Projektbeschreibung
Die Rolle von Umweltfaktoren bei der Lebergesundheit von Kindern
Eine schlechte Lebergesundheit birgt Probleme mit langfristigen Folgen. In der westlichen Welt werden zunehmend erhöhte Werte der Anzeichen für Lebererkrankungen und die pädiatrische nichtalkoholische Fettlebererkrankung bei jungen Menschen gemeldet. Über das durch die Marie-Skłodowska-Curie-Maßnahmen finanzierte Projekt LIVER-X sollen die Auswirkungen einer komplexen Umgebung auf die Lebergesundheit im Kindesalter und darüber hinaus erforscht werden. Im Projekt wird mit einem exposomweiten Ansatz die Umweltbelastung anhand von Biomonitoring- und raumbezogenen Expositionsdaten untersucht, die während der Schwangerschaft und Kindheit – also den anfälligsten Lebensphasen – erfasst wurden. Mit fortschrittlichen Analyseverfahren werden Nachweise zu den kombinierten und einzelnen Auswirkungen mehrerer Umweltfaktoren auf die Anzeichen für Lebererkrankungen in der Kindheit und Jugend gesammelt.
Ziel
LIVER-X addresses an important question: how does the environment impact the developmental origins of liver health and disease?
Poor liver health in childhood represents a major public health problem with long-term consequences. Elevated alanine aminotransferase, a marker of liver injury and screening tool for pediatric non-alcoholic fatty liver disease (NAFLD) risk, is increasingly reported at young ages, currently being detected in almost one out of ten children living in Europe and the western world. Although it is well known that an obesogenic diet and genetic predisposition play a role in the development of liver injury and disease, the contribution of the complex environment in which we grow up and live remains unclear. LIVER-X addresses this knowledge gap. The project will leverage the resources of the population-based HELIX and Generation R cohorts and follow an exposome-wide approach to the study of environmental impact by using rich biomonitoring and geospatial exposure data collected at the vulnerable early stages of the lifecourse (pregnancy and childhood). Advanced analysis techniques will be used to provide novel evidence on the individual and combined effects of a wide array of early-life ubiquitous environmental factors, including industrial chemical pollutants, toxic metals, air pollution, and characteristics of the urban natural and built environment, on liver injury markers in childhood and adolescence. The project will also assess whether children’s diet quality and polygenic risk for NAFLD modify vulnerability to environmental impact, and thus aid in identifying susceptible subpopulations and environmental priorities.
LIVER-X fosters research cooperation across disciplines and knowledge transfer. The project aligns with urgent challenges related to environmental pollution, the urban environment and the health of future generations, and thus its results are expected to be of high relevance for researchers, policy makers, and European citizens.
Wissenschaftliches Gebiet
- medical and health scienceshealth sciencespublic health
- medical and health sciencesclinical medicineobstetrics
- medical and health scienceshealth sciencesnutrition
- natural sciencesearth and related environmental sciencesenvironmental sciencespollution
- medical and health sciencesclinical medicinehepatology
Schlüsselbegriffe
Programm/Programme
- HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme
Aufforderung zur Vorschlagseinreichung
Andere Projekte für diesen Aufruf anzeigenFinanzierungsplan
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European FellowshipsKoordinator
08036 Barcelona
Spanien