Heart Attack Monitoring Patch (HAMP)

Información del proyecto

HAMP

Identificador del acuerdo de subvención: 101068646

DOI

10.3030/101068646

Proyecto cerrado

Fecha de la firma de la CE 13 Mayo 2022

Fecha de inicio 16 Junio 2022

Fecha de finalización 15 Junio 2024

Financiado con arreglo a

• Marie Skłodowska-Curie Actions (MSCA)

Coste total

Sin datos

Aportación de la UE

€ 148 478,40

Coordinado por

KOC UNIVERSITY
Türkiye

Descripción del proyecto

Dispositivo ponible inalámbrico para el diagnóstico del infarto agudo de miocardio

Los primeros sesenta minutos después de un infarto agudo de miocardio se conocen como la «hora de oro» y son esenciales. Es importante que el paciente reciba asistencia médica adecuada. Disponer de una plataforma de biodetección compacta y fácil de usar, que el paciente o el personal de una ambulancia puedan emplear fuera del entorno hospitalario, es esencial. El proyecto HAMP, financiado con fondos europeos, propone un sistema ponible inalámbrico para el diagnóstico precoz y rápido de un infarto agudo de miocardio fuera del entorno hospitalario. HAMP consiste en un biosensor de NT-proBNP de respuesta rápida basado en electrocinética CA, una matriz de microagujas para el muestreo de fluido intersticial y circuitos de procesamiento de datos y comunicación inalámbrica.

Objetivo

Every year more than 60 million people live with Cardiovascular Disease (CVD), and more than 1.8 million people die as a result of CVD, accounting for 36% of all deaths. Among different types of CVD, heart attack and stroke are the leading cause of death in the EU. The recognized guidelines identify the first one hour after the onset of a heart attack as the golden hour to receive proper medical assistance and prevent death or damage to organs. Hence, there is a vital need for a compact and easy-to-use biosensing platform that can be used outside hospital settings by the patient or the ambulance staff for diagnosis of heart attack within the golden hour. NT-pro-BNP is a desirable biomarker due to its fast release kinetics, higher circulation levels and lower fluctuations. Although significant advances in NT-pro-BNP biosensors generations have been achieved, these face some serious limitations as most of them cannot be used outside hospital settings, requiring physical attendance of patients which leads to losing time (beyond the golden hour) and increased risk of death. In this project, I propose for the first time a wearable and wireless system for early and quick diagnosis of a heart attack outside the hospital setting. The Heart Attack Monitoring Patch (HAMP) that I propose here, is composed of an AC Electrokinetic (ACEK)-based fast-response label-free NT-pro-BNP biosensor, microneedles array for interstitial fluid sampling and data processing, and wireless communication circuits. Although the ACEK phenomenon is a well-established method for the design of rapid biosensors, this is for the first time that the ACEK effect is employed by a wearable biosensing system for high speed (less than a minute) and low LOD (below 1 pg/mL) detection. The HAMP has a compact and conformal structure that is easy to use and can be used when patients feel the first symptoms of a heart attack and results can be conveniently sent to the nearby hospitals within the golden hour.

Palabras clave

• AC Electrokinetic
• wearable
• biosensor
• wireless communication

Programa(s)

• HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) PROGRAMA PRINCIPAL
  

Tema(s)

• HORIZON-MSCA-2021-PF-01-01 - MSCA Postdoctoral Fellowships 2021
  

Régimen de financiación

HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships

Convocatoria de propuestas

HORIZON-MSCA-2021-PF-01

Coordinador

KOC UNIVERSITY

• Aportación neta de la UEn: € 148 478,40
• Dirección: RUMELI FENERI YOLU SARIYER ; 34450 Istanbul ; Turquía
• Región: İstanbul › İstanbul › İstanbul
• Tipo de actividad: Higher or Secondary Education Establishments
• Coste total: Sin datos