Project description
Molecular insight into lung cancer growth
Despite extensive research over the years, there are many aspects of cancer development and progression that remain poorly understood. Investigation of the molecular mechanisms of cancer will help identify prognostic markers as well as therapeutic targets. The Marie Skłodowska-Curie Actions (MSCA) SIRT7-LC project focuses on the nucleophosmin protein, which plays an important role in tumour processes and has been proposed as a prognostic biomarker. It is localised in the nucleus of cells and regulates the activity and stability of tumour suppressors such as p53, as well as enhances the function of the c-myc transcription factor. Researchers will address how modulation of nucleophosmin post-translational modifications may be implicated in lung cancer.
Objective
Lung cancer is the second cause of death due to malignancy and diagnosed patients rarely survive beyond two years. Thus, unveiling the molecular mechanisms underlying lung tumorigenesis is imperative for development of novel therapeutic approaches. The nucleolar protein nucleophosmin (NPM) plays critical roles in cancer progression and is often deregulated in human malignancies. NPM employs distinct mechanisms to control cancer cells growth including regulation of the proto-oncogene c-Myc, a transcription factor often aberrantly activated in lung cancer. Recent studies highlighted the fundamental impact of post-translational modifications in controlling NPM functions. NPM is a deacetylation target of Sirtuin 7 (SIRT7), a member of a class of NAD+ dependent histone/protein deacetylases collectively known as sirtuins. Deacetylation of NPM by SIRT7 is fundamental to control NPM subcellular localization and stimulate NPM-mediated cellular stress responses. SIRT7 also acts as a potent oncogene in different malignancies although through still poorly characterized mechanisms. Thus, SIRT7-LC aims to characterize the impact of the SIRT7-NPM axis on regulation of c-Myc pro-oncogenic activities and its impact on lung cancer cells proliferation in vitro and in vivo, as well as possible aberrant activation of this pathway in human lung cancers and its correlation with prognosis. Thus, SIRT7-LC may lead to identification of novel molecular mechanisms sustaining lung cancer growth that could be targeted for therapeutic interventions. Dr. Alejandro Vaquero, a world-leading expert in the sirtuins field, will supervise this project. His competence in the field together with my expertise in characterization of mouse models of diseases will undoubtedly ensure successful realization of the proposed project, expanding my scientific knowledge, increasing my visibility as scientist and contributing to my development as a fully independent investigator.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences clinical medicine oncology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2021-PF-01
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08916 Badalona
Spain
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