RNA and Cell Biology - from Fundamental Research to Therapies

Project Information

RACE

Grant agreement ID: 101059801

DOI

10.3030/101059801

EC signature date 26 April 2023

Start date 1 September 2023

End date 31 August 2029

Funded under

• Widening participation and spreading excellence

Total cost

€ 13 122 258,75

EU contribution

€ 13 122 258,75

Coordinated by

MIEDZYNARODOWY INSTYTUT BIOLOGII MOLEKULARNEJ I KOMORKOWEJ W WARSZAWIE
Poland

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (1)

List of appointed members of the CAC and recruited TT and IP managers

List of appointed members of the CAC and recruited TT and IP managers (M06)

Websites, patent fillings, videos etc. (1)

Project website and RACE visual identity

Website and RACE visual identity: logo and design charter (M04)

Publications

Peer reviewed articles (36)

Etiology of TP53 mutated complex karyotype acute myeloid leukemia

Author(s): Anna Fedenko, Honorata Czapinska, Alwin Krämer, Friedrich Stölzel, Tilmann Bochtler, Matthias Bochtler
Published in: Leukemia, Issue 40, 2026, ISSN 0887-6924
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41375-025-02835-9

Comprehensive analysis of poly(A) tails in mouse testes and ovaries using Nanopore Direct RNA Sequencing

Author(s): Agnieszka Czarnocka-Cieciura, Michał Brouze, Natalia Gumińska, Seweryn Mroczek, Olga Gewartowska, Paweł S. Krawczyk, Andrzej Dziembowski
Published in: Scientific Data, Issue 12, 2025, ISSN 2052-4463
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41597-024-04226-8

Journal of Biological Chemistry

Author(s): Pankaj Thapa; Rupesh V. Chikale; Natalia A. Szulc; Maria-Teodora Pandrea; Agnieszka Sztyler; Khushboo Jaggi; Marta Niklewicz; Remigiusz A. Serwa; Thorsten Hoppe; Wojciech Pokrzywa
Published in: HSP70 inhibits CHIP E3 ligase activity to maintain germline function in Caenorhabditis elegans., 2024, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology
DOI: 10.1016/J.JBC.2024.107864

Liver sinusoidal endothelial cells constitute a major route for hemoglobin clearance

Author(s): Gabriela Zurawska, Zuzanna Sas, Aneta Jończy, Raghunandan Mahadeva, Patryk Slusarczyk, Marta Chwałek, Daniel Seehofer, Georg Damm, Rafał Mazgaj, Marcin Skórzyński, Maria Kulecka, Izabela Rumieńczyk, Morgane Moulin, Kamil Jastrzębski, Kevin Waldron, Michal Mikula, Anders Etzerodt, Remigiusz Serwa, Marta Miączyńska, Tomasz P Rygiel, Katarzyna Mleczko-Sanecka
Published in: EMBO Reports, Issue 27, 2026, ISSN 1469-3178
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S44319-025-00673-5

A single viral enzyme drives tRNA-dependent hypermodification of DNA at adenine

Author(s): Rebekah M. B. Silva, Anton Slyvka, Yan-Jiun Lee, Chudi Guan, Sean R. Lund, Elisabeth A. Raleigh, Krzysztof Skowronek, Michael S. Kuska, Matthias Bochtler, Peter R. Weigele
Published in: Nature Communications, Issue 17, 2026, ISSN 2041-1723
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41467-026-70671-1

Ammonia Suppresses the Antitumor Activity of Natural Killer Cells and T Cells by Decreasing Mature Perforin

Author(s): Joanna Domagala, Tomasz M. Grzywa, Iwona Baranowska, Magdalena Justyniarska, Ryan Tannir, Agnieszka Graczyk-Jarzynka, Aleksandra Kusowska, Maria Lecka, Marcin Poreba, Klaudyna Fidyt, Katsiaryna Marhelava, Zofia Pilch, Lea K. Picard, Tomasz Wegierski, Kamil Jastrzebski, Marta Krawczyk, Marta Klopotowska, Monika Granica, Doris Urlaub, Szymon Hajduk, Alexandra Neeser, Spencer Moros, Pawel Kozlowski, Malgorzata Bobrowicz, Marta Miaczynska, Leyuan Ma, Carsten Watzl, Magdalena Winiarska
Published in: Cancer Research, Issue 85, 2025, ISSN 0008-5472
Publisher: American Association for Cancer Research (AACR)
DOI: 10.1158/0008-5472.CAN-24-0749

