Project description DEENESFRITPL Hybrid platform to induce death of cancer cells Focusing on the mechanisms underlying cancer cell death is key for producing effective multifunctional materials for oncological applications. Funded by the Marie Skłodowska-Curie Actions programme, the MagGraphZyme project aims to develop a hybrid platform to trigger the intracellular production of reactive oxygen/nitrogen species (ROS/RNS). These species will be used to cause death in cancer cells. To improve ROS/RNS production, the proposed platform will rely on magnetic nanoparticles, N-decorated graphene oxides and a polymer shell (PLGA). Furthermore, certain signalling pathways will be studied to better understand the different cellular pathways involved in the toxicity and final death of the cells. Show the project objective Hide the project objective Objective MagGraphZyme aims at the development of a new hybrid multiplatform capable of triggering the intracellular production of reactive oxygen/nitrogen species (ROS/RNS) for inducing cell death in cancer cells. The proposed hybrid nanosystem, based on the combination of magnetic nanoparticles (MNPs), nitrogen doped graphene oxide (N-GO) and a polymer (PLGA) shell, will improve ROS/RNS production due to the synergistic effects of all components regarding their catalytic activity as peroxidase-mimetic nanozymes. The control of this catalytic activity will be performed by heating the intracellular level via the activation of the constituent MNPs through a remotely applied magnetic field. Thus, a novel approach for intracellular ROS/RNS production and quantification will be implemented. Furthermore, with the aim of understanding the different cells’ pathways involved in the toxicity and the final death of the cells, these hybrid system will be evaluated to investigate pathway-specific ROS/RNS induction of apoptosis and ROS-response mechanisms. Thus, I will study signaling pathways which are known to be influenced by the production of these species. To this end, I propose detailed physical and chemical studies, down to the atomic level, of the MNPs@N-GO-PLGA systems for identifying the relationships between catalytic efficacy and active atomic sites within the structures. These works will be developed by a motivated researcher with a strong background in MNPs, who will enhance and diversify his skills in advanced microscopy techniques and will acquire competences in bio-medicine. This multidisciplinary and innovative proposal will strengthen the collaboration between the hosting institutions, will enable the European hosting institution to reinforce crucial competences in the understanding & production of multifunctional materials and will contribute to improving oncological applications, which is one of the most important scientific challenges with a high social impact. Fields of science natural sciencesbiological sciencescell biologycell signalingengineering and technologynanotechnologynano-materials Programme(s) HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme Topic(s) HORIZON-MSCA-2021-PF-01-01 - MSCA Postdoctoral Fellowships 2021 Call for proposal HORIZON-MSCA-2021-PF-01 See other projects for this call Funding Scheme MSCA-PF - MSCA-PF Coordinator UNIVERSIDAD DE ZARAGOZA Net EU contribution € 261 380,64 Address Calle pedro cerbuna 12 50009 Zaragoza Spain See on map Region Noreste Aragón Zaragoza Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Partners (1) Sort alphabetically Sort by Net EU contribution Expand all Collapse all RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY United States Net EU contribution € 0,00 Address Rutgers plaza 3 08901 New brunswick See on map Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00
