Objective
Ageing is the result of accumulated cellular dysfunction and loss of tissue homeostasis, which often leads to the emergence of age-related pathologies such as cancer and cardiovascular disorders. The disruption of tissue homeostasis during ageing is particularly critical in the case of the vascular endothelium. The signaling interface and barrier to external factors is provided by a single layer of endothelial cells in a quiescent state. The maintenance of this quiescent state plays an important role in vascular aging and development of cardiovascular diseases. Previous studies have shown that the FOXO1 is a critical driver of endothelial quiescence, where its loss and overexpression leads to vascular overgrowth and rarefaction, respectively. My preliminary analyses show that gene expression levels of FOXO family varies in aged-tissues and that FOXO1/3/4 mutant mice display significant vascular malformation in the retina.
On the other hand, ageing is associated with an increase of transcriptional noise and accumulation of aberrant RNA, which if not eliminated, may lead to cellular dysfunction. My preliminary data shows that even healthy tissues have significant levels of transcriptional noise, while old individuals present higher levels of such aberrant transcription. However, transcription noise is an unexplored phenomenon impacting cell homeostasis. In addition, my analyses also show that FOXO1 overexpression in cultured human endothelial cells leads to higher levels of transcription noise. Given the accumulating evidence and my preliminary findings, I propose to explore how the dysregulation of FOXO transcription factors increases transcription noise, promoting functional decline of the vascular endothelium through ageing. Understanding the cascade events that drive this transcription aberrancy can have a significant impact on the prevention of cellular function decline and delay a wide range of ageing illnesses.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine ophthalmology
- medical and health sciences clinical medicine oncology
- medical and health sciences basic medicine pathology
- natural sciences biological sciences genetics RNA
- medical and health sciences basic medicine physiology homeostasis
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2021-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
2829 516 Caparica
Portugal
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.