Tmbim5 and Slc8b1 cooperate in tissue-specific mitochondrial calcium regulation in zebrafish

Author(s): Iga Wasilewska, Łukasz Majewski, Dobrochna Adamek-Urbańska, Sofiia Baranykova, Paulina Castañeda-Tamez, Ilka Wittig, Matylda Macias, Aleksandra Szybińska, Axel Methner
Published in: Communications Biology, Issue 9, 2026, ISSN 2399-3642
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S42003-025-09494-7

Activity and structure of human (d)CTP deaminase CDADC1

Author(s): Anton Slyvka, Ishan Rathore, Renbin Yang, Olga Gewartowska, Tapan Kanai, George T. Lountos, Krzysztof Skowronek, Mariusz Czarnocki-Cieciura, Alexander Wlodawer, Matthias Bochtler
Published in: Proceedings of the National Academy of Sciences, Issue 122, 2025, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/PNAS.2424245122

Re-adenylation by TENT5A enhances efficacy of SARS-CoV-2 mRNA vaccines

Author(s): Paweł S. Krawczyk, Michał Mazur, Wiktoria Orzeł, Olga Gewartowska, Sebastian Jeleń, Wiktor Antczak, Karolina Kasztelan, Aleksandra Brouze, Katarzyna Matylla-Kulińska, Natalia Gumińska, Bartosz Tarkowski, Ewelina P. Owczarek, Kamila Affek, Paweł Turowski, Agnieszka Tudek, Małgorzata Sroka, Tomasz Śpiewla, Monika Kusio-Kobiałka, Aleksandra Wesołowska, Dominika Nowis, Jakub Golab, Joanna Kowalska, Jacek Jemielity, Andrzej Dziembowski, Seweryn Mroczek
Published in: Nature, Issue 641, 2025, ISSN 0028-0836
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41586-025-08842-1

Pulmonary delivery of siRNA lipoplexes and lipid nanoparticles using a vibrating mesh nebuliser

Author(s): Michael T. Neary, Lianne M. Mulder, Ciaran O. Leime, Ronan MacLoughlin, Brunella Grassiri, Łukasz Baranowski, Piotr S. Kowalski, Abina M. Crean, Katie B. Ryan
Published in: European Journal of Pharmaceutical Sciences, Issue 216, 2026, ISSN 0928-0987
Publisher: Elsevier BV
DOI: 10.1016/J.EJPS.2025.107386

5′-Triphosphate guanosine RNAs recruit GTP-binding proteins to suppress RIG-I/IFN type I signaling

Author(s): Magdalena Wolczyk, Jacek Szymanski, Ivan Trus, Zara Naz, Nathalie Idlin, Michal Lechowski, Emilia Baranowska, Alicja Bis, Jakub Stanislaw Nowak, Tola Tame, Justyna Jackiewicz, Elzbieta Nowak, Christine Wuebben, Gunther Hartmann, Juri Rappsilber, Gracjan Michlewski
Published in: Molecular Cell, Issue 86, 2026, ISSN 1097-2765
Publisher: Elsevier BV
DOI: 10.1016/J.MOLCEL.2026.04.014

DIS3L, cytoplasmic exosome catalytic subunit, is essential for development but not cell viability in mice.

Author(s): Michał Brouze, Marcin Szpila, Areta Magdalena Czerwińska, Wiktor Antczak, Seweryn Mroczek, Tomasz Kuliński, Anna Maria Hojka-Osińska, Dominik Cysewski, Olga Gewartowska, Dorota Adamska, Jakub Gruchota, Ewa Borsuk, Andrzej Dziembowski
Published in: RNA, 2025, ISSN 1355-8382
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1261/RNA.080350.124

Tissue-specific consequences of tag fusions on protein expression in transgenic mice

