ausgabe 26, 2026, ISSN 1471-2334
Herausgeber: Springer Science and Business Media LLC
DOI: 10.1186/S12879-026-12913-7

An atlas of the human liver diurnal transcriptome and its perturbation by hepatitis C virus infection

Autoren: Atish Mukherji, Frank Jühling, Yogy Simanjuntak, Emilie Crouchet, Fabio Del Zompo, Yuji Teraoka, Alexandre Haller, Philippe Baltzinger, Soumith Paritala, Fahmida Rasha, Naoto Fujiwara, Cloé Gadenne,
Veröffentlicht in: Nature Communications, Ausgabe 15, 2024, ISSN 2041-1723
Herausgeber: Springer Science and Business Media LLC
DOI: 10.1038/S41467-024-51698-8

Bulevirtide Monotherapy or in Combination for Chronic Hepatitis Delta: 2025 Update

Autoren: Pietro Lampertico, Maria Paola Anolli, Katja Steppich, Heiner Wedemeyer
Veröffentlicht in: Journal of Viral Hepatitis, Ausgabe 32, 2025, ISSN 1352-0504
Herausgeber: Wiley
DOI: 10.1111/JVH.70056

Hepatitis D virus infection: Pathophysiology, epidemiology and treatment. Report from the first international delta cure meeting 2022

Autoren: Lampertico P, Degasperi E, Sandmann L, Wedemeyer H; Delta Cure 2022 Working Group
Veröffentlicht in: JHEP Reports, 2023, ISSN 2589-5559
Herausgeber: JHEP Reports
DOI: 10.1016/j.jhepr.2023.100818

Exploiting the immunopathogenesis of hepatitis D virus infection to develop superior treatment options

Autoren: Rahaf Albarghash, Carina Jacobsen, Helenie Kefalakes
Veröffentlicht in: Antiviral Research, Ausgabe 250, 2026, ISSN 0166-3542
Herausgeber: Elsevier BV
DOI: 10.1016/J.ANTIVIRAL.2026.106416

Clinical long-term outcome of hepatitis D compared to hepatitis B monoinfection.

Autoren: Wranke A, Heidrich B, Deterding K, Hupa-Breier KL, Kirschner J, Bremer B, Cornberg M, Wedemeyer H.
Veröffentlicht in: Hepatol Int., 2023, ISSN 1936-0541
Herausgeber: Hepatol Int.
DOI: 10.1007/s12072-023-10575-0

HDV RNA Assays Writing Group at the HBV Forum. HDV RNA assays: Performance characteristics, clinical utility, and challenges

Autoren: Wedemeyer H, Leus M, Battersby TR, Glenn J, Gordien E, Kamili S, Kapoor H, Kessler HH, Lenz O, Lütgehetmann M, Mixson-Hayden T, Simon CO, Thomson M, Westman G, Miller V, Terrault N, Lampertico P
Veröffentlicht in: Hepatology, 2023, ISSN 0270-9139
Herausgeber: John Wiley & Sons Inc.
DOI: 10.1097/HEP.0000000000000584

Fate of hepatitis D virus-specific CD8+ T cells during bulevirtide monotherapy in patients with chronic hepatitis delta

Autoren: Valerie Oberhardt, Elisabetta Degasperi, Michelle Maas, Marta Borghi, Kathrin Heim, Roberta Soffredini, Maria Paola Anolli, Floriana Facchetti, Stéphanie Narguet, Tarik Asselah, Elahe Salimi Alizei, Özlem Sogukpinar, Frances Winkler, Sian Llewellyn-Lacey, Florian Emmerich, David A. Price, Tobias Boettler, Bertram Bengsch, Hendrik Luxenburger, Maike Hofmann, Robert Thimme, Pietro Lampertico, Christoph Neumann-Haefelin
Veröffentlicht in: JHEP Reports, Ausgabe 8, 2026, ISSN 2589-5559
Herausgeber: Elsevier BV
DOI: 10.1016/J.JHEPR.2026.101970

