Forget me not: liver cell interactions in non-alcoholic fatty liver disease
Non-alcoholic fatty liver disease (NAFLD) is associated with excessive accumulation of fat in the liver and may lead to significant pathologies including infections and liver damage. There are no pharmacological treatments for NAFLD, and patients are advised to lose weight. The working hypothesis of the ForgettingNAFLD project funded by the Marie Skłodowska-Curie Actions programme is that the liver possesses memory of inflammation and weight loss is insufficient to restore homeostasis. Researchers aim to investigate the cell interactions in the NAFLD liver and how their perturbation is responsible for this tissue memory. Results may serve as the foundation for resetting cell circuits as a novel treatment in NAFLD patients.
Fields of science
- HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme