GIMM-CARE: BOOSTING CLINICAL RESEARCH FOR THE BENEFIT OF SOCIETY

Informations projet

GIMM-CARE

N° de convention de subvention: 101060102

DOI

10.3030/101060102

Date de signature de la CE 26 Avril 2023

Date de début 1 Mai 2023

Date de fin 30 Avril 2029

Financé au titre de

• Widening participation and spreading excellence

Coût total

€ 15 000 000,00

Contribution de l’UE

€ 15 000 000,00

Coordonné par

FUNDACAO GIMM - GULBENKIAN INSTITUTE FOR MOLECULAR MEDICINE
Portugal

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (7)

iMM-CARE Strategic R&I Agenda

The iMM-CARE SRIA will be the result of a quadruple-helix co-creation process with the most important stakeholders in health R&I: citizens and patients, scientists and clinicians, policy-makers and health authorities, and business executives and investors. The SRIA will be available at M1, updated in M36 and M72.

Benchmarking of international best practices in human-centred clinical and translational research; ; Relevant initiatives at regional, national & EU level, synergies to explore and next steps; and White papers, position papers and policy briefs

Visits will be promoted to role model institutions in human-centred clinical and translational research. Benchmarking will be defined and reported in M36 and at the end of the project (M72).Report on implemented relevant initiatives at regional, national & EU level promoting synergies to explore and next steps (M36, M72) White papers, position papers and policy briefs to promote the necessary reforms and R&I investments to improve clinical and translational research in Portugal and EU. Delivery dates: M36, M77

Project Handbook (including the Quality Assurance and Evaluation Plan)

Project Handbook (including the Quality Assurance and Evaluation Plan).

IP Policies for Open Innovation programmes

IP Policies for Open Innovation programmes from WP5.

New governance model, including the Brain Trust and Advisory Boards

Approval and implementation of the new governance model to develop and promote excellence in human-centred clinical and translational research.

Communication, Engagement and Dissemination Plan

Communication, Engagement and Dissemination Plan. First version: M6; updated M36; final version: M72.

Catalogue of Biobank services and collections

Catalogue of Biobank services and collections including Open repository of biological and clinical data of the new longitudinal collections . Updated on 60.

Websites, patent fillings, videos etc. (1)

Science and Art outdoor campaigns

Science and Art outdoor campaigns - 5 campaigns - M26, M38, M50, M62, M71.

Other (11)

Policy Brief on Managing Clinical Research Infrastructures

Policy Brief on Managing Clinical Research Infrastructures in Portugal.

Citizen science node

Citizen science node.

Open Calls

Launch of Open Calls at the iMM-CARE Annual Summits, and promoted widely, to select and fund up to 16 flagship R&I projects that respond to 8 disease-specific missions. $ editions in M27, M39, M51, and M63.

Open Science Digital Hub and Data Portal (beta and final versions)

Open Science Digital Hub - beta version: M15; final version: M72.Open science data portal - beta version: M15; final version: M72.

Training Programs Toolkits

Clinician-Scientist Training Programme Toolkit - Design of the training programme including a basic module on research methods and practices in the clinical settings and more advanced training modules. A digital learning platform and digital content will be created, leveraging existing resources at iMM/FMUL and Aula Vall d’Hebron, including in-person training sessions, on-site visits and experiential learnings at VHIR. Delivery of 2 editions of the Clinician-Scientist Training Programme targeting over 150 health professionals in each edition.Clinical Trials Training Programme Toolkit - Traning program to endow clinical research staff with proper skills, knowledge and tools, including training modules for Clinical Trials Assistants (CTA) and Study Coordinators developed by VHIR.Biobank Training Programme Toolkit - Training will cover key aspects of establishing, maintaining and accessing biobank, including ethical and legislation aspects.

Open Call for Young Fellowship Programme

6 four-year grants for Clinician-Scientists allowing the implementation of a research project aligned with the goals and disease-specific missions of iMM-CARE. An open call will be launched with complementary funding from the National Science Foundation (FCT) already secured.

Digital app to record participants’ clinical history, and dietary & lifestyle habits

Digital app to record participants’ clinical history, and dietary & lifestyle habits as part of Flagship R&I project 1: Highly sensitive and cost-effective test for CRC screening

iMM-CARE Digital Gateway and Ignition Platform

Launch of iMM-CARE Digital Gateway and Launch of iMM-CARE Ignition Platform.

“Chasing the Future Questions’’ Annual Summit

“Chasing the Future Questions’’ Annual Summit: M15, M27, M39, M51, M63, M72.

ELSI Helpdesk

ELSI Helpdesk.

Innovation Challenges

Innovation Challenges:AI and Blockchain Awards - 2 editions in Y3 and Y5Citizen Science Awards - 2 editions in Y5 and Y6Social Sciences and Humanities Awards - 1 edition in Y5

Data Management Plan (1)

Data management plan (initial, updated and final versions)

Data management plan - initial: M6, updated M36, final M72.

