Centre of Excellence for the Technologies of Gene and Cell Therapy

Información del proyecto

CTGCT

Identificador del acuerdo de subvención: 101059842

DOI

10.3030/101059842

Fecha de la firma de la CE 25 Abril 2023

Fecha de inicio 1 Septiembre 2023

Fecha de finalización 31 Agosto 2029

Financiado con arreglo a

• Widening participation and spreading excellence

Coste total

€ 14 067 762,50

Aportación de la UE

€ 14 067 762,50

Coordinado por

KEMIJSKI INSTITUT
Slovenia

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Websites, patent fillings, videos etc. (3)

List of CTGCT’s products and services

Detailed list of products and services offered by CTGCT

Plan for dissemination and exploitation including communication activities

Thorough communication and dissemination plan in order to gain the visibility of the CTGCT

Advanced therapies learning box launch

Report on learning material about the advanced therapies, to be used in communication and dissemination activities, published

Publicaciones

Peer reviewed articles (20)

Synthetic Biology for Designing Allostery and Its Potential Biomedical Applications

Autores: Tjaša Plaper, Urška Knez Štibler, Roman Jerala
Publicado en: Journal of Molecular Biology, Edición 437, 2025, ISSN 0022-2836
Editor: Elsevier BV
DOI: 10.1016/J.JMB.2025.169225

Small RNAs, big potential: Engineering microRNA-based synthetic gene circuits

Autores: Archismita Kundu, Roman Jerala
Publicado en: Current Opinion in Chemical Biology, Edición 90, 2026, ISSN 1367-5931
Editor: Elsevier BV
DOI: 10.1016/J.CBPA.2026.102652

Clustering of NLRP3 induced by membrane or protein scaffolds promotes inflammasome assembly

Autores: Elvira Boršić, Taja Železnik Ramuta, Sara Orehek, Mateja Erdani Kreft, Matthias Geyer, Roman Jerala, Iva Hafner-Bratkovič
Publicado en: Nature Communications, Edición 16, 2025, ISSN 2041-1723
Editor: Springer Science and Business Media LLC
DOI: 10.1038/S41467-025-60277-4

CTGCT, Centre of Excellence for the Technologies of Gene and Cell Therapy: Collaborative translation of scientific discoveries into advanced treatments for neurological rare genetic diseases and cancer

Autores: Darja Marolt Presen; Duško Lainšček; Jane Kinghorn; Zsolt Sebestyen; Jurgen Kuball; Leila Amini; Petra Reinke; Anke Fuchs; Roman Jerala; Mojca Benčina
Publicado en: Computational and Structural Biotechnology Journal, Edición 27, 2025, ISSN 2001-0370
Editor: Elsevier
DOI: 10.1016/J.CSBJ.2024.11.051

Cytokine-armed pyroptosis induces antitumor immunity against diverse types of tumors

Autores: Sara Orehek, Taja Železnik Ramuta, Duško Lainšček, Špela Malenšek, Martin Šala, Mojca Benčina, Roman Jerala, Iva Hafner-Bratkovič
Publicado en: Nature Communications, Edición 15, 2024, ISSN 2041-1723
Editor: Springer Science and Business Media LLC
DOI: 10.1038/S41467-024-55083-3

Coupling of Spectrin Repeat Modules for the Assembly of Nanorods and Presentation of Protein Domains

Autores: Klemen Mezgec, Jaka Snoj, Liza Ulčakar, Ajasja Ljubetič, Magda Tušek Žnidarič, Miha Škarabot, Roman Jerala
Publicado en: ACS Nano, Edición 18, 2024, ISSN 1936-0851
Editor: American Chemical Society (ACS)
DOI: 10.1021/ACSNANO.4C07701

The art of designed coiled-coils for the regulation of mammalian cells

Autores: Tjaša Plaper, Erik Rihtar, Taja Železnik Ramuta, Vida Forstnerič, Vid Jazbec, Filip Ivanovski, Mojca Benčina, Roman Jerala
Publicado en: Cell Chemical Biology, Edición 31, 2024, ISSN 2451-9456
Editor: Elsevier BV
DOI: 10.1016/J.CHEMBIOL.2024.06.001

