Project description
A nanometric drug delivery system for malignant tumour targeting
Nanometric delivery systems for therapeutic drugs and new tools for the fabrication of multi-functional drug delivery systems enable the shift from passive to active drug carriers for maximum drug efficiency at the target tissue. This shift is critical in cancer therapy, where drugs have a broad spectrum of non-specific activities. The EU-funded HybridNP project aims to develop remotely actuated nanocarriers with the parameters to enable tumour targeting. The nanocarriers composed of thermo-responsive polymer with metal will be designed as asymmetric particles for selectivity uptake by the malignant cells. HybridNP aims to develop the methodology for fabrication, analysis and evaluation of the remote actuation and therapeutic potential of the nanocarriers.
Objective
Current nanometric drug delivery systems have enormous potential to shift clinical practice in diseases that require targeted or site-specific therapy. New tools to fabricating multi-functional drug delivery systems can potentiate drug-carrier activity and offer the necessary shift from inert carriers to active drug carriers that can maximize drug activity in the desired tissue. This is particularly crucial in cancer, where chemotherapy drugs have broad spectrum non-specific activities. Based on our recent findings related to the role of physical properties of nano-carriers e.g. morphology, shape and stiffness in cell specificity, we propose to develop a remotely actuated nanocarrier with optimal parameters to provide tumor targeting. The nanocarriers are composed of thermo-responsive polymer with metal, which can be designed as asymmetric particles with preference of uptake by the more malignant cells. The project includes the development of a novel methodology for fabricating anisotropic metal/polymer hybrid nanoparticles, as well as characterization of their morphology and composition. The remote actuation of the nanocarriers will be measured as well as their theopoetic potential. The high-risk project can lead to an innovative approach in drug delivery with a particulate interest in cancer and other complex diseases.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences chemical sciences polymer sciences
- medical and health sciences clinical medicine oncology
- engineering and technology nanotechnology nano-materials
- medical and health sciences medical biotechnology cells technologies
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC-POC - HORIZON ERC Proof of Concept Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2022-POC1
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
91904 Jerusalem
Israel
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.