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Mycobacteriophages to treat tuberculosis - Passed station or future promise?

Project description

Bacteriophages in the treatment of tuberculosis

Bacteriophages are viruses that infect and kill bacteria. The growing threat of drug resistance brought back interest in this treatment option. Funded by the Marie Skłodowska-Curie Actions programme, the Phage-TB project aims to develop clinical mycobacteriophage (MBP) treatments for tuberculosis (TB) and non-tuberculous mycobacterial (NTM) infections. The DNA of soil-isolated MBPs will be sequenced to select promising MBPs with lytic effects against TB or NTM infections. The phage cocktails will be optimised for inhalation method in the clinical treatment, preserving the phages intact and functional. The selected MBP cocktail against TB will be used in the first clinical study in humans to assess safety, dosing and efficacy.

Coordinator

STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUM
Net EU contribution
€ 238 993,92
Address
Geert Grooteplein 10 Zuid
6525 GA Nijmegen
Netherlands

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Region
Oost-Nederland Gelderland Arnhem/Nijmegen
Activity type
Higher or Secondary Education Establishments
Other funding
No data

Partners (2)

TASK FOUNDATION NPC
South Africa
Net EU contribution
€ 0,00
Address
M2 Karl Bremer Hospital Mike Pienaar Boulevard Belleville
7530 Cape Town

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Activity type
Other
Other funding
No data
STELLENBOSCH UNIVERSITY
South Africa
Net EU contribution
€ 0,00
Address
Victoria Street Administration B Building
7600 Stellenbosch

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Activity type
Higher or Secondary Education Establishments
Other funding
No data