Objective
We need to turn our production systems upside down! Instead of using fossil fuels and release carbon dioxide, we need to shift to biobased production with carbon dioxide as the sole carbon source. In nature, this is already done at a scale feeding the worlds human population. The process used in nature is photosynthesis. This environmentally benign production system needs to be expanded to include the synthesis of high-value compounds that are not currently produced in photosynthetic systems or produced in low amounts. When produced in high amounts, these different types of high-value natural products need to be stored without being auto-toxic to the production host. This is where storage in dense biocondensates becomes a key success parameter. Biocondensate formation in plants is a black box, but proposed mechanisms point to phase partitioning induced by proteins with intrinsically disordered domains or by NAtural Deep Eutectic Solvents (NADES). NADES are compounds like sugars, amino acids, organic acids, and choline that when mixed in specific stoichiometric ratios have a lower melting point than the individual components. Certain plants manage to accumulate natural products in very high amounts without autotoxicity or cell homeostasis problems. This is the case in my two proposed experimental systems: Vanilla planifolia, which accumulates vanillin glucoside at 2.2kg/L levels in the plastids of the maturing pods; and Sorghum bicolor that produce the defence compound dhurrin, in amounts reaching 30% of the dry mass in etiolated seedlings. In order to identify the players involved in biocondensate formation, I will combine methods of cellular and organelle isolation with imaging and state-of-the-art analytic chemistry, metabolomics, and transcriptomics. Studying how plants orchestrate the formation of dense biocondensates to store high-value compounds in high amounts would be key to make green bio-production systems feasible.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- engineering and technology environmental engineering energy and fuels
- medical and health sciences basic medicine physiology homeostasis
- natural sciences biological sciences botany
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2021-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
1165 KOBENHAVN
Denmark
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.