Objective
Protein secretion is a universal trait among organisms, involving multiple steps of quality control, sorting, trafficking, and export; as well as various organelles. Numerous pressing challenges faced by society can be addressed by thoroughly understanding protein secretion. Disease mechanisms can be elucidated, new antimicrobials can be discovered, and high-value proteins can be produced. However, exactly because of its complexity, a full mechanistic understanding of protein secretion is still lacking, impeding full exploitation.
The yeast Saccharomyces cerevisiae is a promising model organism for studying protein secretion and is also a major expression host for industrial heterologous protein production. So far research has only focused on a few lab strains, that are inefficient protein secretors and that do not fully represent this yeast’s natural biodiversity. My preliminary data show that properties considered to be optimal in lab strains often are inferior to those observed in some other, more ‘wild’ yeast. Herein, I propose that natural S. cerevisiae strains can have more efficient protein production and secretion pathways and that the responsible alleles can be identified and exploited creating a robust protein-producing strain. In ProteoYeast, I will combine my skills in omics analyses and systems biology with the host lab’s QTL mapping expertise, unique yeast collection (>1200 strains) and advanced robotic systems to address the existing knowledge gap. This work will be divided into three parts: 1) High-throughput investigation of the natural biodiversity for protein secretion in a high-throughput manner; 2) ‘Round Robin’ QTL approach to identify novel alleles affecting protein secretion; and 3) development of robust strains for high-titer secretion of added-value proteins. Today’s urgent demand for a sustainable bio-based economy, combined with progress in laboratory automation and systems biology make this project timely and fitting to societal needs
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- social sciences sociology industrial relations automation
- natural sciences biological sciences ecology ecosystems
- social sciences economics and business economics bioeconomy
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2021-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
9052 ZWIJNAARDE - GENT
Belgium
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.