Value and Kinetics of Virological Markers in the Natural Course of Chronic Hepatitis D Virus Infection

Autoren: Lisa Sandmann, Valerie Ohlendorf, Alena Ehrenbauer, Birgit Bremer, Anke R. M. Kraft, Markus Cornberg, Katja Deterding, Heiner Wedemeyer, Benjamin Maasoumy
Veröffentlicht in: Liver International, Ausgabe 45, 2025, ISSN 1478-3223
Herausgeber: Wiley
DOI: 10.1111/LIV.70003

Sequence analysis of the hepatitis D virus across genotypes reveals highly conserved regions amidst evidence of recombination

Autoren: Shruti Chowdhury, Carina Jacobsen, Daniel P Depledge, Heiner Wedemeyer, Lisa Sandmann, Helenie Kefalakes
Veröffentlicht in: Virus Evolution, Ausgabe 11, 2025, ISSN 2057-1577
Herausgeber: Oxford University Press (OUP)
DOI: 10.1093/VE/VEAF012

Course and clinical outcomes of chronic hepatitis delta: a longitudinal analysis of 565 patients from the D-SOLVE and HDV-1000 consortia

Autoren: Habiba Kamal, Elisabetta Degasperi, Monica Radu, Dana Sambarino, Anika Wranke, Ivana Carey, Miroslava Subic-Levrero, Karin Lindahl, Lisa Sandmann, Petra Dörge, Julia Kahlhöfer, Fabien Zoulim, Kosh Agarwal, Soo Aleman, Florin Alexandru Caruntu, Pietro Lampertico, Heiner Wedemeyer
Veröffentlicht in: Gut, 2026, ISSN 0017-5749
Herausgeber: BMJ
DOI: 10.1136/GUTJNL-2025-336234

Safety and efficacy of off-label bulevirtide monotherapy in HDV patients with decompensated Child-B cirrhosis - a real world case series.

Autoren: Dietz-Fricke C, Degasperi E, Jachs M, Maasoumy B, Reiter FP, Geier A, Grottenthaler JM, Berg CP, Sprinzl K, Zeuzem S, Gödiker J, Schlevogt B, Herta T, Wiegand J, Soffredini R, Wedemeyer H, Deterding K, Reiberger T, Lampertico P.
Veröffentlicht in: Hepatology, 2024, ISSN 0270-9139
Herausgeber: John Wiley & Sons Inc.
DOI: 10.1097/HEP.0000000000000847

Modeling hepatitis D virus kinetics during bulevirtide monotherapy: challenges and solutions

Autoren: Adquate Mhlanga, Louis Shekhtman, Ashish Goyal, Elisabetta Degasperi, Maria Paola Anolli, Sara Colonia Uceda Renteria, Dana Sambarino, Marta Borghi, Riccardo Perbellini, Floriana Facchetti, Annapaola Callegaro, Scott J. Cotler, Pietro Lampertico, Harel Dahari
Veröffentlicht in: Journal of Theoretical Biology, Ausgabe 636, 2026, ISSN 0022-5193
Herausgeber: Elsevier BV
DOI: 10.1016/J.JTBI.2026.112595

Frequency, Severity and Impact of Pegylated Interferon Alpha–Associated Flares in Hepatitis D Infection

Autoren: Svenja Hardtke, Cihan Yurdaydin, Florin A. Caruntu, Manuela G. Curescu, Kendal Yalcin, Ulus S. Akarca, Selim Gürel, Stefan Zeuzem, Andreas Erhardt, Stefan Lüth, George V. Papatheodoridis, Kerstin Port, Michael P. Manns, Markus Cornberg, Julia Kahlhöfer, Heiner Wedemeyer
Veröffentlicht in: Journal of Viral Hepatitis, Ausgabe 32, 2025, ISSN 1352-0504
Herausgeber: Wiley
DOI: 10.1111/JVH.70022