Publications

Peer reviewed articles (13)

Regulatory T cells sabotage anti-tumor γδ T cells by creating IL-2–deficient environments

Auteurs: Rafael Blanco-Domínguez, André Miguel Vaz-Pinto, Leandro Barros, Noella Lopes, Beatriz Henriques-Alves, Mariana Carreira, Carlos Labão-Almeida, Julie C. Ribot, Gonçalo J.L. Bernardes, Bruno Silva-Santos, Sofia Mensurado
Publié dans: Journal of Experimental Medicine, Numéro 223, 2026, ISSN 0022-1007
Éditeur: Rockefeller University Press
DOI: 10.1084/JEM.20252133

Scientific Reports

Auteurs: Magalhães, Ana; Cesário, Vanessa; Coutinho, Diogo; Matias, Inês; Domingues, Germana; Pinheiro, Catarina; Serafim, Teresa; Dias, Sérgio
Publié dans: Scientific Reports, 2024, ISSN 2045-2322
Éditeur: Springer Nature (Nature Portfolio)
DOI: 10.1038/S41598-024-59845-3

Scientific Reports

Auteurs: Magalhães, Ana; Cesário, Vanessa; Coutinho, Diogo; Matias, Inês; Domingues, Germana; Pinheiro, Catarina; Serafim, Teresa; Dias, Sérgio
Publié dans: Scientific Reports, 2024, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-024-59845-3

Dual modulation of cytotoxic and checkpoint receptors tunes the efficacy of adoptive Delta One T cell therapy against colorectal cancer

Auteurs: Blanco Dominguez, Rafael; Barros, Leandro; Carreira, Mariana; van der Ploeg, Manon; Condeço, Carolina; Marsères, Gabriel; Ferreira, Cristina; Costa, Carla; Ferreira, Carlos M.; Déchanet-Merville, Julie; de Miranda, Noel F. C. C.; Mensurado, Sofia; Silva-Santos, Bruno
Publié dans: Nature Cancer, 2025, ISSN 2662-1347
Éditeur: Springer Nature (Nature Portfolio)
DOI: 10.1038/S43018-025-00948-9

Unlocking the Role of Metabolic Pathways in Brain Metastatic Disease

Auteurs: Pinto M, Violante S, Cascão R, Faria CC.
Publié dans: Cells, ISSN 2073-4409
Éditeur: Molecular Diversity Preservation International
DOI: 10.3390/CELLS14100707

Nutrition Journal

Auteurs: Charneca, Sofia; Hernando, Ana; Almada-Correia, Inês; Polido Pereira, Joaquim; Vieira, Adriana; Sousa, Joana; Almeida, Ana S.; Motta, Carla Motta; Barreto, Gonçalo; Eklund, Kari K.; Alnso‑Pérez, Ana; Gómez, Rodolfo; Cicc, Francesco; Mauro, Daniele; Pinho, Salomé S.; Fonseca, João Eurico; Costa Reis, Patricia; Guerreiro, Catarina Sousa
Publié dans: Nutrition Journal, 2025, ISSN 1475-2891
Éditeur: Springer Nature (Nature Portfolio)
DOI: 10.1186/S12937-025-01089-6

Immunotherapy in lung cancer brain metastases

Auteurs: Paisana E, Cascão R, Alvoeiro M, Félix F, Martins G, Guerreiro C, Roque R, Cruz R, Pacheco TR, Amado AC, Ferro F, Lopes Machado A, Vilariça AS, Hasmucrai D, Alves P, Faria CC.
Publié dans: npj Precision Oncology, ISSN 2397-768X
Éditeur: Springer Nature
DOI: 10.1038/S41698-025-00901-0

CXCR3 signaling promotes Delta One T cell recruitment and antitumor efficacy in colorectal cancer

Auteurs: Mariana Carreira, Leandro Barros, Rafael M Cruz, Cristina Ferreira, Carla Costa, Carlos M Ferreira, Sofia Mensurado, Bruno Silva-Santos, Rafael Blanco-Domínguez
Publié dans: Journal for ImmunoTherapy of Cancer, Numéro 14, 2026, ISSN 2051-1426
Éditeur: BMJ
DOI: 10.1136/JITC-2025-014668

Sustained Macrophage Reprogramming Is Required for CD8+ T cell–Dependent Long-Term Tumor Eradication

Auteurs: Jardim, Carolina; Bica, Marta; Reis-Sobreiro, Mariana; Teixeira da Mota, Afonso; Lopes, Raquel; Pinto, Miguel Ferreira; Sousa, Neuza; Mensurado, Sofia; Boekhoff, Henning; Scolaro, Tommaso; Reugebrink, Maud; Goncalves-Sousa, Natacha; Kubo, Hiroshi; Gomes, Catarina Monteiro; Brito, Catarina; Argüello, Rafael; Leites, Elvira; Morais, Vanessa; Silva-Santos, Bruno; Barbosa-Morais, Nuno; Serre, Karine
Publié dans: Cancer Immunology Research, 2025, ISSN 2326-6074
Éditeur: AACR
DOI: 10.1158/2326-6066.CIR-24-0797