Author(s): Gillian C. A. Taylor, Lewis Macdonald, Natalia A. Szulc, Evelina Gudauskaite, Brianda Hernandez Moran, Jennifer M. Brisbane, Molly Donald, Ella Taylor, Dejin Zheng, Bin Gu, Pleasantine Mill, Patricia L. Yeyati, Wojciech Pokrzywa, Claudia Ribeiro de Almeida, Andrew J. Wood
Published in: PLOS Genetics, Issue 21, 2025, ISSN 1553-7404
Publisher: Public Library of Science (PLoS)
DOI: 10.1371/JOURNAL.PGEN.1011830

Terminal nucleotidyltransferase<i>Tent2</i>microRNA A-tailing enzyme regulates excitatory/inhibitory balance in the hippocampus

Author(s): Patrycja Wardaszka-Pianka, Bozena Kuzniewska, Natalia GumiNska, Anna Hojka-Osinska, Monika Puchalska, Jacek Milek, Aleksandra Stawikowska, Pawel Krawczyk, Francois P. Pauzin, Tomasz Wojtowicz, Kasia Radwanska, Clive R. Bramham, Andrzej Dziembowski, Magdalena Dziembowska
Published in: RNA, Issue 31, 2025, ISSN 1355-8382
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1261/RNA.080240.124

Polyadenylation landscape of in vivo long-term potentiation in the rat brain

Author(s): Natalia Gumińska, Francois P. Pauzin, Bożena Kuźniewska, Jacek Miłek, Patrycja Wardaszka-Pianka, Paweł S. Krawczyk, Seweryn Mroczek, Sebastian Jeleń, Patrick U. Pagenhart, Clive R. Bramham, Andrzej Dziembowski, Magdalena Dziembowska
Published in: RNA, Issue 31, 2025, ISSN 1355-8382
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1261/RNA.080485.125

DEGRONOPEDIA: A practical guide to identifying and targeting protein degrons

Author(s): Szulc NA, Pokrzywa W.
Published in: Methods in Enzymology, ISSN 0076-6879
Publisher: Elsevier
DOI: 10.1016/BS.MIE.2025.06.014

The intrinsically disordered AB region: a key modulator of the molecular properties of human RXRγ

Author(s): Katarzyna Sołtys, Krzysztof Skowronek, Dominika Bystranowska, Krzysztof Wycisk, Andrzej Ożyhar
Published in: Cell Communication and Signaling, Issue 23, 2025, ISSN 1478-811X
Publisher: Springer Science and Business Media LLC
DOI: 10.1186/S12964-025-02247-3

Cryo-EM Structure of raiA ncRNA From Clostridium Reveals a New RNA 3D Fold

Author(s): Nagendar Goud Badepally, Tales Rocha de Moura, Elżbieta Purta, Eugene F. Baulin, Janusz M. Bujnicki
Published in: Journal of Molecular Biology, Issue 436, 2025, ISSN 0022-2836
Publisher: Elsevier BV
DOI: 10.1016/J.JMB.2024.168833

DIS3L, cytoplasmic exosome catalytic subunit, is essential for development but not cell viability in mice.

Author(s): Michał Brouze, Marcin Szpila, Areta Magdalena Czerwińska, Wiktor Antczak, Seweryn Mroczek, Tomasz Kuliński, Anna Maria Hojka-Osińska, Dominik Cysewski, Olga Gewartowska, Dorota Adamska, Jakub Gruchota, Ewa Borsuk, Andrzej Dziembowski
Published in: RNA, 2025, ISSN 1355-8382
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1261/RNA.080350.124

DIS3 mutations enhance AID-driven translocations during B-cell activation, promoting transformation to multiple myeloma

Author(s): Tomasz M. Kuliński, Olga Gewartowska, Mélanie Mahé, Karolina Kasztelan, Nina Durys, Anna Stroynowska-Czerwińska, Marta Jedynak-Slyvka, Ewelina P. Owczarek, Debadeep Chaudhury, Marcin Nowotny, Aleksandra Pękowska, Bertrand Séraphin, Andrzej Dziembowski
Published in: Nature Communications, Issue 17, 2026, ISSN 2041-1723
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41467-026-70386-3

