How the human cytomegalovirus may affect cancer
Human cytomegalovirus (HCMV) is a herpesvirus that infects 80-100 % of people in Europe. In healthy individuals, there are few symptoms, but recent evidence indicates that there maybe be links between HCMV and cancer and heart disease. To investigate this association, the EU-funded ViHiHippo project is investigating two of the viral proteins, US28 and UL78 that hijack the signalling network of the host cell, specifically the Hippo pathway. Preliminary project findings indicate both proteins hijack the Hippo pathway, but in different ways. The researchers will identify biochemically how each receptor protein operates and use protein knockout to understand exactly how HCMV can influence cancer.
Fields of science
- HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme