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Mechanism and significance of de novo gene methylation during reproduction in Marchantia

Project description

Gene methylation study in plant model system

DNA methylation is a fundamental process in gene regulation. However, methylation in plants and animals exhibits distinct patterns, and reprogramming of developmental methylation occurs in different ways. Funded by the Marie Skłodowska-Curie Actions programme, the EPIC project aims to perform a state-of-the-art study of DNA methylation using the plant model system Marchantia polymorpha. The application of high-throughput single-cell methylomics and transcriptomics, combined with innovative molecular techniques, will allow the identification of the developmental processes and epigenetic players involved in the gene methylation reprogramming process. Next, the researchers will investigate the methylation targeting mechanism using genetically modified plant cell lines to confirm the role of gene methylation in transcriptional regulation and development.

Coordinator

AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Net EU contribution
€ 261 380,64
Address
Calle Serrano 117
28006 Madrid
Spain

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Region
Comunidad de Madrid Comunidad de Madrid Madrid
Activity type
Research Organisations
Other funding
No data

Partners (1)

THE SALK INSTITUTE FOR BIOLOGICAL STUDIES
United States
Net EU contribution
€ 0,00
Address
North Torrey Pines Road 10010
92037 La Jolla

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Activity type
Research Organisations
Other funding
No data