BMC Biology

Author(s): Nathalie Idlin; Sivakumar Krishnamoorthy; Magdalena Wolczyk; Mouad Fakhri; Michal Lechowski; Natalia Stec; Jacek Milek; Pratik Kumar Mandal; Jaroslaw Cendrowski; Christos Spanos; Magdalena Dziembowska; Katarzyna Mleczko-Sanecka; Juri Rappsilber; Gracjan Michlewski
Published in: BMC Biology, 2025, ISSN 1741-7007
Publisher: Springer Nature
DOI: 10.1186/S12915-025-02131-Z

The expanding repertoire of ESCRT functions in cell biology and disease

Author(s): James H. Hurley, Alyssa N. Coyne, Marta Miączyńska, Harald Stenmark
Published in: Nature, Issue 642, 2026, ISSN 0028-0836
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41586-025-08950-Y

5′ terminal nucleotide determines the immunogenicity of IVT RNAs

Author(s): Magdalena Wolczyk; Jacek Szymanski; Ivan Trus; Zara Naz; Tola Tame; Agnieszka Bolembach; Nila Roy Choudhury; Karolina Kasztelan; Juri Rappsilber; Andrzej Dziembowski; Gracjan Michlewski
Published in: Nucleic Acids Research, 2024, ISSN 1362-4962
Publisher: Oxford University Press
DOI: 10.1093/NAR/GKAE1252

TENT-5 polyadenylates and regulates male-specific transcripts in <i>Caenorhabditis elegans</i>

Author(s): Zuzanna Mackiewicz, Vladyslava Liudkovska, Andrzej Dziembowski
Published in: G3: Genes, Genomes, Genetics, Issue 16, 2026, ISSN 2160-1836
Publisher: Oxford University Press (OUP)
DOI: 10.1093/G3JOURNAL/JKAG058

Mutation in the mitochondrial chaperone TRAP1 leads to autism with more severe symptoms in males

Author(s): Małgorzata Rydzanicz, Bozena Kuzniewska, Marta Magnowska, Tomasz Wójtowicz, Aleksandra Stawikowska, Anna Hojka, Ewa Borsuk, Ksenia Meyza, Olga Gewartowska, Jakub Gruchota, Jacek Miłek, Patrycja Wardaszka, Izabela Chojnicka, Ludwika Kondrakiewicz, Dorota Dymkowska, Alicja Puścian, Ewelina Knapska, Andrzej Dziembowski, Rafał Płoski, Magdalena Dziembowska
Published in: EMBO Molecular Medicine, Issue 16, 2024, ISSN 1757-4684
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S44321-024-00147-6

MODOMICS: a database of RNA modifications and related information. 2025 update and 20th anniversary

Author(s): Dominik Sordyl, Etienne Boileau, Agata Bernat, Satyabrata Maiti, Sunandan Mukherjee, S Naeim Moafinejad, Masoud Amiri Farsani, Anastasiya Shavina, Andrea Cappannini, Giada Agostini, Silvestro G Conticello, Filip Stefaniak, Christoph Dieterich, Elżbieta Purta, Janusz M Bujnicki
Published in: Nucleic Acids Research, Issue 54, 2026, ISSN 0305-1048
Publisher: Oxford University Press (OUP)
DOI: 10.1093/NAR/GKAF1284

Direct profiling of non-adenosines in poly(A) tails of endogenous and therapeutic mRNAs with Ninetails

Author(s): Natalia Gumińska, Katarzyna Matylla-Kulińska, Paweł S. Krawczyk, Michał Maj, Wiktoria Orzeł, Zuzanna Mackiewicz, Aleksandra Brouze, Seweryn Mroczek, Andrzej Dziembowski
Published in: Nature Communications, Issue 16, 2025, ISSN 2041-1723
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41467-025-57787-6

Degron models: a toolbox for rapid in vivo depletion of essential proteins regulating mRNA metabolism

Author(s): Wiktor Antczak, Marcin Szpila, Katarzyna Sałas, Patrycja Daszczuk, Vanessa Linke, Marta Miączyńska, Andrzej Dziembowski, Olga Gewartowska
Published in: Communications Biology, Issue 9, 2026, ISSN 2399-3642
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S42003-026-09828-Z

Excretory gland cell and NSPC genes in <i>C. elegans</i>: investigating their physiological roles