Ultrasound-mediated spatial and temporal control of engineered cells in vivo

Autores: Filip Ivanovski, Maja Meško, Tina Lebar, Marko Rupnik, Duško Lainšček, Miha Gradišek, Roman Jerala, Mojca Benčina
Publicado en: Nature Communications, Edición 15, 2024, ISSN 2041-1723
Editor: Springer Science and Business Media LLC
DOI: 10.1038/S41467-024-51620-2

Ligand-induced assembly of antibody variable fragments for the chemical regulation of biological processes

Autores: Erik Rihtar, Tina Fink, Tina Lebar, Duško Lainšček, Živa Kolenc, Lucija Kadunc Polajnar, Roman Jerala
Publicado en: Cell Chemical Biology, Edición 32(3), 2025, ISSN 2451-9448
Editor: Elsevier Ltd.
DOI: 10.1016/J.CHEMBIOL.2025.01.007

Genotypic, functional, and phenotypic characterization in CTNNB1 neurodevelopmental syndrome

Autores: Nina Žakelj, David Gosar, Špela Miroševič, Stephan J. Sanders, Alicia Ljungdahl, Sayeh Kohani, Shouhe Huang, Lok I Leong, Ying An, Miou-Jing Teo, Fiona Moultrie, Roman Jerala, Duško Lainšček, Vida Forstnerič, Petra Sušjan, Leszek Lisowski, Andrea Perez-Iturralde, Jasna Oražem Mrak, Ho Yin Edwin Chan, Damjan Osredkar
Publicado en: Human Genetics and Genomics Advances, Edición 6, 2025, ISSN 2666-2477
Editor: Elsevier BV
DOI: 10.1016/J.XHGG.2025.100483

Protein Gas Vesicles of <i>Bacillus megaterium</i> as Enhancers of Ultrasound-Induced Transcriptional Regulation

Autores: Vid Jazbec, Nina Varda, Ernest Šprager, Maja Meško, Sara Vidmar, Rok Romih, Marjetka Podobnik, Andreja Kežar, Roman Jerala, Mojca Benčina
Publicado en: ACS Nano, Edición 18, 2024, ISSN 1936-0851
Editor: American Chemical Society (ACS)
DOI: 10.1021/ACSNANO.4C01498

Engineering chimeric PCSK9 for a vaccine against atherosclerosis

Autores: Špela Malenšek; Duško Lainšček; Hana Esih; Sara Orehek; Tina Fink; Anja Golob Urbanc; Aleš Blinc; Roman Jerala
Publicado en: Molecular Therapy. Methods & Clinical Development, Edición 33(3), 2025, ISSN 2329-0501
Editor: Elsevier
DOI: 10.1016/J.OMTM.2025.101535

Repurposing nuclear receptors for ligand-responsive liquid condensate formation and gene regulation

Autores: Erik Rihtar, Tina Fink, Filip Ivanovski, Eva Koplan, Roman Jerala
Publicado en: Nature Communications, Edición 17, 2026, ISSN 2041-1723
Editor: Springer Science and Business Media LLC
DOI: 10.1038/S41467-026-69099-4

RNA trans-splicing to rescue β-catenin: A novel approach for treating CTNNB1-Haploinsufficiency disorder

Autores: Matea Maruna, Petra Sušjan-Leite, Maja Meško, Špela Miroševič, Roman Jerala
Publicado en: Molecular Therapy Nucleic Acids, Edición 36, 2026, ISSN 2162-2531
Editor: Elsevier BV
DOI: 10.1016/J.OMTN.2025.102680

Ultrasound-responsive mammalian cell synthetic biology

Autores: Filip Ivanovski; Vid Jazbec; Nina Varda; Roman Jerala; Mojca Benèina
Publicado en: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, 2025, ISSN 1525-8955
Editor: IEEE
DOI: 10.1109/TUFFC.2025.3570813

