Description du projet
Le rôle de l’exposition chimique dans le développement du diabète gestationnel
La prévalence du diabète sucré gestationnel (DSG) a augmenté de manière spectaculaire au cours des dernières décennies, cette maladie étant désormais diagnostiquée dans 7 à 10 % de toutes les grossesses. Les connaissances sur le grand nombre et les effets des substances chimiques auxquelles les êtres humains sont exposés, en particulier pendant la grossesse, font défaut. Financé par le programme Actions Marie Skłodowska-Curie, le projet MANGO vise à étudier les effets de l’exposition aux substances chimiques pendant la grossesse en mettant l’accent sur le DSG. Les chercheurs vérifieront la présence de substances chimiques dans les échantillons biologiques de 400 femmes enceintes et évalueront la corrélation entre l’exposition aux substances chimiques et les données cliniques. L’objectif est de mettre en œuvre un programme pilote visant à limiter l’exposition aux substances chimiques dangereuses au cours de la grossesse.
Objectif
There is a lack of knowledge on the multitude of chemicals that we are exposed to, and even less is known about the exposure during pregnancy, the most critical window for adverse health effects on both mother and offspring. In turn, the prevalence of Gestational Diabetes Mellitus (GDM) has incredibly increased during the last decades and it is now diagnosed in up to 18% of the pregnancies. In this context, I propose the project “The Chemical Exposome of Pregnant Women with Gestational Diabetes Mellitus (MANGO)” to be co-supervised by Dr. Navas-Acien and Prof. Gary Miller at Columbia Mailman School of Public Health (USA, Third Country for the outgoing phase), and by Prof. Domingo at Universitat Rovira i Virgili (URV, Spain, beneficiary institution and host for the incoming phase). The main scientific goals of MANGO are: (1) to determine the occurrence of non-target chemicals in biological samples of 400 pregnant women; (2) to evaluate the association between the exposure to chemicals and clinical data, exploring the effect modification by sociodemographic, dietary and lifestyle factors; (3) to implement a pilot prevention programme to minimize the exposure to hazardous chemicals during pregnancy. These objectives will be tackled by integrating last advances in high-resolution mass spectrometry (WP1), mathematical models (WP2) and risk assessment and prevention strategies (WP3). MANGO will leverage biological samples of Diabetes and Pregnancy Cohort from Institut d’Investigació Sanitària Pere Virgili/Hospital Universitari Joan XXIII (IISPV/HJXXIII, associated partner) and will return the knowledge to Europe by implementing the first pilot programme to increase the awareness of the exposure to hazardous chemicals. Through this MSCA-PF-GF, my training in environmental epidemiology in USA would capitalize upon my skills on non-target chemical analysis (MSCA cofund in INSULIN Tecniospring), facilitating the start of a new research line and a track-tenure at URV
Champ scientifique
- medical and health scienceshealth sciencespublic healthepidemiology
- medical and health sciencesclinical medicineendocrinologydiabetes
- medical and health sciencesclinical medicineobstetrics
- natural scienceschemical sciencesanalytical chemistrymass spectrometry
- medical and health sciencesbasic medicinetoxicology
Mots‑clés
Programme(s)
- HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme
Régime de financement
HORIZON-TMA-MSCA-PF-GF - HORIZON TMA MSCA Postdoctoral Fellowships - Global FellowshipsCoordinateur
43003 Tarragona
Espagne