Skip to main content

Bioinspired Oxidation of Hydrocarbons in Confined Spaces

Objective

Selective functionalization of C-H bonds in hydrocarbons is a grand challenge that chemists have tried to address for decades drawing inspiration from enzymatic oxidation reactions, with limited success. The mimicry of metalloenzymes has typically focused on the metal center, overlooking crucial aspects of the enzymatic machinery: secondary coordination effects, molecular recognition, and confinement within the isolated active site of the protein.
Herein, well-established coordination manifolds for Fe- and Mn-based oxidation of C-H bonds will be melded to a synthetic molecular receptor. The novelty of the resulting metallo-cavitand receptors lies in the positioning of the reactive metal center in close proximity to a binding pocket with robust molecular recognition features. The proposed reactions will exploit a structured microenvironment based on carefully designed non-covalent interactions. The designed hosts will bind hydrocarbons and related substrates in a confined space in close proximity to a reactive metal species, promoting site-selective oxidation dictated by the orientation of the substrate within the receptor rather than by the innate reactivity of the different C-H bonds in the structure.
ConfiMet will deliver unprecedented site-selective functionalization reactions in molecules with multiple chemically equivalent C-H bonds, of important impact in the development of sustainable production methods for drugs and other chemical specialties.
This project is a unique opportunity for the researcher to combine existing skills in coordination chemistry and transition metal catalysis with supramolecular chemistry concepts. The stimulating environment provided by the Institute of Computational and Catalysis, a research unit of excellence at Universitat de Girona (Spain), will allow the candidate to develop leadership, communication, and independent thinking skills, enhancing her career prospects in the transition to an independent academic position.

Coordinator

UNIVERSITAT DE GIRONA
Net EU contribution
€ 181 152,96
Address
Placa Sant Domenec 3
17004 Girona
Spain

See on map

Region
Este Cataluña Girona
Activity type
Higher or Secondary Education Establishments
Other funding
No data

Partners (1)

FUNDACIO PRIVADA INSTITUT CATALA D'INVESTIGACIO QUIMICA
Spain
Net EU contribution
No data
Address
Avenida Paissos Catalans 16
43007 Tarragona

See on map

Region
Este Cataluña Tarragona
Activity type
Research Organisations
Other funding
No data