Project description
Reactive oxygen species affect Leishmania parasite development in the vector insect gut
Vector insects transmit infectious pathogens between humans, or from animals to humans. Phlebotomine sand flies transmit Leishmania parasites, causing leishmaniasis. Besides clonal reproduction, Leishmania engages in sexual cycles, producing hybrid progeny and genetic diversity, which explains changes in tissue tropism, pathology and drug resistance. In vivo generation of hybrids is much more efficient than in vitro, showing that the vector gut environment promotes Leishmania sexual mating. Funded by the Marie Skłodowska-Curie Actions programme, the SF-Leishyb project aims to apply a dual genetic approach to the parasite and the vector to study the role of the reactive oxygen species inside the sand fly gut in the stimulation of Leishmania sexual reproduction.
Fields of science
- medical and health scienceshealth sciencespublic healthepidemiologyepidemics prevention
- medical and health sciencesbasic medicineimmunology
- medical and health sciencesbasic medicinepharmacology and pharmacydrug resistance
- medical and health sciencesbasic medicinepathology
- natural sciencesbiological scienceszoologyentomology
Programme(s)
- HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme
Funding Scheme
HORIZON-AG-UN - HORIZON Unit Grant
Coordinator
75724 Paris Cedex 15
France
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