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Viral hijacking of the Hippo pathway - HCMV-encoded viral GPCRs US28 and UL78 differentially modulate the Hippo pathway in cancer.

Project description

How the human cytomegalovirus may affect cancer

Human cytomegalovirus (HCMV) is a herpesvirus that infects 80-100 % of people in Europe. In healthy individuals, there are few symptoms, but recent evidence indicates that there maybe be links between HCMV and cancer and heart disease. To investigate this association, the EU-funded ViHiHippo project is investigating two of the viral proteins, US28 and UL78 that hijack the signalling network of the host cell, specifically the Hippo pathway. Preliminary project findings indicate both proteins hijack the Hippo pathway, but in different ways. The researchers will identify biochemically how each receptor protein operates and use protein knockout to understand exactly how HCMV can influence cancer.

Funding Scheme

MSCA-PF -

Coordinator

STICHTING VU
Net EU contribution
€ 187 624,32
Address
De Boelelaan 1105
1081 HV Amsterdam
Netherlands

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Region
West-Nederland Noord-Holland Groot-Amsterdam
Activity type
Higher or Secondary Education Establishments
Other funding
No data