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Genomic and single-cell approaches to establish the molecular basis of stony coral resilience to climate change-related stressors.

Objective

Scleractinian corals are the main builders of the marine reefs that provide a home to roughly a quarter of all marine species. In addition, their photosynthetic symbionts contribute to Earths oxygen, absorb CO2 from the atmosphere, and provide the coral host with most of its metabolic needs. Global changes drastically affecting ocean acidification and temperatures cause the breakdown of this symbiosis. This process is also known as coral bleaching, and it results in a mass decline in coral reefs. Despite the continuous efforts to study this phenomenon, our understanding of the bleaching process is so far limited. It is important to emphasize that different coral species, display distinct responses to stressors, with varying mortality rates following bleaching. Hence, in this action, I will utilize these differences in coral resilience (i) to characterize the cellular and molecular responses to stressors of three corals with different levels of bleaching resilience (Stylophora pistillata, Acropora millepora, and Oculina patagonica); (ii) to identify specific genes that might be key players in coral resilience, and (iii) to design and test pharmacological interventions to modulate coral resilience to thermal and acidification stress. To do so, I will expose corals to thermal and acidification stressors and use single-cell genomics approaches to measure and compare cell type-specific gene expression responses to stressors within and between species. These analyses will highlight candidate molecular pathways and cellular processes responsible for the high resilience of some of these species. Together, this project will provide a high-resolution molecular map of stony coral responses to climate change-related stressors, and it will help me, and others advance towards targeted interventions to ameliorate these effects.

Fields of science (EuroSciVoc)

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Keywords

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Programme(s)

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Topic(s)

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Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships

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Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

(opens in new window) HORIZON-MSCA-2021-PF-01

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Coordinator

FUNDACIO CENTRE DE REGULACIO GENOMICA
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 181 152,96
Address
CARRER DOCTOR AIGUADER 88
08003 Barcelona
Spain

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Region
Este Cataluña Barcelona
Activity type
Research Organisations
Links
Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

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