From glial cell to neuron: reprogramming via transcription factors
Until a couple decades ago, scientists believed glial cells, including astrocytes, did not serve any function other than structural, acting like a ‘glue’ that holds the neurons together. We now know this heterogeneous population of cells plays important roles in modulating nervous system function, its development and in protecting it or aiding in recovery. Recently, the discovery that endogenous glial cells can be reprogrammed into functional neurons has offered new hope for recovery of neuronal loss after injury or disease. With the support of the Marie Skłodowska-Curie Actions programme, the CELLIDRECUT project will investigate the potential of so-called Onecut transcription factors to reprogramme in vivo astrocytes into functional neurons.
Fields of science
- HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme