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Impact of Reactive Oxygen Species produced by their sand fly vector on Leishmania sexual hybrid formation

Project description

Reactive oxygen species affect Leishmania parasite development in the vector insect gut

Vector insects transmit infectious pathogens between humans, or from animals to humans. Phlebotomine sand flies transmit Leishmania parasites, causing leishmaniasis. Besides clonal reproduction, Leishmania engages in sexual cycles, producing hybrid progeny and genetic diversity, which explains changes in tissue tropism, pathology and drug resistance. In vivo generation of hybrids is much more efficient than in vitro, showing that the vector gut environment promotes Leishmania sexual mating. Funded by the Marie Skłodowska-Curie Actions programme, the SF-Leishyb project aims to apply a dual genetic approach to the parasite and the vector to study the role of the reactive oxygen species inside the sand fly gut in the stimulation of Leishmania sexual reproduction.


Net EU contribution
€ 211 754,88
Rue Du Docteur Roux 25-28
75724 Paris Cedex 15

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Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Other funding
No data