Description du projet
Rôle des facteurs environnementaux dans la santé hépatique chez l’enfant
Un foie en mauvaise santé est un problème qui s’accompagne de conséquences à long terme. Dans le monde occidental, des niveaux élevés de marqueurs de lésions hépatiques et de stéatose hépatique non alcoolique chez l’enfant sont de plus en plus souvent signalés à un jeune âge. Financé par le programme Actions Marie Skłodowska-Curie, le projet LIVER-X se penchera sur la contribution d’un environnement complexe à la santé hépatique tout au long de l’enfance et au-delà. Le projet adoptera une approche à l’échelle de l’exposome pour étudier les répercussions environnementales grâce à des données de biosurveillance et d’exposition géospatiale recueillies au cours de la grossesse et de l’enfance, qui constituent les étapes les plus vulnérables de la vie. Des techniques d’analyse avancées apporteront la preuve des effets combinés et individuels de multiples facteurs environnementaux sur les marqueurs de lésions hépatiques au cours de l’enfance et de l’adolescence.
Objectif
LIVER-X addresses an important question: how does the environment impact the developmental origins of liver health and disease?
Poor liver health in childhood represents a major public health problem with long-term consequences. Elevated alanine aminotransferase, a marker of liver injury and screening tool for pediatric non-alcoholic fatty liver disease (NAFLD) risk, is increasingly reported at young ages, currently being detected in almost one out of ten children living in Europe and the western world. Although it is well known that an obesogenic diet and genetic predisposition play a role in the development of liver injury and disease, the contribution of the complex environment in which we grow up and live remains unclear. LIVER-X addresses this knowledge gap. The project will leverage the resources of the population-based HELIX and Generation R cohorts and follow an exposome-wide approach to the study of environmental impact by using rich biomonitoring and geospatial exposure data collected at the vulnerable early stages of the lifecourse (pregnancy and childhood). Advanced analysis techniques will be used to provide novel evidence on the individual and combined effects of a wide array of early-life ubiquitous environmental factors, including industrial chemical pollutants, toxic metals, air pollution, and characteristics of the urban natural and built environment, on liver injury markers in childhood and adolescence. The project will also assess whether children’s diet quality and polygenic risk for NAFLD modify vulnerability to environmental impact, and thus aid in identifying susceptible subpopulations and environmental priorities.
LIVER-X fosters research cooperation across disciplines and knowledge transfer. The project aligns with urgent challenges related to environmental pollution, the urban environment and the health of future generations, and thus its results are expected to be of high relevance for researchers, policy makers, and European citizens.
Champ scientifique
- medical and health scienceshealth sciencespublic health
- medical and health sciencesclinical medicineobstetrics
- medical and health scienceshealth sciencesnutrition
- natural sciencesearth and related environmental sciencesenvironmental sciencespollution
- medical and health sciencesclinical medicinehepatology
Mots‑clés
Programme(s)
- HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme
Régime de financement
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European FellowshipsCoordinateur
08036 Barcelona
Espagne