Periodic Reporting for period 1 - TheranoXome (Engineered Exosomes for Stimuli-responsive Image-guided Drug delivery for Cancer Theranostic applications.)
Période du rapport: 2023-09-01 au 2025-08-31
1.) Synthesized exosome mimicking cell-membrane nanovesicles (cellsomes) and stimuli-responsive inorganic iron-oxide nanoparticles
2.) Undertook the chemical coupling of cellsomes and iron-oxide nanoparticles to synthesize a novel stimuli-responsive hybrid nanoparticle system
3.) Evaluated the physical, chemical and biological characteristics of the synthesized material and assessed its ability to target cancer cells
4.) Studied its ability to specifically deliver chemotherapeutic drugs to cancer cells and evaluated its potential for magnetic targeting.
Main achievements of the project:
1.) A new stimuli-responsive bio-mimetic nanoparticle system was developed that was less than 200 nm in size
2,) The synthesized material showed a favourable biological response – ability to ´home´ to cancer cells, and at the same time exhibit the ability to response to an external magnetic field stimulus
3.) The developed material when loaded with chemotherapeutic drugs was able to deliver drugs specifically and showed superior cancer cell cytotoxicity as compared to the drug alone
4.) Under the influence of an external magnetic field showed enhanced drug penetration was achieved in a complex 3D tumor environment