HDV RNA Undetectability Rates During Bulevirtide Monotherapy in Patients With Chronic Hepatitis Delta May Be Assay Dependent

Autoren: Maria Paola Anolli, Sara Uceda Renteria, Elisabetta Degasperi, Floriana Facchetti, Dana Sambarino, Marta Borghi, Roberta Soffredini, Sara Monico, Annapaola Callegaro, Pietro Lampertico
Veröffentlicht in: Liver International, Ausgabe 46, 2026, ISSN 1478-3223
Herausgeber: Wiley
DOI: 10.1111/LIV.70677

A Phase 3, Randomized Trial of Bulevirtide in Chronic Hepatitis D

Autoren: Wedemeyer H, Aleman S, Brunetto MR, Blank A, Andreone P, Bogomolov P, Chulanov V, Mamonova N, Geyvandova N, Morozov V, Sagalova O, Stepanova T, Berger A, Manuilov D, Suri V, An Q, Da B, Flaherty J, Osinusi A, Liu Y, Merle U, Schulze Zur Wiesch J, Zeuzem S
Veröffentlicht in: NEJM, 2023, ISSN 0028-4793
Herausgeber: Massachusetts Medical Society
DOI: 10.1056/NEJMoa2213429

Improving immunotherapy for the treatment of hepatocellular carcinoma: learning from patients and preclinical models

Autoren: Romain Desert, Fabio Gianonne, Antonio Saviano, Yujin Hoshida, Mathias Heikenwälder, Pierre Nahon, Thomas F. Baumert
Veröffentlicht in: npj Gut and Liver, Ausgabe 2, 2025, ISSN 3004-9806
Herausgeber: Springer Science and Business Media LLC
DOI: 10.1038/S44355-025-00018-Y

Natural history of untreated HDV patients: Always a progressive disease?

Autoren: Kamal H, Aleman S; D-SOLVE Consortium
Veröffentlicht in: Liver International, 2023, ISSN 1478-3223
Herausgeber: Liver International
DOI: 10.1111/liv.15467

Treating hepatitis D with bulevirtide – Real-world experience from 114 patients

Autoren: Christopher Dietz-Fricke; Frank Tacke; Caroline Zöllner; Münevver Demir; Hartmut H. Schmidt; Christoph Schramm; Katharina Willuweit; Christian M. Lange; Sabine Weber; Gerald Denk; Christoph P. Berg; Julia M. Grottenthaler; Uta Merle; Alexander Olkus; Stefan Zeuzem; Kathrin Sprinzl; Thomas Berg; Florian van Bömmel; Johannes Wiegand; Toni Herta; Thomas Seufferlein; Eugen Zizer; Nektarios Dikopoulos; Robert Thimme; Christoph Neumann-Haefelin; Peter R. Galle; Martin Sprinzl; Ansgar W. Lohse; Julian Schulze zur Wiesch; Jan Kempski; Andreas Geier; Florian P. Reiter; Bernhard Schlevogt; Juliana Gödiker; Wolf Peter Hofmann; Peter Buggisch; Julia Kahlhöfer; Kerstin Port; Benjamin Maasoumy; Markus Cornberg; Heiner Wedemeyer; Katja Deterding
Veröffentlicht in: JHEP Reports, 2023, ISSN 2589-5559
Herausgeber: JHEP Reports
DOI: 10.1016/J.JHEPR.2023.100686

Long‐term outcome of hepatitis delta in different regions world‐wide: Results of the Hepatitis Delta International Network

Autoren: Anika Wranke, Cirley Lobato, Emanoil Ceausu, George N. Dalekos, Mario Rizzetto, Adela Turcanu, Grazia A. Niro, Onur Keskin, George Gherlan, Minaam Abbas, Patrick Ingiliz, Marion Muche, Maria Buti, Mathias Jachs, Thomas Vanwolleghem, Markus Cornberg, Zaigham Abbas, Cihan Yurdaydin, Petra Dörge, Heiner Wedemeyer, null null
Veröffentlicht in: Liver International, Ausgabe 44, 2025, ISSN 1478-3223
Herausgeber: Wiley
DOI: 10.1111/LIV.16006