Immunotherapy in lung cancer brain metastases

Auteurs: Paisana, Eunice; Cascao, Rita; Alvoeiro, Magda; Félix, Francisco; Martins, Guilherme; Guerreiro, Carla; Roque, Rafael; Cruz, Rafael Moiteiro Da; Pacheco, Teresa; Amado, Ana Cristina; Ferro, Filipa; Lopes Machado, Andrea; Vilariça, Ana Sofia; Hasmucrai, Direndra; Alves, Paula; Faria, Claudia
Publié dans: npj Precision Oncology, 2025, ISSN 2397-768X
Éditeur: Springer Nature (Nature Portfolio)
DOI: 10.1038/S41698-025-00901-0

A high-cholesterol diet promotes the intravasation of breast tumor cells through an LDL–LDLR axis

Auteurs: Ana Magalhães, Vanessa Cesário, Diogo Coutinho, Inês Matias, Germana Domingues, Catarina Pinheiro, Teresa Serafim, Sérgio Dias
Publié dans: Scientific Reports, Numéro 14, 2024, ISSN 2045-2322
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/S41598-024-59845-3

Nutrition Journal

Auteurs: Charneca, S., Hernando, A., Almada-Correia, I. et al.
Publié dans: Nutrition Journal, ISSN 1475-2891
Éditeur: Springer Nature
DOI: 10.1186/S12937-025-01089-6

Questions of the future in aging and longevity research at the GIMM Festival

Auteurs: Laura Ward, Claudia C. Faria, Maria M. Mota, João Pedro de Magalhães, Brian K. Kennedy, Miguel Godinho Ferreira, Joana Neves, Pedro Sousa-Victor
Publié dans: Nature Aging, 2026, ISSN 2662-8465
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/S43587-026-01133-Y

Other (4)

Building a Clinical Research Hub in Portugal: The GIMM‑CARE Model

Auteurs: Gulbenkian Institute for Molecular Medicine
Publié dans: Zenodo, 2026
Éditeur: Zenodo
DOI: 10.5281/ZENODO.18352446

Nutrition Journal

Auteurs: Charneca, Sofia; Hernando, Ana; Almada-Correia, Inês; Polido-Pereira, Joaquim; Vieira, Adriana; Sousa, Joana; Almeida, Ana Santos; Motta, Carla; Barreto, Gonçalo; Eklund, Kari K.; Alonso-Pérez, Ana; Gómez, Rodolfo; Cicci, Francesco; Mauro, Daniele; Pinho, Salomé S.; Fonseca, João Eurico; Costa-Reis, Patrícia; Guerreiro, Catarina Sousa
Publié dans: Nutrition Journal, 2025, ISSN 1475-2891
Éditeur: Springer Nature (Nature Portfolio)
DOI: 10.6084/M9.FIGSHARE.28738842.V1

Building a Clinical Research Hub in Portugal: The GIMM‑CARE Model

Auteurs: Lopo de Carvalho, Fausto; Gil Martins Reis, Madalena; Ward, Laura Chloe; Coelho de Faria, Claudia Maria; Moreira Marques Sousa, Cristovão; Veloso Napoleão, Patrícia Alexandra; Cañas, Xavier; Gonzalez-Romero, Francisco
Publié dans: 2026
Éditeur: Zenodo
DOI: 10.5281/ZENODO.18352446

GIMM CARE Strategic Research and Innovation Agenda

Auteurs: Moreira Marques Sousa, C., Ward, L. C., Gil Martins Reis, M., Lopo de Carvalho, F., Coelho de Faria, C. M., Veloso Napoleão, P. A., … Gonzalez-Romero, F.
Éditeur: Zenodo
DOI: 10.5281/ZENODO.20718379

Droits de propriété intellectuelle

Patent (6)

ANTIVIRAL COMPOUND

Numéro de demande/publication: 20 23071954
Date: 2023-08-08
Demandeur(s): INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES

R-LOOP SENSOR

Numéro de demande/publication: 20 24055481
Date: 2024-03-01
Demandeur(s): INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES

TREATMENT OF SPINAL INJURY

Numéro de demande/publication: 20 24058651
Date: 2024-03-28
Demandeur(s): INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES

TRKB-T1 AGONIST FOR THE TREATMENT OF ABSENCE SEIZURE AND/OR COMORBIDITIES

Numéro de demande/publication: 20 23074506
Date: 2023-09-06
Demandeur(s): FUNDACAO GIMM - GULBENKIAN INSTITUTE FOR MOLECULAR MEDICINE

INDUCTION OF CELLULAR LETHALITY IN CANCER

Numéro de demande/publication: 20 24050456
Date: 2024-01-10
Demandeur(s): INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES

COMPOSIÇÃO ANTIMICROBIANA, SEUS MÉTODOS E USOS

Numéro de demande/publication: 11 837322
Date: 2022-12-05
Demandeur(s): INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES