Impact of Reactive Oxygen Species produced by their sand fly vector on Leishmania sexual hybrid formation

Project description

Reactive oxygen species affect Leishmania parasite development in the vector insect gut

Vector insects transmit infectious pathogens between humans, or from animals to humans. Phlebotomine sand flies transmit Leishmania parasites, causing leishmaniasis. Besides clonal reproduction, Leishmania engages in sexual cycles, producing hybrid progeny and genetic diversity, which explains changes in tissue tropism, pathology and drug resistance. In vivo generation of hybrids is much more efficient than in vitro, showing that the vector gut environment promotes Leishmania sexual mating. Funded by the Marie Skłodowska-Curie Actions programme, the SF-Leishyb project aims to apply a dual genetic approach to the parasite and the vector to study the role of the reactive oxygen species inside the sand fly gut in the stimulation of Leishmania sexual reproduction.

Fields of science

• medical and health sciences › health sciences › public health › epidemiology › epidemics prevention
• medical and health sciences › basic medicine › immunology
• medical and health sciences › basic medicine › pharmacology and pharmacy › drug resistance
• medical and health sciences › basic medicine › pathology
• natural sciences › biological sciences › zoology › entomology

Programme(s)

• HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme

Topic(s)

• HORIZON-MSCA-2021-PF-01-01 - MSCA Postdoctoral Fellowships 2021

Call for proposal

HORIZON-MSCA-2021-PF-01

See other projects for this call

Funding Scheme

HORIZON-AG-UN - HORIZON Unit Grant

Coordinator

INSTITUT PASTEUR

Net EU contribution

€ 211 754,88

Address

Rue Du Docteur Roux 25-28
75724 Paris Cedex 15
France

Region

Ile-de-France › Ile-de-France › Paris

Activity type

Research Organisations

Links

Other funding

No data