Objective
In recent years, it has been demonstrated that sleep not only plays a crucial role in cognitive, emotional, and immunological functions but also helps to clear the brain from metabolic waste products via the recently discovered glymphatic system. A physiological marker closely associated with glymphatic clearance is electroencephalographic (EEG) slow-wave activity (SWA, 1-4 Hz). An increase in SWA, driven by high sleep pressure accumulated during the day, is related to a boost of glymphatic clearance. In humans, such temporal neuro-glymphatic coupling has been confirmed by using a combination of sleep EEG and functional magnetic resonance imaging (fMRI), which, however, is challenging to use in sleeping subjects. Recently, a first wearable solution has been developed that allows simultaneous assessment of brain electrophysiology and glymphatic system activity by using a combination of the sleep EEG and non-invasive functional near-infrared spectroscopy (fNIRS). This unique technological solution provides an opportunity for the investigation of neuro-glymphatic coupling in sleep without disturbing natural sleep.
SWA can be boosted by the well-timed presentation of brief auditory stimuli during sleep without otherwise altering natural sleep architecture. This approach is referred to as closed-loop auditory stimulation (CLAS) and has gained a lot of attention from both sleep researchers and the industry. Given that deep sleep is a primary driver of glymphatic clearance, it is of great importance to establish if CLAS can boost glymphatic activity along with SWA enhancement. Evidence for the modulatory effect of CLAS on glymphatic clearance will open new avenues for future implementations of CLAS for prevention and/or therapy of neurodegenerative disorders. For instance, the regulation of glymphatic clearance might be of high clinical relevance in Alzheimers disease, characterised by reduced glymphatic convection causing harmful protein aggregation.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine neurology dementia alzheimer
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences physical sciences optics spectroscopy
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2021-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
6525 GA NIJMEGEN
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.