Spatially rEsolved Single-cell Approaches in Haematologic MalignanciEs

Project Information

SESAHME

Grant agreement ID: 101068158

DOI

10.3030/101068158

Project closed

EC signature date 1 August 2022

Start date 1 September 2022

End date 31 August 2024

Funded under

• Marie Skłodowska-Curie Actions (MSCA)

Total cost

No data

EU contribution

€ 173 847,36

Coordinated by

UNIVERSITATSKLINIKUM HEIDELBERG
Germany

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (1)

Communication, Dissemination & Outreach Plan

The plan describes the planned measures to maximize the impact of the project including the dissemination and exploitation measures that are planned and the target groups addressed Regarding communication measures and public engagement strategy the aim is to inform and reach out to society and show the activities performed and the use and the benefits the project will have for citizens

Data Management Plan (1)

Data Management Plan

The Data Management Plan describes the data management life cycle for all data sets that will be collected processed or generated by the action It is a document describing what data will be collected processed or generated and following what methodology and standards whether and how this data will be shared andor made open and how it will be curated and preserved

Publications

Peer reviewed articles (5)

Discovery of Tumor Reactive T Cell Receptors in Newly Diagnosed Multiple Myeloma

Author(s): Mirco Friedrich, Niklas Kehl, Simon Steiger, Tim Robin Wagner, Katharina Lindner, Michael Kilian, Julius Michel, Sebastian Uhrig, Raphael Lutz, Nina Prokoph, Alexandra M Poos, Lukas John, Lilli Sophie Sester, Niels Weinhold, Stefan Fröhling, Edward W Green, Lukas Bunse, Paola Neri, Nizar Jacques Bahlis, Karsten Rippe, Stefan Eichmüller, Carsten Müller-Tidow, Hartmut Goldschmidt, Michael Platten, Marc S Raab
Published in: Blood, Issue 140, 2022, ISSN 0006-4971
Publisher: American Society of Hematology
DOI: 10.1182/blood-2022-169721

Bone Marrow Immune Signatures in Multiple Myeloma Are Linked to Tumor Heterogeneity and Treatment Outcome

Author(s): Simon Steiger, Raphael Lutz, Nina Prokoph, Subarna Palit, Stephan M Tirier, Philipp Reichert, Anja Baumann, Nadine Hefner, Sabrina Schumacher, Dominik Vonficht, Florian Grünschläger, Alexandra M Poos, Lukas John, Laleh Haghverdi, Jan-Philipp Mallm, Elias K Mai, Mirco Friedrich, Katharina Kriegsmann, Mohamed H.S. Awwad, Anna Jauch, Uta Bertsch, Diana Tichy, Carsten Müller-Tidow, Roland Schroers, Hans Salwender, Britta Besemer, Roland Fenk, Katja Weisel, Hartmut Goldschmidt, Stefanie Huhn, Michael Hundemer, Karsten Rippe, Simon Haas, Niels Weinhold, Marc S Raab
Published in: Blood, Issue 140, 2022, ISSN 0006-4971
Publisher: American Society of Hematology
DOI: 10.1182/blood-2022-168685

Resolving the spatial architecture of myeloma and its microenvironment at the single-cell level

Author(s): Lukas John, Alexandra M. Poos, Alexander Brobeil, Carolina Schinke, Stefanie Huhn, Nina Prokoph, Raphael Lutz, Barbara Wagner, Maurizio Zangari, Stephan M. Tirier, Jan-Philipp Mallm, Sabrina Schumacher, Dominik Vonficht, Llorenç Solé-Boldo, Sabine Quick, Simon Steiger, Moritz J. Przybilla, Katharina Bauer, Anja Baumann, Stefan Hemmer, Christoph Rehnitz, Christian Lückerath, Christos Sachpekidis, Gunhild Mechtersheimer, Uwe Haberkorn, Antonia Dimitrakopoulou-Strauss, Philipp Reichert, Bart Barlogie, Carsten Müller-Tidow, Hartmut Goldschmidt, Jens Hillengass, Leo Rasche, Simon F. Haas, Frits van Rhee, Karsten Rippe, Marc S. Raab, Sandra Sauer, Niels Weinhold
Published in: Nature Communications, Issue 14, 2023, ISSN 2041-1723
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s41467-023-40584-4

Multiple myeloma long-term survivors exhibit sustained immune alterations decades after first-line therapy

Author(s): Raphael Lutz, Florian Grünschläger, Malte Simon, Mohamed H. S. Awwad, Marcus Bauer, Schayan Yousefian, Niklas Beumer, Lea Jopp-Saile, Anastasia Sedlmeier, Llorenç Solé-Boldo, Bogdan Avanesyan, Dominik Vonficht, Patrick Stelmach, Georg Steinbuss, Tobias Boch, Simon Steiger, Marc-Andrea Baertsch, Nina Prokoph, Karsten Rippe, Brian G. M. Durie, Claudia Wickenhauser, Andreas Trumpp, Carsten Müller-Tidow, Daniel Hübschmann, Niels Weinhold, Marc S. Raab, Benedikt Brors, Hartmut Goldschmidt, Charles D. Imbusch, Michael Hundemer, Simon Haas
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s41467-024-54543-0

Resolving therapy resistance mechanisms in multiple myeloma by multiomics subclone analysis

Author(s): Alexandra M. Poos, Nina Prokoph, Moritz J. Przybilla, Jan-Philipp Mallm, Simon Steiger, Isabelle Seufert, Lukas John, Stephan M. Tirier, Katharina Bauer, Anja Baumann, Jennifer Rohleder, Umair Munawar, Leo Rasche, K. Martin Kortüm, Nicola Giesen, Philipp Reichert, Stefanie Huhn, Carsten Müller-Tidow, Hartmut Goldschmidt, Oliver Stegle, Marc S. Raab, Karsten Rippe, Niels Weinhold
Published in: Blood, Issue 142, 2023, ISSN 0006-4971
Publisher: American Society of Hematology
DOI: 10.1182/blood.2023019758

Conference proceedings (1)

P-151 Dietary Oleic Acid Influences the Myeloma Immune Microenvironment and Improves Clinical Outcomes

Author(s): Lilli Sester, Juliana de Castilhos, Vadim Borisov, Anna Gambihler, Michael Kilian, Mirco Friedrich, David Vonhören, Gernot Poschet, Jan Frenking, Lukas John, Stefanie Huhn, Philipp Reichert, Elias Karl Mai, Simon Steiger, Nina Prokoph, Carsten Müller-Tidow, Karsten Rippe, Niels Weinhold, Michael Platten, Hartmut Goldschmidt, Christoph Stein-Thöringer, Marc-Steffen Raab
Published in: Clinical Lymphoma Myeloma and Leukemia, Issue 24, 2024, ISSN 2152-2650
Publisher: Elsevier BV
DOI: 10.1016/S2152-2650(24)02054-8