Project description
Untangling the protein-protein interaction networks behind plant metabolic adaptation to land
Much as fish evolved into land animals, land plant ancestors evolved from freshwater algae. The water-to-land transition was likely accompanied by the emergence and/or expansion of protein families that supported novel plant metabolic pathways. The pathways themselves have been well studied. However, little is known about the proteins in these pathways and their interactions in complex protein networks. With the support of the Marie Skłodowska-Curie Actions programme, the EPPIMAL project will take a closer look at key enzymes (protein catalysts) in important metabolic pathways of existing land plants. Characterising protein-protein interaction networks will shed light on the evolution of plant metabolic pathways and potentially reveal overlooked proteins.
Objective
Plant colonization of land was a critical evolutionary step for terraformation and the emergence of rich terrestrial ecosystems. Land plant ancestors emerged from freshwater algae and subsequently radiated to yield the astonishing diversity observed nowadays. Extant land plants comprise two major groups, tracheophytes and bryophytes, which represent the vascular and non-vascular stage of their evolution. Recent advances in phylogenomics indicate that the water-to-land transition was accompanied by the emergence and/or expansion of protein families that founded novel plant metabolic pathways. This has been for instance the case for the pathways generating phenylpropanoids, specialized molecules serving as anti-UV and precursors to structural polymers, and the hormones abscisic acid (ABA) and strigolactones (SL) that help plant coordinate stress responses and interaction with microorganisms. While these three plant metabolic pathways are almost fully elucidated, little is known about (i) the organization of involved proteins in interacting networks and (ii) the evolutionary relevance of protein-protein interaction (PPI) networks for the emergence and function of metabolic pathways. EPPIMAL project proposes to answer these questions by exploring the evolution of PPI networks associated with the phenylpropanoid, ABA and SL metabolisms. The project will implement a cutting-edge proximity-dependent labeling (PDL) approach centered on key enzymes to characterize PPI networks in bryophyte and tracheophyte species. The project shall disclose the conservation or expansion of PPI networks in the course of land plant evolution and potentially identify overlooked protein involved in investigated metabolic pathways. PPI data will be complemented with molecular genetics and metabolomics investigations. Altogether, EPPIMAL will bring original information on the evolution of protein networks shaping three iconic land plant metabolic pathways that supported plant adaptation to land.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology phycology
- natural sciences chemical sciences polymer sciences
- natural sciences biological sciences ecology ecosystems
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2021-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
75794 PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.