Clinical evaluation of the Altostar HDV RT-PCR Kit 1.5

Autoren: Julia Carolin Eichholz, Birgit Bremer, Heiner Wedemeyer, Benjamin Maasoumy, Lisa Sandmann
Veröffentlicht in: Journal of Clinical Virology, Ausgabe 185, 2026, ISSN 1386-6532
Herausgeber: Elsevier BV
DOI: 10.1016/J.JCV.2026.105971

Treatment response to bulevirtide is linked to amelioration of portal hypertension in patients with chronic hepatitis D

Autoren: Lisa Sandmann, Mathias Jachs, Tammo L. Tergast, Lukas Hartl, Birgit Bremer, Martin A. Kabelitz, Michael Schwarz, Julius F.M. Egge, Lorenz Balcar, Benedikt Silvester Hofer, Christine S. Falk, Albert Friedrich Stättermayer, Markus Cornberg, Michael Trauner, Katja Deterding, Mattias Mandorfer, Heiner Wedemeyer, Thomas Reiberger, Benjamin Maasoumy
Veröffentlicht in: JHEP Reports, Ausgabe 8, 2026, ISSN 2589-5559
Herausgeber: Elsevier BV
DOI: 10.1016/J.JHEPR.2025.101643

Unraveling the liver antiviral immunity in functional cure of chronic hepatitis B using scRNAseq

Autoren: Pierre Tonnerre, Thomas F. Baumert
Veröffentlicht in: Journal of Hepatology, Ausgabe 81, 2024, ISSN 0168-8278
Herausgeber: Elsevier BV
DOI: 10.1016/J.JHEP.2024.03.017

Ten‐Year Follow‐Up After 96 Weeks Treatment With Peginterferon Plus Tenofovir in Hepatitis D (HIDIT‐II): Improved Clinical Outcome After Combination Therapy

Autoren: Cihan Yurdaydin, Julia Kahlhöfer, Florin Alexandru Caruntu, Kendal Yalcin, Selim Gürel, Ulus S. Akarca, Kathrin Sprinzl, Hans H. Bock, Jan‐Hendrik Bockmann, George V. Papatheodoridis, Uta Merle, Münevver Demir, Svenja Hardtke, Onur Keskin, Ramazan Idilman, Markus Cornberg, Heiner Wedemeyer, Anika Wranke
Veröffentlicht in: United European Gastroenterology Journal, Ausgabe 14, 2026, ISSN 2050-6406
Herausgeber: Wiley
DOI: 10.1002/UEG2.70153

Real-world effectiveness and safety of bulevirtide monotherapy for up to 96 weeks in patients with HDV-related cirrhosis

Autoren: Elisabetta Degasperi, Maria Paola Anolli, Mathias Jachs, Thomas Reiberger, Victor De Ledinghen, Sophie Metivier, Gianpiero D’Offizi, Francesco di Maria, Christoph Schramm, Hartmut Schmidt, Caroline Zöllner, Frank Tacke, Christopher Dietz-Fricke, Heiner Wedemeyer, Margarita Papatheodoridi, George Papatheodoridis, Ivana Carey, Kosh Agarwal, Florian Van Bömmel, Maurizia R. Brunetto, Mariana Cardoso, Gabriella Verucchi, Alessia Ciancio, Fabien Zoulim, Soo Aleman, Nasser Semmo, Alessandra Mangia, Marie-Noelle Hilleret, Uta Merle, Teresa A. Santantonio, Nicola Coppola, Adriano Pellicelli, Bruno Roche, Xavier Causse, Louis D’Alteroche, Jérome Dumortier, Nathalie Ganne, Frederic Heluwaert, Isabelle Ollivier, Dominique Roulot, Mauro Viganò, Alessandro Loglio, Alessandro Federico, Francesca Pileri, Monia Maracci, Matteo Tonnini, Jean-Pierre Arpurt, Karl Barange, Eric Billaud, Stanislas Pol, Anne Gervais, Anne Minello, Isabelle Rosa, Massimo Puoti, Pietro Lampertico
Veröffentlicht in: Journal of Hepatology, Ausgabe 82, 2025, ISSN 0168-8278
Herausgeber: Elsevier BV
DOI: 10.1016/J.JHEP.2024.12.044