Author(s): Zuzanna Mackiewicz, Vladyslava Liudkovska, Andrzej Dziembowski
Published in: GENETICS, Issue 231, 2025, ISSN 1943-2631
Publisher: Oxford University Press (OUP)
DOI: 10.1093/GENETICS/IYAF125

Trifluoperazine, an Antipsychotic Drug, Inhibits Viability of Cells Derived From <scp>SEGA</scp> and Cortical Tubers Cultured In Vitro

Author(s): Malgorzata Urbanska, Krzysztof Sadowski, Aleksandra Stawikowska, Ewa Liszewska, Magdalena Mlostek, Wieslawa Grajkowska, Katarzyna Kotulska
Published in: Journal of Neurochemistry, Issue 169, 2026, ISSN 0022-3042
Publisher: Wiley
DOI: 10.1111/JNC.70247

Modeling of mRNA deadenylation rates reveal a complex relationship between mRNA deadenylation and decay

Author(s): Agnieszka Czarnocka-Cieciura, Jarosław Poznański, Matti Turtola, Rafał Tomecki, Paweł S Krawczyk, Seweryn Mroczek, Wiktoria Orzeł, Upasana Saha, Torben Heick Jensen, Andrzej Dziembowski, Agnieszka Tudek
Published in: The EMBO Journal, Issue 43, 2024, ISSN 1460-2075
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S44318-024-00258-3

Structural snapshots of the mechanism of ATP-dependent DNA damage recognition by UvrA

Author(s): Shivlee Nirwal, Mariusz Czarnocki-Cieciura, Weronika Zajko, Krzysztof Skowronek, Roman H. Szczepanowski, Marcin Nowotny
Published in: Nature Communications, Issue 17, 2026, ISSN 2041-1723
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41467-025-67075-Y

Protocol for the preparation of zebrafish whole heart cell suspension for single-cell analyses

Author(s): Karim Abu Nahia; Cecilia Lanny Winata
Published in: STAR Protocols, 2025, ISSN 2666-1667
Publisher: Cell Press
DOI: 10.1016/J.XPRO.2024.103586

From discovery to potential application: engineering a novel M23 peptidase to combat Listeria monocytogenes

Author(s): Magdalena Kaus-Drobek, Marzena Nowacka, Magdalena Gewartowska, Małgorzata Korzeniowska nee Wiweger, Merete Rusås Jensen, Trond Møretrø, Even Heir, Elżbieta Nowak, Izabela Sabała
Published in: Scientific Reports, Issue 15, 2025, ISSN 2045-2322
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41598-025-99141-2

Methods in Enzymology

Author(s): Piechota M, Pokrzywa W.
Published in: Methods in Enzymology, ISSN 0076-6879
Publisher: Elsevier
DOI: 10.1016/BS.MIE.2025.06.026

ARTEM server: an online tool for nucleic acid 3D motif searches, 3D structure superposition and structure-based alignment

Author(s): Dominik Sordyl, Jan Cielesz, Davyd R Bohdan, Eugene F Baulin, Janusz M Bujnicki
Published in: Nucleic Acids Research, Issue 54, 2026, ISSN 0305-1048
Publisher: Oxford University Press (OUP)
DOI: 10.1093/NAR/GKAG428

Intellectual Property Rights

Patent (3)

Derivative of monophosphate dinucleotide, nucleic acid derivative containing it, and a method of obtaining it

Application/Publication number: 44 603623
Date: 2023-09-06
Applicant(s): MIEDZYNARODOWY INSTYTUT BIOLOGII MOLEKULARNEJ I KOMORKOWEJ W WARSZAWIE

EEN EIWIT DAT SPECIFIEK BINDT AAN RNA/DNA-HYBRIDEN

Application/Publication number: 20 2405324
Date: 2024-06-05
Applicant(s): MIEDZYNARODOWY INSTYTUT BIOLOGII MOLEKULARNEJ I KOMORKOWEJ W WARSZAWIE

RNA MOLECULES WITH MODIFIED 3' TERMINAL SEQUENCES AND APPLICATION THEREOF

Application/Publication number: 20 24050093
Date: 2024-11-22
Applicant(s): MIEDZYNARODOWY INSTYTUT BIOLOGII MOLEKULARNEJ I KOMORKOWEJ W WARSZAWIE