Project description
Bone marrow cues for haematological cancer
Bone marrow is the soft tissue that fills bone cavities and constitutes the primary site of blood cell production. It maintains the phenotype and function of haematopoietic stem cells through a complex interplay of cells and molecules. However, its role in haematological malignancies such as leukaemia and multiple myeloma remains to be fully elucidated. Funded by the Marie Skłodowska-Curie Actions programme, the SESAHME project aims to determine the conditions that allow abnormal cells to accumulate in the bone marrow. To answer this question, researchers will compare the bone marrow of healthy individuals with that of cancer patients. Results will unveil key determinants that will pave the way towards targeted therapies for haematological malignancies.
Objective
A global understanding of therapy response and therapy resistance in haematologic malignancies, including multiple myeloma and acute lymphoblastic leukaemia, in which cancerous cells accumulate in the bone marrow, is still lacking. This is due to the complex nature of the bone marrow. Therefore, the goal of SESAHME is to determine the difference of the bone marrow microenvironment in healthy individuals and patients suffering from multiple myeloma and acute lymphoblastic leukaemia. This will help to understand under which conditions cancerous cells can accumulate and proliferate in the bone marrow which could lead to advanced immunotherapy approaches in the future.
To achieve this, the objectives of SESAHME are to 1) establish a method that allows to determine the immune microenvironment composition in human formalin-fixed paraffin-embedded samples of the bone marrow, which has the potential for high-throughput screening and being cost effective at the same time; and 2) to use this method to characterise a healthy and dysfunctional bone marrow microenvironment that can contribute to multiple myeloma/acute lymphoblastic leukaemia development and progression.
SESAHME will allow the fellow to independently carry out a project which will set the ground to build upon an own, individual research profile to eventually become an independent researcher. Key transferable training will further improve the employability and career prospects of the fellow, as well as increase the fellow’s communication abilities. The host offers a multi-disciplinary environment that is well connected with experts in the field enabling the fellow to develop a new mindset and approaches. The fellow brings international and specialised wet-lab experience that will facilitate knowledge exchange and increase R&I capacity. Finally, SESAHME will increase the global attractiveness of the host via concrete dissemination activities.
Fields of science (EuroSciVoc)
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Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2021-PF-01
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69120 Heidelberg
Germany
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