Paving the way toward treatment solutions for CTNNB1 syndrome: a patient organization perspective

Autores: Špela Miroševič, Shivang Khandelwal, Emily Amerson, Effie Parks, Mariana Parks, Lauren Cochran, Ana González Hernández, Mirela Ferraro, Leszek Lisowski, Andrea Perez-Iturralde, Wendy Chung, Michele H. Jacob, Nina Žakelj, Duško Lainšček, Vida Forstnerič, P
Publicado en: Therapeutic Advances in Rare Disease, Edición 6, 2025, ISSN 2633-0040
Editor: SAGE
DOI: 10.1177/26330040251318355

MyD88 protein destabilization mitigates NF-κB-dependent protection against macrophage apoptosis

Autores: Duško Lainšček, Simon Horvat, Klemen Dolinar, Filip Ivanovski, Rok Romih, Sergej Pirkmajer, Roman Jerala, Mateja Manček-Keber
Publicado en: Cell Communication and Signaling, Edición 22, 2024, ISSN 0168-3659
Editor: Elsevier BV
DOI: 10.1186/S12964-024-01930-1

Mucoadhesive film for oral delivery of vaccines for protection of the respiratory tract

Autores: Hana Esih, Klemen Mezgec, Martina Billmeier, Špela Malenšek, Mojca Benčina, Blaž Grilc, Sara Vidmar, Mirjana Gašperlin, Marjan Bele, Mihaela Zidarn, Tatjana Lejko Zupanc, Tina Morgan, Ingo Jordan, Volker Sandig, Silke Schrödel, Christian Thirion,
Publicado en: Journal of controlled release, Edición 371, 2024, ISSN 0168-3659
Editor: Elsevier B.V.
DOI: 10.1016/J.JCONREL.2024.05.041

Gene therapy of rare diseases as a milestone in medicine - overview of the field and report on initial experiences in Slovenia

Autores: Urh Grošelj, Marko Kavčič, Ana Drole Torkar, Jan Kafol, Duško Lainšček, Roman Jerala, Matjaž Sever, Samo Zver, Gregor Serša, Maja Čemažar, Primož Strojan, Aleš Grošelj, Mojca Žerjav Tanšek, Špela Miroševič, Simona Ivančan, Tomaž Prelog, David Gosar, Jasna Oražem Mrak, Matej Mlinarič, Sara Bertok, Jernej Kovač, Jana Kodrič, Saba Battelino, Marko Pokorn, Alojz Ihan, Janez Jazbec, Tadej Battelino, Damjan Osredkar
Publicado en: Orphanet Journal of Rare Diseases, Edición 20, 2025, ISSN 1750-1172
Editor: Springer Science and Business Media LLC
DOI: 10.1186/S13023-025-03828-8

Designed allosteric protein logic

Autores: Tjaša Plaper, Estera Merljak, Tina Fink, Tadej Satler, Ajasja Ljubetič, Duško Lainšček, Vid Jazbec, Mojca Benčina, Sintija Stevanoska, Sašo Džeroski, Roman Jerala
Publicado en: Cell Discovery, Edición 10, 2024, ISSN 2056-5968
Editor: Springer Nature
DOI: 10.1038/S41421-023-00635-Y

Derechos de propiedad intelectual

Trademark (3)

CTGCT

Número de solicitud/publicación: 202370936 1
Fecha: 2023-10-30
Solicitante(s): KEMIJSKI INSTITUT

CTGCT

Número de solicitud/publicación: 202370935 1
Fecha: 2023-10-30
Solicitante(s): KEMIJSKI INSTITUT

CTGCT CENTRE FOR THE TECHNOLOGIES OF GENE AND CELL THERAPY

Número de solicitud/publicación: 202370937 1
Fecha: 2023-10-30
Solicitante(s): KEMIJSKI INSTITUT