Project description
Improving detection of marine transmissible cancers
Transmissible cancers are passed between individuals through the transfer of living cancer cells. In nature, there are only three types of transmissible cancer, affecting dogs, Tasmanian devils and marine bivalve molluscs. In the former two mammals, transmission occurs during mating, whereas in molluscs it is possible that cells colonise new hosts through ocean currents or human activity. Funded by the Marie Skłodowska-Curie Actions programme, the Ship Clones project aims to study the biology of transmissible cancer and identify related biomarkers. Since transmissible cancer constitutes a model for understanding cancer metastasis, project results extend beyond marine ecosystems.
Objective
Ship Clones: Characterization and search for biomarker of marine transmissible cancers Clonally transmissible cancers are cell clones that are transmitted between individuals via the transfer of living cancer cells. There are only three known types of naturally occurring clonally transmissible cancers, one of which is a disseminated neoplasia (DN) found in marine bivalves. DN is a leukemia-like cancer characterized by the proliferation of hypertrophied cells. In later stages of the disease, these cells spread throughout all tissues destroying their normal architecture and causing the death of their host organism. A polyphyletic origin of the DN has been detected in the common cockle Cerastoderma edule. DN has appeared on at least six different occasions and the six clones currently known coexist in cockle populations of the European Atlantic coast. In the present proposal high resolution lipidomics and proteomics will be used to screen for clonal biomarkers of DN and help to better understand the biological systems of transmissible cancers. Marine transmissible cancers are interesting biological models to better understand cancer transmissibility and metastasis. Marine clones likely ship using ocean currents to colonize new hosts in different regions. It is likely that they may also be unintentionally introduced by the action of man in disease-free regions. Hence, these cancers represent a potential threat for marine ecosystems, as they negatively impact keystone species (bivalves), that also have important socio-economic value for fisheries. As such, it is paramount to successfully identify, monitor and characterize the prevalence of clonal DN in marine bivalves, before any successful prevention and mitigation actions can be applied.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- agricultural sciences agriculture, forestry, and fisheries fisheries
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- medical and health sciences clinical medicine oncology
- natural sciences biological sciences ecology ecosystems
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2021-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
3810-193 Aveiro
Portugal
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