Quality‐of‐life scores improve after 96 weeks of <scp>PEG‐IFNa</scp>‐2a treatment of hepatitis D: An analysis of the <scp>HIDIT‐II</scp> trial

Autoren: Katja Dinkelborg, Julia Kahlhöfer, Petra Dörge, Cihan Yurdaydin, Svenja Hardtke, Florin Alexandru Caruntu, Manuela G. Curescu, Kendal Yalcin, Ulus S. Akarca, Selim Gürel, Stefan Zeuzem, Andreas Erhardt, Stefan Lüth, George V. Papatheodoridis, Onur Keskin, Kerstin Port, Monica Radu, Mustafa K. Celen, Ramazan Idilman, Kristina Weber, Judith Stift, Ulrike Wittkop, Benjamin Heidrich, Ingmar Mederacke, Heiko von der Leyen, Hans Peter Dienes, Markus Cornberg, Armin Koch, Michael P. Manns, Heiner Wedemeyer, Katja Deterding, null null
Veröffentlicht in: Liver International, Ausgabe 43, 2023, ISSN 1478-3223
Herausgeber: Wiley
DOI: 10.1111/LIV.15602

Letter to the Editor: The WHO HDV RNA international standard does not reflect variability of real-world samples

Autoren: Lisa Sandmann, Birgit Bremer, Katja Deterding, Kerstin Port, Beatrix Gey, Christian Früchtel, André Reinhardt, Ingolf Lachmann, Markus Cornberg, Helenie Kefalakes, Benjamin Maasoumy, Heiner Wedemeyer
Veröffentlicht in: Hepatology, Ausgabe 81, 2025, ISSN 0270-9139
Herausgeber: Ovid Technologies (Wolters Kluwer Health)
DOI: 10.1097/HEP.0000000000000975

Targeting immuno-metabolism and anti-viral immune responses in chronic hepatitis B

Autoren: Suzanne Faure-Dupuy, Thomas F. Baumert
Veröffentlicht in: Hepatology International, Ausgabe 17, 2023, ISSN 1936-0533
Herausgeber: Springer Science and Business Media LLC
DOI: 10.1007/S12072-023-10546-5

Understanding Data Importance in Machine Learning Attacks: Does Valuable Data Pose Greater Harm?

Autoren: Rui Wen, Michael Backes, Yang Zhang
Veröffentlicht in: Proceedings 2025 Network and Distributed System Security Symposium, 2025
Herausgeber: Internet Society
DOI: 10.14722/NDSS.2025.230331

SoK: Data Reconstruction Attacks Against Machine Learning Models: Definition, Metrics, and Benchmark

Autoren: Rui Wen, Yiyong Liu, Michael Backes, Yang Zhang
Veröffentlicht in: Proceedings of the 34th USENIX Security Symposium is sponsored by USENIX, 2025
Herausgeber: USENIX Association
DOI: 10.5281/ZENODO.15603060

SecurityNet: Assessing Machine Learning Vulnerabilities on Public Models

Autoren: Boyang Zhang, Zheng Li, Ziqing Yang, Xinlei He, Michael Backes, Mario Fritz, Yang Zhang
Veröffentlicht in: Proceedings des 33rd USENIX Security Symposium (2024), 2024
Herausgeber: USENIX Association
DOI: 10.48550/ARXIV.2310.12665

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